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Continuous separation of cells and particles in microfluidic systems
Abstract
The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for preclinical research and clinical diagnostics. This critical review outlines the most recent developments in microfluidic technology for cell and particle separation in continuous flow based systems. (130 references).
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Cited by
Label-free cell separation and sorting in microfluidic systems
Gossett, D. R., Weaver, W. M., Mach, A. J., Hur, S. C., Tse, H. T. K., Lee, W., Amini, H., & Di Carlo, D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3721-9 · Cited by 930
Surface acoustic wave microfluidics
Ding, X., Li, P., Lin, S.-C. S., Stratton, Z. S., Nama, N., Guo, F., Slotcavage, D., Mao, X., Shi, J., Costanzo, F., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc50361e · Cited by 926
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves
Ding, X., Lin, S.-C. S., Kiraly, B., Yue, H., Li, S., Chiang, I.-K., Shi, J., Benkovic, S. J., & Huang, T. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209288109 · Cited by 912
Acoustic separation of circulating tumor cells
Li, P., Mao, Z., Peng, Z., Zhou, L., Chen, Y., Huang, P.-H., Truica, C. I., Drabick, J. J., El-Deiry, W. S., Dao, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504484112 · Cited by 782
Particle separation and sorting in microfluidic devices: a review
Sajeesh, P., & Sen, A. K. (2014) · Microfluidics and Nanofluidics · doi:10.1007/s10404-013-1291-9 · Cited by 767
Metadata
- Authors
- Lenshof, A., & Laurell, T.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 39
- Issue
- 3
- Pages
- 1203
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2132011262
- Cited by
- 528
- References
- 0
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
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