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Lensfree microscopy on a cellphone
Open accessAbstract
We demonstrate lensfree digital microscopy on a cellphone. This compact and light-weight holographic microscope installed on a cellphone does not utilize any lenses, lasers or other bulky optical components and it may offer a cost-effective tool for telemedicine applications to address various global health challenges. Weighing approximately 38 grams (<1.4 ounces), this lensfree imaging platform can be mechanically attached to the camera unit of a cellphone where the samples are loaded from the side, and are vertically illuminated by a simple light-emitting diode (LED). This incoherent LED light is then scattered from each micro-object to coherently interfere with the background light, creating the lensfree hologram of each object on the detector array of the cellphone. These holographic signatures captured by the cellphone permit reconstruction of microscopic images of the objects through rapid digital processing. We report the performance of this lensfree cellphone microscope by imaging various sized micro-particles, as well as red blood cells, white blood cells, platelets and a waterborne parasite (Giardia lamblia).
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Citations
Cited by
The Smartphone in Medicine: A Review of Current and Potential Use Among Physicians and Students
Ozdalga, E., Ozdalga, A., & Ahuja, N. (2012) · Journal of Medical Internet Research · doi:10.2196/jmir.1994 · Cited by 654
Smartphone-based biosensors: A critical review and perspectives
Roda, A., Michelini, E., Zangheri, M., Di Fusco, M., Calabria, D., & Simoni, P. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.10.019 · Cited by 520
Integrated rapid-diagnostic-test reader platform on a cellphone
Mudanyali, O., Dimitrov, S., Sikora, U., Padmanabhan, S., Navruz, I., & Ozcan, A. (2012) · Lab on a Chip · doi:10.1039/c2lc40235a · Cited by 426
Self-citationCell-Phone-Based Platform for Biomedical Device Development and Education Applications
Smith, Z. J., Chu, K., Espenson, A. R., Rahimzadeh, M., Gryshuk, A., Molinaro, M., Dwyre, D. M., Lane, S., Matthews, D., & Wachsmann-Hogiu, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017150 · Cited by 339
Cellphone-based devices for bioanalytical sciences
Vashist, S. K., Mudanyali, O., Schneider, E. M., Zengerle, R., & Ozcan, A. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7473-1 · Cited by 305
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Metadata
- Authors
- Tseng, D., Mudanyali, O., Oztoprak, C., Isikman, S. O., Sencan, I., Yaglidere, O., & Ozcan, A.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 10
- Issue
- 14
- Pages
- 1787
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2111765476
- Cited by
- 480
- References
- 0
- FWCI
- 20.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Tseng, D., Mudanyali, O., Oztoprak, C., Isikman, S. O., Sencan, I., Yaglidere, O., & Ozcan, A. (2010). Lensfree microscopy on a cellphone. Lab on a Chip. https://doi.org/10.1039/c003477k
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