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Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry
Abstract
Nanospray desorption electrospray ionization (nano-DESI) mass spectrometry is presented as an ambient pressure liquid extraction-ionization technique for analysis of organic and biological molecules on substrates. Analyte is desorbed into a solvent bridge formed between two capillaries and the analysis surface. One capillary supplies solvent to create and maintain the bridge, while the second capillary transports the dissolved analyte from the bridge to the mass spectrometer. A high voltage applied between the inlet of mass spectrometer and the primary capillary creates a self-aspirating nanospray. This approach enables the separation of desorption and ionization events, thus providing independent control of desorption, ionization, and transport of the analyte. We present analytical capabilities of the method and discuss its potential for imaging applications.
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Cited by
Imaging mass spectrometry in microbiology
Watrous, J. D., & Dorrestein, P. C. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2634 · Cited by 338
Lin, P., Liu, J., Shilling, J. E., Kathmann, S. M., Laskin, J., & Laskin, A. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp02563j · Cited by 306
Self-citationSumner, L. W., Lei, Z., Nikolau, B. J., & Saito, K. (2015) · Natural Product Reports · doi:10.1039/c4np00072b · Cited by 233
Native Mass Spectrometry of Membrane Proteins
Keener, J. E., Zhang, G., & Marty, M. T. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04342 · Cited by 126
Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Bergman, H.-M., & Lanekoff, I. (2017) · The Analyst · doi:10.1039/c7an00885f · Cited by 109
Metadata
- Authors
- Roach, P. J., Laskin, J., & Laskin, A.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 135
- Issue
- 9
- Pages
- 2233
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2093943798
- Cited by
- 479
- References
- 0
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Roach, P. J., Laskin, J., & Laskin, A. (2010). Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry. The Analyst. https://doi.org/10.1039/c0an00312c
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