Native Mass Spectrometry of Membrane Proteins

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How many drug targets are there?

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Ambient Mass Spectrometry

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Membrane proteins bind lipids selectively to modulate their structure and function

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Orbitrap Mass Spectrometry

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Native Mass Spectrometry: What is in the Name?

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Single-Particle Cryo-EM at Crystallographic Resolution

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A Cyclic Ion Mobility-Mass Spectrometry System

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Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry

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Integrative structure and functional anatomy of a nuclear pore complex

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Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

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Evolution of Orbitrap Mass Spectrometry Instrumentation

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Mass spectrometry of intact membrane protein complexes

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The role of interfacial lipids in stabilizing membrane protein oligomers

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Consequences of Membrane Protein Overexpression in Escherichia coli

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Fully automated liquid extraction‐based surface sampling and ionization using a chip‐based robotic nanoelectrospray platform

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Mini-G proteins: Novel tools for studying GPCRs in their active conformation

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PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

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Rationalizing membrane protein overexpression

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Self‐assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers

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Ion Activation Methods for Peptides and Proteins

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Formation of Supported Bilayers on Silica Substrates

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High-resolution mass spectrometry of small molecules bound to membrane proteins

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Detection and selective dissociation of intact ribosomes in a mass spectrometer

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The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

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An Overview of the Top Ten Detergents Used for Membrane Protein Crystallization

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Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

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Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry

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The role of lipids in mechanosensation

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Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry

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Lipid–protein interactions

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Membrane Protein–Lipid Interactions Probed Using Mass Spectrometry

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Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

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Thermal Dissociation of Multimeric Protein Complexes by Using Nanoelectrospray Mass Spectrometry

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Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry

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High-fidelity mass analysis unveils heterogeneity in intact ribosomal particles

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Small Emitter Tips for Native Mass Spectrometry of Proteins and Protein Complexes from Nonvolatile Buffers That Mimic the Intracellular Environment

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Determining Membrane Protein–Lipid Binding Thermodynamics Using Native Mass Spectrometry

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Lipid, Protein Interactions

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The Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase

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FRET in membrane biophysics: an overview

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Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches

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Charge detection mass spectrometry: weighing heavier things

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Native Mass Spectrometry from Common Buffers with Salts That Mimic the Extracellular Environment

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A subset of annular lipids is linked to the flippase activity of an ABC transporter

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Polymer nanodiscs: Advantages and limitations

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Mass spectrometry guided structural biology

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Ion mobility–mass spectrometry of supramolecular complexes and assemblies

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A New Way To Detect Noncovalently Bonded Complexes of Biomolecules from Liquid Micro-Droplets by Laser Mass Spectrometry

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Probing the Lipid Annular Belt by Gas‐Phase Dissociation of Membrane Proteins in Nanodiscs

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Identifying key membrane protein lipid interactions using mass spectrometry

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Physiological Response to Membrane Protein Overexpression in E. coli

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Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure

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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

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Ion Activation Methods for Peptides and Proteins

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Allostery revealed within lipid binding events to membrane proteins

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Interrogating Membrane Protein Conformational Dynamics within Native Lipid Compositions

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Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry.

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Disassembly of intact multiprotein complexes in the gas phase

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Membrane Protein Solubilization: Recent Advances and Challenges in Solubilization of Serotonin1A Receptors

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Mass spectrometry-enabled structural biology of membrane proteins

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Charge Reduction Stabilizes Intact Membrane Protein Complexes for Mass Spectrometry

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Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology

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Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

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Chemical Additives Enable Native Mass Spectrometry Measurement of Membrane Protein Oligomeric State within Intact Nanodiscs

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Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase

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High-Throughput Mode Liquid Microjunction Surface Sampling Probe

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Multiplexed Charge Detection Mass Spectrometry for High-Throughput Single Ion Analysis of Large Molecules

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Allosteric modulation of protein-protein interactions by individual lipid binding events

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Interfacing Membrane Mimetics with Mass Spectrometry

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Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA

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Fourier Transform-Ion Mobility-Orbitrap Mass Spectrometer: A Next-Generation Instrument for Native Mass Spectrometry

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Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ

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Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale

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Charge state and adduct reduction in electrospray ionization–mass spectrometry using solvent vapor exposure

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Effect of droplet lifetime on where ions are formed in electrospray ionization

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An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

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Specific cardiolipin–SecY interactions are required for proton-motive force stimulation of protein secretion

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Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

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Importance of Direct Interactions with Lipids for the Function of the Mechanosensitive Channel MscL

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Fast Photochemical Oxidation of Proteins Maps the Topology of Intrinsic Membrane Proteins: Light-Harvesting Complex 2 in a Nanodisc

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Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry

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Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

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High-Field Asymmetric Waveform Ion Mobility Spectrometry and Native Mass Spectrometry: Analysis of Intact Protein Assemblies and Protein Complexes

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Stress-Responsive Systems Set Specific Limits to the Overproduction of Membrane Proteins in Bacillus subtilis

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Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Nonionic Detergents

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Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs

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Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance

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How Do Short Chain Nonionic Detergents Destabilize G-Protein-Coupled Receptors?

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Evolution of Structural Biology through the Lens of Mass Spectrometry

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Be Cautious with Crystal Structures of Membrane Proteins or Complexes Prepared in Detergents

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Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry

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Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry

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Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly

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Expanding the mass range for UVPD-based native top-down mass spectrometry

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Native IM-Orbitrap MS: Resolving what was hidden

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Collision Induced Unfolding Classifies Ligands Bound to the Integral Membrane Translocator Protein

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Mass spectrometry beyond the native state

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Surface induced dissociation as a tool to study membrane protein complexes

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A Mass‐Spectrometry‐Based Approach to Distinguish Annular and Specific Lipid Binding to Membrane Proteins

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Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM

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Liquid extraction surface analysis for native mass spectrometry: Protein complexes and ligand binding

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Native LESA TWIMS-MSI: Spatial, Conformational, and Mass Analysis of Proteins and Protein Complexes

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Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins

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Unraveling the Composition and Behavior of Heterogeneous Lipid Nanodiscs by Mass Spectrometry

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Extracting Charge and Mass Information from Highly Congested Mass Spectra Using Fourier-Domain Harmonics

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Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry

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Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

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Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies

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Infrared Laser Activation of Soluble and Membrane Protein Assemblies in the Gas Phase

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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

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Direct Mass Spectrometry Analysis of Protein Complexes and Intact Proteins up to >70 kDa from Tissue

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Toward Automation of Collision-Induced Unfolding Experiments through Online Size Exclusion Chromatography Coupled to Native Mass Spectrometry

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Generation of Charge-Reduced Ions of Membrane Protein Complexes for Native Ion Mobility Mass Spectrometry Studies

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Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry

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Protein-Glass Surface Interactions and Ion Desalting in Electrospray Ionization with Submicron Emitters

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Biophysical EPR Studies Applied to Membrane Proteins

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Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes

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Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes

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A review of traditional and emerging methods to characterize lipid–protein interactions in biological membranes

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Surface-Induced Protein Unfolding in Submicron Electrospray Emitters

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Resolution of Lipoprotein Subclasses by Charge Detection Mass Spectrometry

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Liquid Native MALDI Mass Spectrometry for the Detection of Protein-Protein Complexes

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Ion Mobility-Mass Spectrometry Reveals That α-Hemolysin from Staphylococcus aureus Simultaneously Forms Hexameric and Heptameric Complexes in Detergent Micelle Solutions

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A new azobenzene-based design strategy for detergents in membrane protein research

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Native Mass Spectrometry Imaging and In Situ Top-Down Identification of Intact Proteins Directly from Tissue

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Conclusive Evidence of the Reconstituted Hexasome Proven by Native Mass Spectrometry

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Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS)

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Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone

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Scratching the surface: native mass spectrometry of peripheral membrane protein complexes

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Liberating Native Mass Spectrometry from Dependence on Volatile Salt Buffers by Use of Gábor Transform

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Insights into Cotranslational Membrane Protein Insertion by Combined LILBID-Mass Spectrometry and NMR Spectroscopy

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Mass spectrometry—A versatile tool for characterising the lipid environment of membrane protein assemblies

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Dramatic Improvement in Sensitivity with Pulsed Mode Charge Detection Mass Spectrometry

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Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry

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Mass spectrometry of membrane protein complexes

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Development of native MS capabilities on an extended mass range Q-TOF MS

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Development and Evaluation of a Reverse-Entry Ion Source Orbitrap Mass Spectrometer

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Structural Diversity of Nucleosomes Characterized by Native Mass Spectrometry

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Exploring the Potential of Dendritic Oligoglycerol Detergents for Protein Mass Spectrometry

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Enhanced Multiplexing in Fourier Transform Charge Detection Mass Spectrometry by Decoupling Ion Frequency from Mass to Charge Ratio

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Ion Mobility and Surface Collisions: Submicrometer Capillaries Can Produce Native-like Protein Complexes

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Direct Analysis of Proteins from Solutions with High Salt Concentration Using Laser Electrospray Mass Spectrometry

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Soft Picosecond Infrared Laser Extraction of Highly Charged Proteins and Peptides from Bulk Liquid Water for Mass Spectrometry

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Effects of Individual Ion Energies on Charge Measurements in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS)

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Probing Folded Proteins and Intact Protein Complexes by Desorption Electrospray Ionization Mass Spectrometry

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Native Nanodiscs and the Convergence of Lipidomics, Metabolomics, Interactomics and Proteomics

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Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry

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Nanodiscs and mass spectrometry: Making membranes fly

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Collision-Induced Unfolding Differentiates Functional Variants of the KCNQ1 Voltage Sensor Domain

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Dynamic regulation of lipid–protein interactions

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Chemical crosslinking and mass spectrometry to elucidate the topology of integral membrane proteins

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Detecting Protein–Glycolipid Interactions Using CaR-ESI-MS and Model Membranes: Comparison of Pre-loaded and Passively Loaded Picodiscs

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Protein–Lipid Interactions Stabilize the Oligomeric State of BOR1p from Saccharomyces cerevisiae

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Probing Heteromultivalent Protein–Glycosphingolipid Interactions using Native Mass Spectrometry and Nanodiscs

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Increasing Collisional Activation of Protein Complexes Using Smaller Aperture Source Sampling Cones on a Synapt Q-IM-TOF Instrument with a Stepwave Source

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Lipid Conversion by Cell-Free Synthesized Phospholipid Methyltransferase Opi3 in Defined Nanodisc Membranes Supports an in Trans Mechanism

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In situ analysis of intact proteins by ion mobility mass spectrometry

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Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts

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Atmospheric Pressure Ultraviolet Laser Desorption and Ionization from Liquid Samples for Native Mass Spectrometry

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High-Resolution Native Mass Spectrometry

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Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products

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Native Metabolomics Unveils Suomilide Analogs with Potent Trypsin Inhibitory Activity

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mTMT: An Alternative, Nonisobaric, Tandem Mass Tag Allowing for Precursor-Based Quantification

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