The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Boron-containing inhibitors of synthetases
Abstract
The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic have alleviated many concerns over its use in pharmaceuticals. In addition, the unique physicochemical properties of boronic acids make them an attractive addition to the medicinal chemists toolbox. This tutorial review will discuss these properties and potential benefits for anyone interested in finding novel enzyme inhibitors. An exceptional class of boronic acids, the oxaboroles, will be highlighted and their properties and uses will be discussed in detail. Finally, the current paradigm for the reaction of boronic acids with enzyme nucleophiles will be summarized.
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Cites
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Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
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An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site
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Current Epidemiology and Growing Resistance of Gram-Negative Pathogens
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Trace Elements in Human Nutrition (II)—An Update
Mehri, A. (2020) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_48_19 · Cited by 395
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
António, J. P. M., Russo, R., Carvalho, C. P., Cal, P. M. S. D., & Gois, P. M. P. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00184k · Cited by 303
Discovery research: the scientific challenge of finding new antibiotics
Livermore, D. M., on behalf of the British Society for Antimicrobial Chemotherapy Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development, Blaser, M., Carrs, O., Cassell, G., Fishman, N., Guidos, R., Levy, S., Powers, J., Norrby, R., et al. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr262 · Cited by 284
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Metadata
- Authors
- Baker, S. J., Tomsho, J. W., & Benkovic, S. J.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 40
- Issue
- 8
- Pages
- 4279
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2107529999
- Cited by
- 256
- References
- 35
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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