Mussel-inspired functionalization of carbon nanotubes for hydroxyapatite mineralization
Abstract
Hydroxyapatite (HAp)/carbon nanotubes (CNTs) hybrid composite materials are successfully synthesized via a biomineralization process that employs poly(dopamine) (PDA), a synthetic mimic of mussel adhesive proteins. Creating bio-inorganic composites for regenerative medicine requires appropriate fillers to enhance their mechanical robustness; for example, natural bones are composed mainly of HAp supported by collagen fibers. In this regard, many efforts have been made to harness HAp as a bone substitute through its integration with reinforcing fibrous materials such as CNTs. We found that the formation of a PDA ad-layer on the surface of CNTs changed the hydrophobic CNTs to become bioactive. This enabled efficient interaction between the CNTs and mineral ions (e.g., Ca2+), which facilitated the mineralization of HAp. CNTs functionalized with PDA (CNT-PDA) highly accelerated the formation of HAp when incubated in a simulated body fluid and exhibited a minimal cytotoxic effect on bone osteoblast cells compared to pristine or carboxylated CNTs. Our results show the potential of CNT-PDA as a scaffold material for bone tissue regeneration and implantation.
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Lee et al. coated the CNT surface with 5 nm of PDA, enhancing the dispersion of CNT in aqueous medium.
“Lee et al. coated the CNT surface with 5 nm of PDA, thus enhancing the dispersion of CNT in the aqueous medium [80].”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [80]
Due to improved dispersion, HA was easily mineralized onto the CNTs' surface using SBF solution.
“Due to the improved dispersion, HA was then easily mineralized onto the CNTs’ surface using the SBF solution.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [80]
CNT-PDA-HA hybrid demonstrated lower cytotoxicity (63%) compared with pristine CNT (73%) when tested with osteoblastic MC3T3-E1 cells.
“The CNT-PDA-HA hybrid demonstrated lower cytotoxicity (63%) compared with pristine CNT (73%) when tested with osteoblastic MC3T3-E1 cells [80,81].”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [80]
Cited by
Sorted by citations
Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“The CNT-PDA-HA hybrid demonstrated lower cytotoxicity (63%) compared with pristine CNT (73%) when tested with osteoblastic MC3T3-E1 cells [80,81].”
BackgroundMethodLiu, Z., Qu, S., Zheng, X., Xiong, X., Fu, R., Tang, K., Zhong, Z., & Weng, J. (2014) · Materials Science and Engineering: C · doi:10.1016/j.msec.2014.07.063 · Cited by 67 · see citing works
Wu, M., Wang, T., Wang, Q., & Huang, W. (2019) · Materials Letters · doi:10.1016/j.matlet.2018.10.036 · Cited by 13 · see citing works
- Authors
- Lee, M., Ku, S. H., Ryu, J., & Park, C. B.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Park, Chan Beum
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 20
- Issue
- 40
- Pages
- 8848
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W2142420664
- Cited by
- 93
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 3 · 2012: 8
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- Korea Advanced Institute of Science and Technology
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Keywords
- hydroxyapatite, carbon nanotubes, polydopamine, biomineralization, bioactive materials, bone substitutes, bone regeneration, simulated body fluid, osteoblast cytotoxicity, scaffolds
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