The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery
Abstract
In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metal–organic-framework (MOF)-based nanocomposites that can be potentially used for targeted drug delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4 nanorods with nanocrystals of Cu3(BTC)2 (HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for targeted drug delivery systems. An anti-cancer drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the drug release in physiological saline at 37 °C.
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Cites
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Cited by
Yusuf, V. F., Malek, N. I., & Kailasa, S. K. (2022) · ACS Omega · doi:10.1021/acsomega.2c05310 · Cited by 894
Zhuang, J., Kuo, C.-H., Chou, L.-Y., Liu, D.-Y., Weerapana, E., & Tsung, C.-K. (2014) · ACS Nano · doi:10.1021/nn406590q · Cited by 873
MOF positioning technology and device fabrication
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Composites of metal–organic frameworks: Preparation and application in adsorption
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Applications of magnetic metal–organic framework composites
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Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications
Monteserín, M., Larumbe, S., Martínez, A. V., Burgui, S., & Francisco Martín, L. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19062 · Cited by 27
Metadata
- Authors
- Ke, F., Yuan, Y.-P., Qiu, L.-G., Shen, Y.-H., Xie, A.-J., Zhu, J.-F., Tian, X.-Y., & Zhang, L.-D.
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 21
- Issue
- 11
- Pages
- 3843
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W1979511622
- Cited by
- 403
- References
- 34
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
