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Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery
Abstract
In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metal–organic-framework (MOF)-based nanocomposites that can be potentially used for targeted drug delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4 nanorods with nanocrystals of Cu3(BTC)2 (HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for targeted drug delivery systems. An anti-cancer drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the drug release in physiological saline at 37 °C.
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Metadata
- Authors
- Ke, F., Yuan, Y.-P., Qiu, L.-G., Shen, Y.-H., Xie, A.-J., Zhu, J.-F., Tian, X.-Y., & Zhang, L.-D.
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 21
- Issue
- 11
- Pages
- 3843
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W1979511622
- Cited by
- 403
- References
- 34
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
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