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Phaseguides: a paradigm shift in microfluidic priming and emptying
Abstract
Phaseguide technology gives complete control over filling and emptying of any type of microfluidic structures, independent of the chamber and channel geometry. The technique is based on a step-wise advancement of the liquid-air interface using the meniscus pinning effect. In this paper, the main effects and parameters underlying the phaseguiding principle are discussed and a demonstration is given of its potential for dead angle filling, spatially controlled phaseguide overflow and sequential phaseguide overflow, all accumulating in a passive valving approach. Phaseguides represent a new direction in microfluidic design thinking that will prove a leap forward towards more simple, flexible and reliable microfluidic systems.
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Cited by
Quan, P.-L., Sauzade, M., & Brouzes, E. (2018) · Sensors · doi:10.3390/s18041271 · Cited by 664
Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits
Olanrewaju, A., Beaugrand, M., Yafia, M., & Juncker, D. (2018) · Lab on a Chip · doi:10.1039/c8lc00458g · Cited by 451
Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430
Białkowska, K., Komorowski, P., Bryszewska, M., & Miłowska, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176225 · Cited by 382
Trietsch, S. J., Naumovska, E., Kurek, D., Setyawati, M. C., Vormann, M. K., Wilschut, K. J., Lanz, H. L., Nicolas, A., Ng, C. P., Joore, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00259-3 · Cited by 290
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Metadata
- Authors
- Vulto, P., Podszun, S., Meyer, P., Hermann, C., Manz, A., & Urban, G. A.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 11
- Issue
- 9
- Pages
- 1596
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W1964690307
- Cited by
- 222
- References
- 0
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vulto, P., Podszun, S., Meyer, P., Hermann, C., Manz, A., & Urban, G. A. (2011). Phaseguides: a paradigm shift in microfluidic priming and emptying. Lab on a Chip. https://doi.org/10.1039/c0lc00643b
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
