Natural products targeting telomere maintenance
Abstract
Telomeres are repetitive sequences of DNA found at the ends of chromosomes which determine and restrict the number of replications a cell can undertake. In the majority of cancer cells, telomerase has been found to maintain the length of telomeres, conferring cell immortality and prevention of cell senescence. With the ready availability of assays to detect telomerase activity, numerous telomerase inhibitors have been discovered from a variety of natural sources. This article gives an outline of these natural product-based telomerase inhibitors and their inspiration for analogue design.
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In the breast, ERβ is found in ductal and lobular epithelial cells as well as stromal cells, while ERα is found only in epithelial cells and not stroma.
“In the breast, ERß is found in ductal and lobular epithelial cells as well as stromal cells, while ERα is found only in epithelial cells and not stroma of the breast [177].”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [177]
ERβ appears to be associated with antiproliferative, anticarcinogenic effects, while ERα is thought to promote carcinogenesis and is the form measured clinically in the treatment of breast cancer patients.
“This is important because ERß appears to be associated with antiproliferative, anticarcinogenic effects, while ERα is thought to promote carcinogenesis, and is the form measured clinically in the treatment of breast cancer patients [176,177].”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [177]
Cites
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Telomerase and cancer therapeutics
Harley, C. B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2275 · Cited by 728 · see citing works
Concentration of the Phytoalexin Resveratrol in Wine
Siemann, E. H., & Creasy, L. L. (1992) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1992.43.1.49 · Cited by 719 · see citing works
Telomerase regulation and stem cell behaviour
Flores, I., Benetti, R., & Blasco, M. A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.003 · Cited by 232 · see citing works
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Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review
Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081968 · Cited by 188 · see citing works
- Authors
- Chen, J. L.-Y., Sperry, J., Ip, N. Y., & Brimble, M. A.
- Affiliations
- University of Auckland (NZ)
- Hong Kong University of Science and Technology (HK)
- Corresponding author
- Brimble, Margaret A.
- Venue
- MedChemComm
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 2
- Issue
- 4
- Pages
- 229
- ISSN
- 2040-2503 (ISSN-L)
- 2040-2511
- OpenAlex
- W2142878155
- Cited by
- 41
- References
- 5
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- MedChemComm (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- telomerase inhibitors, natural products, telomere maintenance, telomerase, cancer cell immortality, cellular senescence, structure-activity relationship
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