Telomerase regulation and stem cell behaviour

Shelterin: the protein complex that shapes and safeguards human telomeres

de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056 · see citing works

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784 · see citing works

Telomeres and human disease: ageing, cancer and beyond

Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,690 · see citing works

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · cited 1× · see citing works

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317 · see citing works

Essential role of mouse telomerase in highly proliferative organs

Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · cited 1× · see citing works

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219 · see citing works

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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Direct activation of TERT transcription by c-MYC

Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893 · see citing works

Regulation of telomerase by telomeric proteins.

Smogorzewska, A., & de Lange, T. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.160049 · Cited by 857 · see citing works

Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions

Blackburn, E. H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.11.036 · Cited by 838 · see citing works

Myc activates telomerasePreprint

Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J. (1998) · Genes & Development · doi:10.1101/gad.12.12.1769 · Cited by 653 · see citing works

Telomerase in the human organism

Collins, K., & Mitchell, J. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205083 · Cited by 600 · see citing works

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

García‐Cao, M., O’Sullivan, R. J., Peters, A. H. F. M., Jenuwein, T., & Blasco, M. A. (2003) · Nature Genetics · doi:10.1038/ng1278 · Cited by 557 · see citing works

Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States

Teixeira, M. T., Arneric, M., Sperisen, P., & Lingner, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00334-4 · Cited by 526 · see citing works

Estrogen activates telomerase.

Kyo, S., Takakura, M., Kanaya, T., Zhuo, W., FUJIMOTO, K., Nishio, Y., Orimo, A., & Inoue, M. (1999) · PubMed · Cited by 509 · see citing works

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)

Kyo, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.3.669 · Cited by 494 · see citing works

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

Kang, S. S., Kwon, T., Kwon, D. Y., & Do, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13085 · Cited by 480 · see citing works

Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior

Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448 · see citing works

Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase

Lin, S., & Elledge, S. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00430-6 · Cited by 427 · see citing works

Conditional telomerase induction causes proliferation of hair follicle stem cells

Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425 · see citing works

Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis

Levy, V., Lindon, C., Harfe, B. D., & Morgan, B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.003 · Cited by 419 · see citing works

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

Greenberg, R. A., O’Hagan, R. C., Deng, H., Xiao, Q., Hann, S. R., Adams, R. R., Lichtsteiner, S., Chin, L., Morin, G. B., & DePinho, R. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202669 · Cited by 411 · see citing works

Telosome, a Mammalian Telomere-associated Complex Formed by Multiple Telomeric Proteins

Liu, D., O'Connor, M. S., Qin, J., & Songyang, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409293200 · Cited by 405 · see citing works

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

Horikawa, I., Cable, P. L., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 395 · see citing works

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin

Ghazizadeh, S., & Taichman, L. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1215 · Cited by 347 · see citing works

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

Gonzalo, S., García-Cao, M., Fraga, M. F., Schotta, G., Peters, A. H. F. M., Cotter, S. E., Eguía, R., Dean, D. C., Esteller, M., Jenuwein, T., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1235 · Cited by 343 · see citing works

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

Allsopp, R. C., Morin, G. B., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Blood · doi:10.1182/blood-2002-07-2334 · Cited by 324 · see citing works

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres

Samper, E., Flores, J. M., & Blasco, M. A. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve174 · Cited by 263 · cited 1× · see citing works

Hypermethylation of the human telomerase catalytic subunit (<i>hTERT</i>) gene correlates with telomerase activity

Guilleret, I., Yan, P., Grange, F., Braunschweig, R., Bosman, F. T., & Benhattar, J. (2002) · International Journal of Cancer · doi:10.1002/ijc.10593 · Cited by 260 · see citing works

Subnuclear shuttling of human telomerase induced by transformation and DNA damage

Wong, J. M. Y., Kusdra, L., & Collins, K. (2002) · Nature Cell Biology · doi:10.1038/ncb846 · Cited by 256 · see citing works

Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells

Misiti, S., Nanni, S., Fontemaggi, G., Cong, Y.-S., Wen, J., Hirte, H. W., Piaggio, G., Sacchi, A., Pontecorvi, A., Bacchetti, S., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.3764-3771.2000 · Cited by 254 · see citing works

Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

Kanaya, T., Kyo, S., Hamada, K., Takakura, M., Kitagawa, Y., Harada, H., & Inoue, M. (2000) · PubMed · Cited by 222 · see citing works

Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1.

Güneş, Ç., Lichtsteiner, S., Vasserot, A. P., & Englert, C. (2000) · PubMed · Cited by 217 · see citing works

Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer Cells

Li, H., Zhao, L., Yang, Z., Funder, J. W., & Liu, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33436 · Cited by 213 · see citing works

Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells

Li, H., Zhao, L., Funder, J. W., & Liu, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16729 · Cited by 199 · see citing works

Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells

Allsopp, R., Cheshier, S. H., & Weissman, I. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.917 · Cited by 194 · see citing works

Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA

Li, S., Rosenberg, J. E., Donjacour, A. A., Botchkina, I. L., Hom, Y. K., Cunha, G. R., & Blackburn, E. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0953 · Cited by 192 · see citing works

Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics

Seimiya, H., Muramatsu, Y., Ohishi, T., & Tsuruo, T. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.021 · Cited by 166 · see citing works

Identification of Mad as a repressor of the human telomerase (hTERT) gene

Oh, S., Song, Y., Yim, J., & Kim, T. K. (2000) · Oncogene · doi:10.1038/sj.onc.1203439 · Cited by 161 · see citing works

Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA

Li, S., Crothers, J., Haqq, C. M., & Blackburn, E. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502782200 · Cited by 158 · see citing works

Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells

Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Nature Medicine · doi:10.1038/nm0403-369 · Cited by 155 · see citing works

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

Ferrón, S., Mira, H., Franco, S., Cano-Jaimez, M., Bellmunt, E., Ramírez, C., Fariñas, I., & Blasco, M. A. (2004) · Development · doi:10.1242/dev.01215 · Cited by 152 · see citing works

The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase Gene

Oh, S., Song, Y., Yim, J., & Kim, T. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37473 · Cited by 148 · see citing works

Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging

Blasco, M. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600598 · Cited by 147 · see citing works

Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells

Samper, E., Fernández, P., Eguı́a, R., Martı́n-Rivera, L., Bernad, A., Blasco, M. A., & Aracil, M. (2002) · Blood · doi:10.1182/blood.v99.8.2767 · Cited by 140 · see citing works

E2F-1 represses transcription of the human telomerase reverse transcriptase gene

Crowe, D. L. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2789 · Cited by 135 · see citing works

A Novel Tricomplex of BRCA1, Nmi, and c-Myc Inhibits c-Myc-induced Human Telomerase Reverse Transcriptase Gene (hTERT) Promoter Activity in Breast Cancer

Li, H., Lee, T., & Avraham, H. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112231200 · Cited by 131 · see citing works

Dyskeratosis Congenita - A Disease of Dysfunctional Telomere Maintenance

Mason, P., Wilson, D., & Bessler, M. (2005) · Current Molecular Medicine · doi:10.2174/1566524053586581 · Cited by 129 · cited 1× · see citing works

Hormones and growth factors regulate telomerase activity in ageing and cancer

Bayne, S., & Liu, J. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.05.009 · Cited by 123 · see citing works

Genetic and epigenetic modulation of telomerase activity in development and disease

Liu, L., Lai, S. R., Andrews, L. G., & Tollefsbol, T. O. (2004) · Gene · doi:10.1016/j.gene.2004.06.011 · Cited by 121 · see citing works

A role for the Rb family of proteins in controlling telomere length

García-Cao, M., Gonzalo, S., Dean, D., & Blasco, M. A. (2002) · Nature Genetics · doi:10.1038/ng1011 · Cited by 120 · see citing works

Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Human Telomerase Reverse Transcriptase (hTERT) Expression in Human Cancer and Primary Cells

Konnikova, L., Simeone, M., Kruger, M. M., Kotecki, M., & Cochran, B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0924 · Cited by 119 · see citing works

Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT

Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., & Inoue, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2557 · Cited by 116 · see citing works

Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor

Goueli, B. S., & Janknecht, R. (2003) · Oncogene · doi:10.1038/sj.onc.1206847 · Cited by 115 · see citing works

Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (<i>TERT</i>) in Human and Mouse Cells

Takakura, M., Kyo, S., Inoue, M., Wright, W. E., & Shay, J. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8037-8043.2005 · Cited by 107 · see citing works

Stem cells, aging, and cancer: inevitabilities and outcomes

Bell, D. R., & Zant, G. E. V. (2004) · Oncogene · doi:10.1038/sj.onc.1207949 · Cited by 99 · see citing works

Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription

Endoh, T., Tsuji, N., Asanuma, K., Yagihashi, A., & Watanabe, N. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.12.014 · Cited by 94 · see citing works

Inactivation of hTERT transcription by Tax

Gabet, A., Mortreux, F., Charneau, P., Riou, P., Dodon, M. D., Wu, Y., Jeang, K., & Wattel, E. (2003) · Oncogene · doi:10.1038/sj.onc.1206468 · Cited by 90 · see citing works

Simian Virus 40 Small Tumor Antigen Activates AKT and Telomerase and Induces Anchorage-Independent Growth of Human Epithelial Cells

Yuan, H., Veldman, T., Rundell, K., & Schlegel, R. (2002) · Journal of Virology · doi:10.1128/jvi.76.21.10685-10691.2002 · Cited by 84 · see citing works

Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells

Lopatina, N., Poole, J. C., Saldanha, S. N., Hansen, N. J., Key, J. S., Pita, M. A., Andrews, L. G., & Tollefsbol, T. O. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01033-7 · Cited by 82 · see citing works

The telomerase RNA component Terc is required for the tumour‐promoting effects of Tert overexpression

Cayuela, M. L., Flores, J. M., & Blasco, M. A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400359 · Cited by 76 · see citing works

Telomeres, telomerase, and hematopoietic stem cell biology

Greenwood, M. J., & Lansdorp, P. M. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.07.003 · Cited by 75 · see citing works

Cell cycle regulators in testicular cancer: Loss of p18INK4C marks progression from carcinomain situ to invasive germ cell tumours

Bártková, J., Thullberg, M., Meyts, E. R., Skakkebæk, N. E., & Bartek, J. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000201)85:3 · Cited by 70 · see citing works

Does the reservoir for self-renewal stem from the ends?

Harrington, L. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207948 · Cited by 66 · see citing works

Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells

Won, J., Yim, J., & Kim, T. K. (2002) · The FASEB Journal · doi:10.1096/fj.02-0311fje · Cited by 65 · see citing works

Hematopoietic stem cells in aplastic anemia

Maciejewski, J. P., & Risitano, A. M. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.09.009 · Cited by 41 · see citing works

MDM2 negatively regulates the human telomerase RNA gene promoter

Zhao, J., Bilsland, A. E., Jackson, K., & Keith, W. N. (2005) · BMC Cancer · doi:10.1186/1471-2407-5-6 · Cited by 29 · see citing works

Cellular senescence in cancer and aging.

Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708 · see citing works

Telomere length, stem cells and aging

Blasco, M. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.38 · Cited by 747 · see citing works

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

Marión, R. M., Strati, K., Li, H., Tejera, Á. M., Schoeftner, S., Ortega, S., Serrano, M., & Blasco, M. A. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.12.010 · Cited by 509 · see citing works

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

Beerman, I., Seita, J., Inlay, M. A., Weissman, I. L., & Rossi, D. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.016 · Cited by 445 · see citing works

The roles of senescence and telomere shortening in cardiovascular disease

Fyhrquist, F., Saijonmaa, O. J., & Strandberg, T. E. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.30 · Cited by 368 · see citing works

The longest telomeres: a general signature of adult stem cell compartments

Flores, I., Canela, A., Vera, E., Tejera, A., Cotsarelis, G., & Blasco, M. A. (2008) · Genes &amp; Development · doi:10.1101/gad.451008 · Cited by 352 · see citing works

High-throughput telomere length quantification by FISH and its application to human population studies

Canela, A., Vera, E., Klatt, P., & Blasco, M. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609367104 · Cited by 336 · see citing works

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Wei, J., Wunderlich, M., Fox, C. F., Álvarez, S., Cigudosa, J., Wilhelm, J., Zheng, Y., Cancelas, J., Gu, Y., Jansen, M., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.04.020 · Cited by 354 · see citing works

Telomere biology in healthy aging and disease

Oeseburg, H., de Boer, R. A., van Gilst, W. H., & van der Harst, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0728-1 · Cited by 273 · see citing works

Telomerase: Structure, functions, and activity regulation

Zvereva, M. I., Shcherbakova, D. M., & Донцова, О. А. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910130055 · Cited by 266 · see citing works

The Rate of Increase of Short Telomeres Predicts Longevity in Mammals

Vera, E., de Jesus, B. B., Foronda, M., Flores, J. M., & Blasco, M. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.023 · Cited by 220 · see citing works

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

Andoniadou, C. L., Gaston‐Massuet, C., Reddy, R., Schneider, R. P., Blasco, M. A., Tissier, P. L., Jacques, T. S., Pevny, L., Dattani, M., & Martı́nez-Barberá, J. P. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0957-9 · Cited by 207 · see citing works

A Natural Product Telomerase Activator As Part of a Health Maintenance Program

Harley, C. B., Liu, W., Blasco, M. A., Vera, E., Andrews, W. H., Briggs, L., & Raffaele, J. M. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1085 · Cited by 196 · see citing works

Cancer and ageing: convergent and divergent mechanisms

Serrano, M., & Blasco, M. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2242 · Cited by 182 · see citing works

Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis

Ferrón, S. R., Marqués-Torrejón, M. Á., Mira, H., Flores, I., Taylor, K., Blasco, M. A., & Fariñas, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3836-09.2009 · Cited by 179 · see citing works

Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish

Anchelin, M., Murcia, L., Alcaraz‐Pérez, F., García-Navarro, E. M., & Cayuela, M. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016955 · Cited by 164 · see citing works

Healthy aging and disease: role for telomere biology?

Zhu, H., Belcher, M. D., & van der Harst, P. (2011) · Clinical Science · doi:10.1042/cs20100385 · Cited by 163 · see citing works

Duplications in addition to terminal deletions are present in a proportion of ring chromosomes: clues to the mechanisms of formation

Rossi, E. G., Riegel, M., Messa, J., Gimelli, S., Maraschio, P., Ciccone, R., Stroppi, M., Riva, P., Perrotta, C. S., Mattina, T., et al. (2007) · Journal of Medical Genetics · doi:10.1136/jmg.2007.054007 · Cited by 158 · see citing works

The role of telomeres and telomerase in stem cell aging

Flores, I., & Blasco, M. A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.042 · Cited by 145 · see citing works

Telomere Shortening Reduces Regenerative Capacity after Acute Kidney Injury

Westhoff, J. H., Schildhorn, C., Jacobi, C., Hömme, M., Hartner, A., Braun, H., Kryzer, C., Wang, C., von Zglinicki, T., Kränzlin, B., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009010072 · Cited by 139 · see citing works

Epigenetic regulation of telomeres in human cancer

Vera, E., Canela, A., Fraga, M. F., Esteller, M., & Blasco, M. A. (2008) · Oncogene · doi:10.1038/onc.2008.289 · Cited by 126 · see citing works

Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence†

Sasaki, M., Ikeda, H., Yamaguchi, J., Nakada, S., & Nakanuma, Y. (2008) · Hepatology · doi:10.1002/hep.22348 · Cited by 125 · see citing works

Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice

Cattan, V., Mercier, N., Gardner, J. P., Regnault, V., Labat, C., Mäki-Jouppila, J. H., Nzietchueng, R., Bénétos, A., Kimura, M., Aviv, A., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.007 · Cited by 120 · see citing works

The Effect of Physiological Stimuli on Sarcopenia; Impact of Notch and Wnt Signaling on Impaired Aged Skeletal Muscle Repair

Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 119 · see citing works

Digital Genome-Wide ncRNA Expression, Including SnoRNAs, across 11 Human Tissues Using PolyA-Neutral Amplification

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Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia

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