Cited by 95Catalytic Cross-Coupling ReactionsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods

Palladium-catalyzed hydroacyloxylation of ynamides

Smith, Donna L., Goundry, William R. F., Lam, Hon Wai·2012·Chem. Commun.

Abstract

In the presence of substoichiometric Pd(OAc)(2), carboxylic acids undergo highly regio- and stereoselective additions to ynamides to provide α-acyloxyenamides.

Integrity signals

Registry

Crossref · 10.1039/c1cc13595c

Cites

62 of 62 references verified0 citation errors · 0 not checkable

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  • In current chemical peptide synthesis methods, peptide chain elongation is almost exclusively executed from the C-terminus to the N-terminus (C → N) by employing Nα-protected amino acids as the building blocks.

    “In current chemical peptide synthesis methods, peptide chain elongation is almost exclusively executed from the C-terminus to the N-terminus (C → N) by employing Nα-protected amino acids as the building blocks.11,37”

    From Ynamide Coupling Reagents: Origin and Advances (2024) · cites this paper as [37]

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Authors
Smith, D. L., Goundry, W. R. F., & Lam, H. W.
Affiliations
  • University of Edinburgh (GB)
  • AstraZeneca (United Kingdom) (GB)
Corresponding author
Lam, Hon Wai
Venue
Chem. Commun.
Published
2012
Volume
48
Issue
10
Pages
1505-1507
ISSN
  • 1359-7345 (ISSN-L)
  • 1364-548X
OpenAlex
W1979194753
Cited by
95
References
62
Citations by year
2026: 5 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 13 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 8
FWCI
3.61
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
Engineering and Physical Sciences Research Council (EP/I004769/1)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Catalytic Cross-Coupling Reactions
  • Physical Sciences › Chemistry › Organic Chemistry › Catalytic Alkyne Reactions
  • Physical Sciences › Chemistry › Organic Chemistry › Catalytic C–H Functionalization Methods
Keywords
palladium catalysis, ynamides, carboxylic acid addition, regioselectivity, stereoselectivity, palladium acetate
MeSH terms
Acetates, Amides, Catalysis, Organometallic Compounds, Palladium, Molecular Structure

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