Palladium-catalyzed hydroacyloxylation of ynamides
Abstract
In the presence of substoichiometric Pd(OAc)(2), carboxylic acids undergo highly regio- and stereoselective additions to ynamides to provide α-acyloxyenamides.
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In current chemical peptide synthesis methods, peptide chain elongation is almost exclusively executed from the C-terminus to the N-terminus (C → N) by employing Nα-protected amino acids as the building blocks.
“In current chemical peptide synthesis methods, peptide chain elongation is almost exclusively executed from the C-terminus to the N-terminus (C → N) by employing Nα-protected amino acids as the building blocks.11,37”
From Ynamide Coupling Reagents: Origin and Advances (2024) · cites this paper as [37]
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- Authors
- Smith, D. L., Goundry, W. R. F., & Lam, H. W.
- Affiliations
- University of Edinburgh (GB)
- AstraZeneca (United Kingdom) (GB)
- Corresponding author
- Lam, Hon Wai
- Venue
- Chem. Commun.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 48
- Issue
- 10
- Pages
- 1505-1507
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W1979194753
- Cited by
- 95
- References
- 62
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 13 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Engineering and Physical Sciences Research Council (EP/I004769/1)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Catalytic Cross-Coupling Reactions
- Physical Sciences › Chemistry › Organic Chemistry › Catalytic Alkyne Reactions
- Physical Sciences › Chemistry › Organic Chemistry › Catalytic C–H Functionalization Methods
- Keywords
- palladium catalysis, ynamides, carboxylic acid addition, regioselectivity, stereoselectivity, palladium acetate
- MeSH terms
- Acetates, Amides, Catalysis, Organometallic Compounds, Palladium, Molecular Structure
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