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Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector
Abstract
A novel gene delivery system based on graphene oxide chemically-functionalized with branched polyethylenimine (PEI-GO) is reported. The PEI-GO conjugate was formed by the covalent linking of PEI and GO via an amide bond by widely used EDC chemistry. Thus-prepared PEI-GO exhibits an excellent ability to condense DNA at a low mass ratio with a positive potential of 49 mV. A WST assay reveals that PEI-GO is significantly less cytotoxic than PEI 25 kDa. Finally, the transfection efficiency of PEI-GO was evaluated. It is demonstrated that the luciferase expression of PEI-GO is comparable or even higher than that of the PEI 25 kDa at optimal mass ratio. Moreover, intracellular tracking of Cy3-labelled pGL-3 indicates that PEI-GO could effectively deliver plasmid DNA into cells and be localized in the nucleus. These findings suggest that PEI-GO is a promising candidate for efficient gene delivery.
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Cites
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Dash, P. R., Read, M. L., Barrett, L. B., Wolfert, M. A., & Seymour, L. W. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300843 · Cited by 386
Cited by
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Yang, K., Feng, L., Shi, X., & Liu, Z. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35342c · Cited by 1,634
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Graphene-based materials for tissue engineering
Shin, S. R., Li, Y.-C., Jang, H. L., Khoshakhlagh, P., Akbari, M., Nasajpour, A., Zhang, Y. S., Tamayol, A., & Khademhosseini, A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.007 · Cited by 721
New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Graphene and graphene oxide as nanomaterials for medicine and biology application
Priyadarsini, S., Mohanty, S., Mukherjee, S., Basu, S., & Mishra, M. (2018) · Journal of Nanostructure in Chemistry · doi:10.1007/s40097-018-0265-6 · Cited by 570
Metadata
- Authors
- Chen, B., Liu, M., Zhang, L., Huang, J., Yao, J., & Zhang, Z.
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 21
- Issue
- 21
- Pages
- 7736
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W2023538581
- Cited by
- 338
- References
- 2
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, B., Liu, M., Zhang, L., Huang, J., Yao, J., & Zhang, Z. (2011). Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. Journal of Materials Chemistry. https://doi.org/10.1039/c1jm10341e
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