The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
Open accessAbstract
Traditionally, muscle physiology experiments require multiple tissue samples to obtain morphometric, electrophysiological, and contractility data. Furthermore, these experiments are commonly completed one at a time on cover slips of single cells, isotropic monolayers, or in isolated muscle strips. In all of these cases, variability of the samples hinders quantitative comparisons among experimental groups. Here, we report the design of a "heart on a chip" that exploits muscular thin film technology--biohybrid constructs of an engineered, anisotropic ventricular myocardium on an elastomeric thin film--to measure contractility, combined with a quantification of action potential propagation, and cytoskeletal architecture in multiple tissues in the same experiment. We report techniques for real-time data collection and analysis during pharmacological intervention. The chip is an efficient means of measuring structure-function relationships in constructs that replicate the hierarchical tissue architectures of laminar cardiac muscle.
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Cites
Muscular Thin Films for Building Actuators and Powering Devices
Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765
Self-citationSelf-Organization of Muscle Cell Structure and Function
Grosberg, A., Kuo, P.-L., Guo, C.-L., Geisse, N. A., Bray, M.-A., Adams, W. J., Sheehy, S. P., & Parker, K. K. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001088 · Cited by 116
Self-citationNuclear morphology and deformation in engineered cardiac myocytes and tissues
Bray, M.-A. P., Adams, W. J., Geisse, N. A., Feinberg, A. W., Sheehy, S. P., & Parker, K. K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.028 · Cited by 107
Self-citationControl of myocyte remodeling in vitro with engineered substrates
Geisse, N. A., Sheehy, S. P., & Parker, K. K. (2009) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-009-9182-9 · Cited by 82
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Cited by
Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305
Organs-on-chips at the frontiers of drug discovery
Esch, E. W., Bahinski, A., & Huh, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4539 · Cited by 1,185
Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
Halldorsson, S., Lucumi, E., Gómez-Sjöberg, R., & Fleming, R. M. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.029 · Cited by 1,027
A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Lind, J. U., Busbee, T. A., Valentine, A. D., Pasqualini, F. S., Yuan, H., Yadid, M., Park, S.-J., Kotikian, A., Nesmith, A. P., Campbell, P. H., et al. (2017) · Nature Materials · doi:10.1038/nmat4782 · Cited by 863
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Metadata
- Authors
- Grosberg, A., Alford, P. W., McCain, M. L., & Parker, K. K.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 11
- Issue
- 24
- Pages
- 4165
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2117397508
- Cited by
- 544
- References
- 4
- FWCI
- 31.94
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
