The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Mechanisms of nickel toxicity in microorganisms
Open accessAbstract
Nickel has long been known to be an important human toxicant, including having the ability to form carcinomas, but until recently nickel was believed to be an issue only to microorganisms living in nickel-rich serpentine soils or areas contaminated by industrial pollution. This assumption was overturned by the discovery of a nickel defense system (RcnR/RcnA) found in microorganisms that live in a wide range of environmental niches, suggesting that nickel homeostasis is a general biological concern. To date, the mechanisms of nickel toxicity in microorganisms and higher eukaryotes are poorly understood. In this review, we summarize nickel homeostasis processes used by microorganisms and highlight in vivo and in vitro effects of exposure to elevated concentrations of nickel. On the basis of this evidence we propose four mechanisms of nickel toxicity: (1) nickel replaces the essential metal of metalloproteins, (2) nickel binds to catalytic residues of non-metalloenzymes; (3) nickel binds outside the catalytic site of an enzyme to inhibit allosterically and (4) nickel indirectly causes oxidative stress.
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Cites
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Cited by
Nickel: Human Health and Environmental Toxicology
Genchi, G., Carocci, A., Lauria, G., Sinicropi, M. S., & Catalano, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030679 · Cited by 1,602
Heavy Metal Pollution from Gold Mines: Environmental Effects and Bacterial Strategies for Resistance
Fashola, M., Ngole-Jeme, V., & Babalola, O. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111047 · Cited by 786
Buchman, J. T., Hudson-Smith, N. V., Landy, K. M., & Haynes, C. L. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00053 · Cited by 304
Nowicka, B. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-18419-w · Cited by 293
Ecological Impacts and Potential Hazards of Nickel on Soil Microbes, Plants, and Human Health
Rizwan, M., Usman, K., & Alsafran, M. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142028 · Cited by 113
Metadata
- Authors
- Macomber, L., & Hausinger, R. P.
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2011
- Volume
- 3
- Issue
- 11
- Pages
- 1153
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- OpenAlex
- W2105770217
- Cited by
- 358
- References
- 130
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
