Cited by 152biodegradable polymer synthesis and propertiesAdvanced Polymer Synthesis and CharacterizationHydrogels: synthesis, properties, applications

Bioerodible polyphosphazenes and their medical potential

Allcock, Harry R., Morozowich, Nicole L.·2012·Polym. Chem.

Abstract

An account is presented of the development, evaluation, and current status of an unusual series of polymers optimized specifically for biomedical applications. The polymers are based on the polyphosphazene platform with side groups chosen for their ability to sensitize the polymers to hydrolysis to benign small molecules that can be metabolized or excreted from the body. The largest class of these polymers consists of macromolecules with amino acid ester side groups and these are the main focus of the article. However, a variety of polymers with other side groups also show promise as bioerodible species, and these are mentioned later in the article.

Integrity signals

Registry

Crossref · 10.1039/c1py00468a

Cites

111 of 111 references verified0 citation errors · 0 not checkable

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  • Polyphosphazenes with amino acid side chains are biodegradable and can be employed to aid the regeneration of bone tissue in vivo.

    “Polyphosphazenes with amino acid side chains are biodegradable and can be employed to aid the regeneration of bone tissue in vivo [186 -189].”

    From Ring-Opening Polymerization—An Introductory Review (2013) · cites this paper as [189]

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Authors
Allcock, H. R., & Morozowich, N. L.
Affiliations
Pennsylvania State University (US)
Corresponding author
Allcock, Harry R.
Venue
Polym. Chem.
Published
2012
Volume
3
Issue
3
Pages
578-590
ISSN
  • 1759-9954 (ISSN-L)
  • 1759-9962
OpenAlex
W1975475423
Cited by
152
References
112
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 14 · 2022: 6 · 2021: 6 · 2020: 14 · 2019: 12 · 2018: 18 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 11 · 2012: 5
FWCI
4.58
Type
journal article
Language
en
Open access
closed
Locations
Polymer Chemistry (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
polyphosphazenes, bioerodible polymers, biodegradation, biodegradable polymers, biomedical polymers

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