Bioerodible polyphosphazenes and their medical potential
Abstract
An account is presented of the development, evaluation, and current status of an unusual series of polymers optimized specifically for biomedical applications. The polymers are based on the polyphosphazene platform with side groups chosen for their ability to sensitize the polymers to hydrolysis to benign small molecules that can be metabolized or excreted from the body. The largest class of these polymers consists of macromolecules with amino acid ester side groups and these are the main focus of the article. However, a variety of polymers with other side groups also show promise as bioerodible species, and these are mentioned later in the article.
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Polyphosphazenes with amino acid side chains are biodegradable and can be employed to aid the regeneration of bone tissue in vivo.
“Polyphosphazenes with amino acid side chains are biodegradable and can be employed to aid the regeneration of bone tissue in vivo [186 -189].”
From Ring-Opening Polymerization—An Introductory Review (2013) · cites this paper as [189]
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Huang, Z., Wei, P., Jin, L., Hu, X., Cai, Q., & Yang, X. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02281f · Cited by 13 · see citing works
A strategy for the synthesis of cyclomatrix-polyphosphazene nanoparticles from non-aromatic monomers
Huang, Z., Zheng, F., Chen, S., Lü, X., van Sittert, C. G. C. E., & Lu, Q. (2016) · RSC Advances · doi:10.1039/c6ra13486f · Cited by 13 · see citing works
Qiu, S., Li, S., Tao, Y., Feng, X., Yu, B., Mu, X., Xing, W., Hu, Y. Z., & Jie, G. (2015) · RSC Advances · doi:10.1039/c5ra12264c · Cited by 12 · see citing works
Synthesis and thermal reactivity of a Me3N-stabilized cyclic (alkyl)(amino)oxophosphonium ion
Cui, J., Li, Y., Ganguly, R., & Kinjo, R. (2016) · Inorganica Chimica Acta · doi:10.1016/j.ica.2016.07.046 · Cited by 12 · see citing works
Structural and fluorescence properties of 2-naphthylamine substituted cyclotriphosphazenes
Çiftçi, G. Y., Şenkuytu, E., Durmuş, M., Yüksel, F., & Kılıç, A. (2014) · Inorganica Chimica Acta · doi:10.1016/j.ica.2014.09.001 · Cited by 12 · see citing works
- Authors
- Allcock, H. R., & Morozowich, N. L.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Allcock, Harry R.
- ORCID
- Allcock, Harry R.
- Venue
- Polym. Chem.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 3
- Issue
- 3
- Pages
- 578-590
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W1975475423
- Cited by
- 152
- References
- 112
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 14 · 2022: 6 · 2021: 6 · 2020: 14 · 2019: 12 · 2018: 18 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 11 · 2012: 5
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Polymer Chemistry (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- polyphosphazenes, bioerodible polymers, biodegradation, biodegradable polymers, biomedical polymers
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