The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Double spiral microchannel for label-free tumor cell separation and enrichment
Abstract
This work reports on a passive double spiral microfluidic device allowing rapid and label-free tumor cell separation and enrichment from diluted peripheral whole blood, by exploiting the size-dependent hydrodynamic forces. A numerical model is developed to simulate the Dean flow inside the curved geometry and to track the particle/cell trajectories, which is validated against the experimental observations and serves as a theoretical foundation for optimizing the operating conditions. Results from separating tumor cells (MCF-7 and Hela) spiked into whole blood indicate that 92.28% of blood cells and 96.77% of tumor cells are collected at the inner and the middle outlet, respectively, with 88.5% tumor recovery rate at a throughput of 3.33 × 10(7) cells min(-1). We expect that this label-free microfluidic platform, driven by purely hydrodynamic forces, would have an impact on fundamental and clinical studies of circulating tumor cells.
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Cites
Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0378 · Cited by 2,542
Cited by
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Zhang, J., Yan, S., Yuan, D., Alici, G., Nguyen, N.-T., Ebrahimi Warkiani, M., & Li, W. (2016) · Lab on a Chip · doi:10.1039/c5lc01159k · Cited by 1,017
Amini, H., Lee, W., & Di Carlo, D. (2014) · Lab on a Chip · doi:10.1039/c4lc00128a · Cited by 722
Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
Warkiani, M. E., Guan, G., Luan, K. B., Lee, W. C., Bhagat, A. A. S., Kant Chaudhuri, P., Tan, D. S.-W., Lim, W. T., Lee, S. C., Chen, P. C. Y., et al. (2014) · Lab Chip · doi:10.1039/c3lc50617g · Cited by 573
Tunable Rigidity of (Polymeric Core)–(Lipid Shell) Nanoparticles for Regulated Cellular Uptake
Sun, J., Zhang, L., Wang, J., Feng, Q., Liu, D., Yin, Q., Xu, D., Wei, Y., Ding, B., Shi, X., et al. (2015) · Advanced Materials · doi:10.1002/adma.201404788 · Cited by 486
Self-citationGuan, G., Wu, L., Bhagat, A. A., Li, Z., Chen, P. C. Y., Chao, S., Ong, C. J., & Han, J. (2013) · Scientific Reports · doi:10.1038/srep01475 · Cited by 279
Metadata
- Authors
- Sun, J., Li, M., Liu, C., Zhang, Y., Liu, D., Liu, W., Hu, G., & Jiang, X.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 12
- Issue
- 20
- Pages
- 3952
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2030593367
- Cited by
- 293
- References
- 1
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sun, J., Li, M., Liu, C., Zhang, Y., Liu, D., Liu, W., Hu, G., & Jiang, X. (2012). Double spiral microchannel for label-free tumor cell separation and enrichment. Lab on a Chip. https://doi.org/10.1039/c2lc40679a
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