The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation
Open accessAbstract
The paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral inertial microfluidic systems. The results confirm that particles are focused near the top and bottom walls of the microchannel cross-section, revealing clear insights on the focusing and separation mechanism. Based on this detailed understanding of the force balance, we introduce a novel spiral microchannel with a trapezoidal cross-section that generates stronger Dean vortices at the outer half of the channel. Experiments show that particles focusing in such device are sensitive to particle size and flow rate, and exhibits a sharp transition from the inner half to the outer half equilibrium positions at a size-dependent critical flow rate. As particle equilibration positions are well segregated based on different focusing mechanisms, a higher separation resolution is achieved over conventional spiral microchannels with rectangular cross-section.
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Cites
Continuous inertial focusing, ordering, and separation of particles in microchannels
Di Carlo, D., Irimia, D., Tompkins, R. G., & Toner, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704958104 · Cited by 1,708
Continuous Particle Separation Through Deterministic Lateral Displacement
Huang, L. R., Cox, E. C., Austin, R. H., & Sturm, J. C. (2004) · Science · doi:10.1126/science.1094567 · Cited by 1,634
Di Carlo, D. (2009) · Lab on a Chip · doi:10.1039/b912547g · Cited by 1,627
Label-free cell separation and sorting in microfluidic systems
Gossett, D. R., Weaver, W. M., Mach, A. J., Hur, S. C., Tse, H. T. K., Lee, W., Amini, H., & Di Carlo, D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3721-9 · Cited by 930
Continuous flow separations in microfluidic devices
Pamme, N. (2007) · Lab on a Chip · doi:10.1039/b712784g · Cited by 770
Yamada, M., Nakashima, M., & Seki, M. (2004) · Analytical Chemistry · doi:10.1021/ac049863r · Cited by 746
Inertial microfluidics for continuous particle separation in spiral microchannels
Kuntaegowdanahalli, S. S., Bhagat, A. A. S., Kumar, G., & Papautsky, I. (2009) · Lab on a Chip · doi:10.1039/b908271a · Cited by 708
Self-citationContinuous particle separation in spiral microchannels using dean flows and differential migration
Bhagat, A. A. S., Kuntaegowdanahalli, S. S., & Papautsky, I. (2008) · Lab on a Chip · doi:10.1039/b807107a · Cited by 656
Self-citationFree Flow Acoustophoresis: Microfluidic-Based Mode of Particle and Cell Separation
Petersson, F., Åberg, L., Swärd-Nilsson, A.-M., & Laurell, T. (2007) · Analytical Chemistry · doi:10.1021/ac070444e · Cited by 649
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
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Cited by
Fundamentals and applications of inertial microfluidics: a review
Zhang, J., Yan, S., Yuan, D., Alici, G., Nguyen, N.-T., Ebrahimi Warkiani, M., & Li, W. (2016) · Lab on a Chip · doi:10.1039/c5lc01159k · Cited by 1,017
Amini, H., Lee, W., & Di Carlo, D. (2014) · Lab on a Chip · doi:10.1039/c4lc00128a · Cited by 722
Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
Warkiani, M. E., Guan, G., Luan, K. B., Lee, W. C., Bhagat, A. A. S., Kant Chaudhuri, P., Tan, D. S.-W., Lim, W. T., Lee, S. C., Chen, P. C. Y., et al. (2014) · Lab Chip · doi:10.1039/c3lc50617g · Cited by 573
Self-citationAbdulla, A., Liu, W., Gholamipour-Shirazi, A., Sun, J., & Ding, X. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04210 · Cited by 131
Recent advances in microfluidic methods in cancer liquid biopsy
Iliescu, F. S., Poenar, D. P., Yu, F., Ni, M., Chan, K. H., Cima, I., Taylor, H. K., Cima, I., & Iliescu, C. (2019) · Biomicrofluidics · doi:10.1063/1.5087690 · Cited by 51
Metadata
- Authors
- Guan, G., Wu, L., Bhagat, A. A., Li, Z., Chen, P. C. Y., Chao, S., Ong, C. J., & Han, J.
- Venue
- Scientific Reports
- Published
- 2013-03-18
- Volume
- 3
- Issue
- 1
- Pages
- 1475-1475
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2043639266
- Cited by
- 279
- References
- 27
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guan, G., Wu, L., Bhagat, A. A., Li, Z., Chen, P. C. Y., Chao, S., Ong, C. J., & Han, J. (2013). Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation. Scientific Reports. https://doi.org/10.1038/srep01475
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
