The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy
Abstract
Upconversion nanoparticles (UCNPs), particularly lanthanide-doped nanocrystals, which emit high energy photons under excitation by the near-infrared (NIR) light, have found potential applications in many different fields, including biomedicine. Compared with traditional down-conversion fluorescence imaging, the NIR light excited upconversion luminescence (UCL) imaging relying on UCNPs exhibits improved tissue penetration depth, higher photochemical stability, and is free of auto-fluorescence background, which promises biomedical imaging with high sensitivity. On the other hand, the unique upconversion process of UCNPs may be utilized to activate photosensitive therapeutic agents for applications in cancer treatment. Moreover, the integration of UCNPs with other functional nanostructures could result in the obtained nanocomposites having highly enriched functionalities, useful in imaging-guided cancer therapies. This review article will focus on the biomedical imaging and cancer therapy applications of UCNPs and their nanocomposites, and discuss recent advances and future prospects in this emerging field.
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Citations
Cites
Design of polymeric nanoparticles for biomedical delivery applications
Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717
Freestanding palladium nanosheets with plasmonic and catalytic properties
Huang, X., Tang, S., Mu, X., Dai, Y., Chen, G., Zhou, Z., Ruan, F., Yang, Z., & Zheng, N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.235 · Cited by 1,602
Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.053 · Cited by 301
Cited by
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,075
Current advances in lanthanide ion (Ln3+)-based upconversion nanomaterials for drug delivery
Yang, D., Ma, P., Hou, Z., Cheng, Z., Li, C., & Lin, J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00155a · Cited by 743
Yin, P. T., Shah, S., Chhowalla, M., & Lee, K.-B. (2015) · Chemical Reviews · doi:10.1021/cr500537t · Cited by 718
Li, X., Zhang, F., & Zhao, D. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00163j · Cited by 615
Metadata
- Authors
- Cheng, L., Wang, C., & Liu, Z.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 5
- Issue
- 1
- Pages
- 23-37
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2027669232
- Cited by
- 359
- References
- 3
- FWCI
- 18.97
- Type
- journal article
- Language
- en
- Open access
- closed
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