Multiple stimuli-responsive polymeric micelles for controlled release
Abstract
Multiple stimuli-responsive polymeric micelles that can respond to light, temperature and pH have been prepared by a novel polymer, pyrene-functionalized poly (dimethylaminoethyl methacrylate), where the pyrene-quaternized segments form a light-responsive shell and the unquaternized segments form a temperature/pH-responsive core. Under UV irradiation, the micelles could be dissociated; when the temperature increased above the lower critical solution temperature, the micelles shrunk. At pH 3, the micelles could be swelled/dissociated and at pH 10, the micelles could be collapsed to complex micelles. The controlled release of Nile Red from the micelle under stimuli was demonstrated. This novel multiple stimuli-responsive micelle shows potential as a new nanocarrier and delivery system.
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Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
- Authors
- Dong, J., Wang, Y., Zhang, J., Zhan, X., Zhu, S., Yang, H., & Wang, G.
- Affiliations
- University of Science and Technology Beijing (CN)
- Peking University (CN)
- Beijing Tongren Hospital (CN)
- Corresponding author
- Yang, Huai
- Wang, Guojie
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 9
- Issue
- 2
- Pages
- 370-373
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2068790670
- Cited by
- 116
- References
- 32
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 17 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 9
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Soft Matter (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- polymeric micelles, stimuli-responsive micelles, multiple stimuli, pyrene, PDMAEMA, lower critical solution temperature, micelle dissociation, micelle swelling, controlled release, nanocarriers, drug delivery
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