Cited by 116Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationHydrogels: synthesis, properties, applications

Multiple stimuli-responsive polymeric micelles for controlled release

Dong, Jie, Wang, Yani, Zhang, Jian, Zhan, Xiaowei, Zhu, Siquan, Yang, Huai, Wang, Guojie·2013·Soft Matter

Abstract

Multiple stimuli-responsive polymeric micelles that can respond to light, temperature and pH have been prepared by a novel polymer, pyrene-functionalized poly (dimethylaminoethyl methacrylate), where the pyrene-quaternized segments form a light-responsive shell and the unquaternized segments form a temperature/pH-responsive core. Under UV irradiation, the micelles could be dissociated; when the temperature increased above the lower critical solution temperature, the micelles shrunk. At pH 3, the micelles could be swelled/dissociated and at pH 10, the micelles could be collapsed to complex micelles. The controlled release of Nile Red from the micelle under stimuli was demonstrated. This novel multiple stimuli-responsive micelle shows potential as a new nanocarrier and delivery system.

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Crossref · 10.1039/c2sm27116h

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32 of 32 references verified0 citation errors · 0 not checkable

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Authors
Dong, J., Wang, Y., Zhang, J., Zhan, X., Zhu, S., Yang, H., & Wang, G.
Affiliations
  • University of Science and Technology Beijing (CN)
  • Peking University (CN)
  • Beijing Tongren Hospital (CN)
Corresponding author
  • Yang, Huai
  • Wang, Guojie
Venue
Soft Matter
Published
2013
Volume
9
Issue
2
Pages
370-373
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2068790670
Cited by
116
References
32
Citations by year
2026: 5 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 17 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 9
FWCI
4.93
Type
journal article
Language
en
Open access
closed
Locations
Soft Matter (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
polymeric micelles, stimuli-responsive micelles, multiple stimuli, pyrene, PDMAEMA, lower critical solution temperature, micelle dissociation, micelle swelling, controlled release, nanocarriers, drug delivery

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