The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
The path for metal complexes to a DNA target
Open accessAbstract
The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe first structural studies of complexes bound covalently and non-covalently to DNA to identify potential lesions within the cell. We then review the biological fates of these complexes, illustrating the key elements in obtaining potent activity, the importance of uptake and subcellular localization of the complexes, as well as the techniques used to delineate these characteristics. Genomic DNA provides a challenging but valuable target for new transition metal-based therapeutics.
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Cites
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Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,805
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A molecular light switch for DNA: Ru(bpy)2(dppz)2+
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Self-citationMammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
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Metadata
- Authors
- Komor, A. C., & Barton, J. K.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 49
- Issue
- 35
- Pages
- 3617
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2095084300
- Cited by
- 384
- References
- 65
- FWCI
- 17.86
- Type
- journal article
- Language
- en
- Open access
- green
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