Understanding Immune‐Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform

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Noninvasive prenatal diagnosis targeting fetal nucleated red blood cells

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Revealing the clinical potential of high-resolution organoids

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Aging phenotype in AD brain organoids: Track to success and challenges

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Organoid-driven nanomedicine platform development

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Organoids in concert: engineering in vitro models toward enhanced fidelity

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Microphysiological systems for human aging research

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Acoustofluidic assembly of primary tumor-derived organotypic cell clusters for rapid evaluation of cancer immunotherapy

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Bioelectronic Interfaces and Sensors for Neural Organoids

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3D printed microfluidics for cell biological applications

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The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases

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Bone Marrow‐Derived GCA+ Immune Cells Drive Alzheimer's Disease Progression

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Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

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Patient-Derived Organoids on a Microarray for Drug Resistance Study in Breast Cancer

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Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis

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Modelling the innate immune system in microphysiological systems

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Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems

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Engineering blood–brain barrier microphysiological systems to model Alzheimer's disease monocyte penetration and infiltration

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Modular Microfluidics: A Systematic Review of Assembly-Based Categorization and Biological Applications

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Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids

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Bioengineering tools for next-generation neural organoids

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Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems

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Immunosenescence and organoids: pathophysiology and therapeutic opportunities

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The impact of aging on HIV-1-related neurocognitive impairment

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Transformative advances in modeling brain aging and longevity: Success, challenges and future directions

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Human Brain Organoids: Development and Applications

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Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening

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Organoid: a promising solution to current challenges in cancer immunotherapy

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Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review

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Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic

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Acoustofluidics

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Mannan-binding lectin inhibits oxidative stress-induced senescence via the NAD+/Sirt1 pathway

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Biofabrication of brain-like living tissue: structure to intelligence

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More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease

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Human cerebral organoids: Complex, versatile, and human-relevant models of neural development and brain diseases

Coronel, R., González-Sastre, R., Mateos-Martínez, P., Maeso, L., Llorente-Beneyto, E., Martín-Benito, S., Gagosian, V. S. C., Foti, L., González, M. D. C., López-Alonso, V., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01639 · Cited by 5 · see citing works

The current approaches to modeling the brain ischemia–reperfusion and inflammation: from animal models toward vascularized and neuroimmune cerebral organoids

Tregub, P. P., Volegova, D. D., Berdnikov, A. K., Chekulaev, P. A., Bystrov, D. A., Komleva, Y. K., Kolotyeva, N. A., Illarioshkin, S. N., Salmina, A. B., & Yurchenko, S. O. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0015 · Cited by 4 · see citing works

Engineering human organoids for biomedical applications: materials, technologies, and translational potential

Gao, Y., Yang, Z., Zhu, L., Long, C., Li, F., Jia, X., Chen, R., & Cai, Z. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.173637 · Cited by 3 · see citing works

Organoid-Immune Co-Cultures: A Next-Generation approach to disease modeling

Najafi, F., Zoghi, N. A., Khalili, H., Najafi, N., Yazdi, M. H., & Sisakht, M. M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11450-5 · Cited by 3 · see citing works

Organoids: generation strategies, applications, and future challenges

Yin, H., Zhu, G., Hai-zhan, W., Yang, B., Wang, Z., & Xie, H. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05045-x · Cited by 3 · see citing works

Publisher's note

Li, K., Gu, L., Cai, H., Lu, H., Mackie, K., & Guo, F. (2024) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2024.101031 · Cited by 3 · see citing works

Brain organoid-on-a-chip to create multiple domains in forebrain organoidsPreprint

Tsai, Y., Ozaki, H., Morikawa, A., Shiraiwa, K., Pin, A. P., Salem, A. G., Phommahasay, K. A., Sugita, B. K., Vu, C. H., Hammad, S. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.18.558278 · Cited by 3 · see citing works

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human brain organoid microphysiological systemsPreprint

Tian, C., Ao, Z., Cerneckis, J., Cai, H., Chen, L., Niu, H., Takayama, K., Kim, J., Shi, Y., Gu, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.16.638539 · Cited by 3 · see citing works

Towards learning and memory risk assessment with human brain organoids: barriers and opportunities

Mohapatra, R., Din, D. A. E., Zhao, H., Härtung, T., & Smirnova, L. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1783893 · Cited by 3 · see citing works

Vascular network-inspired diffusible scaffolds for engineering functional neural organoidsPreprint

Cai, H., Tian, C., Chen, L., McCracken, K. W., Tchieu, J. H., Gu, M., Mackie, K., & Guo, F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.31.610649 · Cited by 2 · see citing works

Organoids: Key advances, optimization, and technological iterations in their application to neurodegenerative diseases

Zhao, J., Wang, J., & Guo, X. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00924 · Cited by 1 · see citing works

Microglia at the core of brain inflammaging: advanced in vitro and neuroimmune organoid platforms for neurotheranostics

Komleva, Y. K., Satish, A., Berdnikov, A. K., Rozanova, N. A., Kolotyeva, N. A., Tregub, P. P., Saridis, M. R., Yurchenko, S. O., & Salmina, A. B. (2026) · The European Physical Journal Special Topics · doi:10.1140/epjs/s11734-026-02209-x · Cited by 2 · see citing works

Engineering Human Retinal Organoids and Eye-on-a-Chip Models for Degenerative Eye Disease

Wang, J., Yang, Y., Hong, Z., Xing, Y., Gu, M., Sharma, T. P., Meyer, J. S., & Guo, F. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c02202 · Cited by 1 · see citing works

Advances in hiPSC ‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease

Maciel, E. M. A., Silva, N. C., Santos, L. G. P., & Ribeiro, F. M. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70416 · Cited by 1 · see citing works

Decoding triple negative breast cancer bone metastasis: from 3D bioprinted models to clinical translation

Xu, J., Kang, Y. Y., Kedong, S., Fan, J., & Liu, Y. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04655-0 · Cited by 1 · see citing works

Mechanics of morphogenesis in neural development: In vivo, in vitro, and in silico

Sutlive, J., Seyyedhosseinzadeh, H., Ao, Z., Xiu, H., Choudhury, S., Gou, K., Guo, F., & Chen, Z. (2023) · Brain Multiphysics · doi:10.1016/j.brain.2022.100062

Additional file 1 of Acoustofluidic assembly of primary tumor-derived organotypic cell clusters for rapid evaluation of cancer immunotherapy

Wu, Z., Ao, Z., Cai, H., Li, X., Chen, B., Tu, H., Wang, Y., Lu, R. O., Gu, M., Cheng, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26566340

Brain organoids as versatile models for neurotropic virus research

Mai, N. T. Q., & Moon, B.-S. (2025) · Organoid · doi:10.51335/organoid.2025.5.e10

Erzhi pills: a potential aging-modulating agent targeting immunosenescence in mice

Fang, Z., Sun, W., Li, N., Shi, T., Ren, X., Zhang, R., Zhang, Y., Chen, J., Liu, Q., Wang, M., et al. (2026) · Biogerontology · doi:10.1007/s10522-026-10387-3

Modeling sporadic Alzheimer’s disease using brain organoids: Emerging trends and translational opportunities

Hossain, M. K., & Kim, H. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103443

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Xing, Y., Yang, Y., Hong, Z., Tian, C., Chu, H., Prokop, S., Cai, H., Gu, M., Tchieu, J. H., Mackie, K., et al. (2026) · Advanced Science · doi:10.1002/advs.75444

Bioengineering strategies to interrogate and modulate the aging immune system

Nikolich‐Žugich, J., Wolf, M. T., Pompano, R. R., & Maisel, K. (2026) · Nature Aging · doi:10.1038/s43587-026-01187-y

AI‐Enabled Organoid Chips for Modeling and Decoding Nerve‐Tumor Interactions

Han, J., Meng, F., Ding, J., Chen, J., Wang, L., & Shi, C. (2026) · Advanced Functional Materials · doi:10.1002/adfm.78364

Organoids for modeling cellular senescence and age-related pathology: From experimental reconstruction to mechanistic and translational applications

Yang, Z., Sun, H., Zhang, F., Ji, W., 梁又德, Wang, M., Yan, M., Zhao, Z., & Fu, L. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103408

Immunocompetent Brain Organoids with Microglia Allow Advanced Aging Research

Ferreira, R. O., Assoni, A. F., da Silva, M. V. R., Rocha, L. A., de Castro, M. V., Bertola, D. R., & Zatz, M. (2024) · Methods in molecular biology · doi:10.1007/7651_2024_565 · Cited by 2 · see citing works

Robust Tissue Fabrication for Long-Term Culture of iPSC-Derived Brain Organoids for Aging Research

Koch, L. S., Buentello, D. C., & Broersen, K. (2023) · Journal of Visualized Experiments · doi:10.3791/64586 · Cited by 8 · see citing works

Exploring aging interventions in human brain organoids

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DEVELOPMENT OF ORGANOID BASED MODEL TO STUDY IMMUNE-NEURAL INTERACTIONS IN HUMAN CNS DISEASESPreprint

Kocot, J., Pradhan, S. H., Maric, D., Kosa, P., Winkler, C. W., Oguz, C., Myers, T. G., Wigerblad, G., Lack, J., Haigh, C. L., et al. (2026) · medRxiv · doi:10.64898/2026.08.14.26360461

Neuroimmune dynamics and brain aging: mechanisms and consequences

Müller, L., Benedetto, S. D., & Müller, V. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1715045 · Cited by 22 · see citing works