The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
Abstract
Covering: 2000 to 2013. Oxidative stress is the central component of chronic diseases. The nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway is vital in the up-regulation of cytoprotective genes and enzymes in response to oxidative stress and treatment with certain dietary phytochemicals. Herein, we classify bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing Nrf2 to provide favorable effects in experimental models of chronic diseases. Moreover, pharmacological inhibition of Nrf2 signalling has emerged as promising strategy against multi-drug resistance thereby improving the treatment efficacy. We have also enlisted natural product-derived inhibitors of Nrf2/ARE pathway.
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Cites
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Nrf2 at the heart of oxidative stress and cardiac protection
Chen, Q. M., & Maltagliati, A. J. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00041.2017 · Cited by 474
Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection
García-Niño, W. R., & Zazueta, C. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.04.008 · Cited by 274
Grishanova, A. Y., & Perepechaeva, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126719 · Cited by 130
Metadata
- Authors
- Kumar, H., Kim, I.-S., More, S. V., Kim, B.-W., & Choi, D.-K.
- Venue
- Nat. Prod. Rep.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 31
- Issue
- 1
- Pages
- 109-139
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2100123437
- Cited by
- 333
- References
- 45
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
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