Cited by 132Toxic Organic Pollutants ImpactGenomics, phytochemicals, and oxidative stressPharmacogenetics and Drug Metabolism

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

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Grishanova, Alevtina Y., Perepechaeva, Maria L.·2022·International Journal of Molecular Sciences

Abstract

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease. In past decades, evidence has accumulated that AhR is associated with the cellular response to oxidative stress, and this property of AhR must be taken into account during investigations into a mechanism of action of xenobiotics that is able to activate AhR or that is susceptible to metabolic activation by enzymes encoded by the genes that are under the control of AhR. In this review, we examine various mechanisms by which AhR takes part in the oxidative-stress response, including antioxidant and prooxidant enzymes and cytochrome P450. We also show that AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.

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  1. [270]Gemma C. Vila J. Bachstetter A. Bickford P.C. Oxidative Stress and the Aging Brain: From Theory to Prevention Brain Aging: Models, Methods, and Mechanisms Riddle D.R. Frontiers in Neuroscience Boca Raton, FL, USA 2007 21204345

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Authors
Grishanova, A. Y., & Perepechaeva, M. L.
Affiliations
Federal Research Center of Fundamental and Translational Medicine (RU)
Corresponding author
Perepechaeva, Maria L.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2022-06-16
Volume
23
Issue
12
Pages
6719
ISSN
1422-0067 (ISSN-L)
OpenAlex
W4283017800
Cited by
130
References
379
Citations by year
2026: 38 · 2025: 39 · 2024: 32 · 2023: 19 · 2022: 2
FWCI
2.24
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
budgetary financing project (FGMU-2022-0004, N1021050601082-2-1.6.4;3.1.6)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
aryl hydrocarbon receptor, oxidative stress, xenobiotic metabolism, cytochrome P450, antioxidant enzymes, redox signaling, transcriptional regulation, therapeutic target, pathogenesis
MeSH terms
Gene Expression Regulation, Humans, Xenobiotics, Reactive Oxygen Species, Receptors, Aryl Hydrocarbon, Oxidative Stress

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