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Cited by 312

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Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences

Chen, Wei, Lin, Hao, Chou, Kuo-Chen·2015·Molecular BioSystems

Abstract

With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent to develop automated methods for analyzing the relationship between the sequences and their functions. Towards this goal, a series of sequence-based methods have been proposed and applied to analyze various character-unknown DNA/RNA sequences in order for in-depth understanding their action mechanisms and processes. Compared with the classical sequence-based methods, the pseudo nucleotide composition or PseKNC approach developed very recently has the following advantages: (1) it can convert length-different DNA/RNA sequences into dimension-fixed digital vectors that can be directly handled by all the existing machine-learning algorithms or operation engines; (2) it can contain the desired features and properties according to the selection or definition of users; (3) it can cover considerable sequence pattern information, both local and global. This minireview is focused on the concept of pseudo nucleotide composition, its development and applications.

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Metadata

Authors
Chen, W., Lin, H., & Chou, K.-C.
Venue
Molecular BioSystems
Published
2015-06-05
Volume
11
Issue
10
Pages
2620-2634
ISSN
  • 1742-2051 (ISSN-L)
  • 1742-206X
OpenAlex
W1943237984
Cited by
312
References
3
FWCI
20.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences. https://app.cochat.ai/papers/10.1039/c5mb00155b
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Chen, W., Lin, H., & Chou, K.-C. (2015). Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences. Molecular BioSystems. https://doi.org/10.1039/c5mb00155b

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