Microparticulate/nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway
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Solid-state respirable particle engineering design, physicochemical characterization, & in vitro aerosolization of advanced microparticulate/nanoparticulate dry powder inhalers targeting the lung Nrf2/Keap-1 pathway.
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Dimethyl fumarate, an antioxidant Nrf2 activator, is capable of reaching lower airways to treat inflammation.
“Furthermore, dimethyl fumarate, an antioxidant Nrf2 activator, is capable of reaching the lower airways to treat inflammation in this region.186”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [186]
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Self-citationD’Amato, A., Altomare, A., Gilardoni, E., Baron, G., Carini, M., Melloni, E., Padoani, G., Vailati, S., Caponetti, G., & Aldini, G. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103374 · Cited by 8 · see citing works
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Beeraka, N. M., Zhou, R., Wang, X., R, H. V. P., Kumar, T. P., Liu, J., Greeshma, M. V., Mandal, S. P., Gurupadayya, B., & Fan, R. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s364693 · Cited by 5 · see citing works
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OXIDATIVE STRESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
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Sofi, H. S., Lora, A. J., Aggarwal, S., Infanger, D. W., Lawrence, B. D., & Mansour, H. M. (2025) · ACS Omega · doi:10.1021/acsomega.4c08514 · Cited by 1 · see citing works
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Innovative Dual Combination Cospray-Dried Rock Inhibitor/ l -Carnitine Inhalable Dry Powder Aerosols
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Self-citationEncinas-Basurto, D., Muralidharan, P., Islam, M. D. S., Vallorz, E. L., Black, S. M., Kraft, M., Ledford, J. G., & Mansour, H. M. (2025) · RSC Pharmaceutics · doi:10.1039/d4pm00265b
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Self-citationJafari, A., Manzari‐Tavakoli, A., Tavakoli, M. M., Hashemian, S. M., Jamaati, H., Akhtari, M., Tabarsi, P., & Omrani, M. (2026) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2026.2714060
Precision nanomedicine for pulmonary diseases: from molecular targeting to clinical translation
Deng, Z., Gao, W., Do, J., Aragam, S., Dawd, O., Belthur, M., Shi, D., Kalin, T. V., & Kalinichenko, V. V. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02982-0
- Authors
- Muralidharan, P., Hayes, D., Black, S. M., & Mansour, H. M.
- Affiliations
- University of Arizona (US)
- The Ohio State University (US)
- Corresponding author
- Mansour, Heidi M.
- Venue
- Molecular Systems Design & Engineering
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 1
- Issue
- 1
- Pages
- 48-65
- ISSN
- 2058-9689 (ISSN-L)
- PMC
- PMC5072457
- OpenAlex
- W2295683914
- Cited by
- 62
- References
- 57
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 3 · 2020: 13 · 2019: 5 · 2018: 1 · 2017: 5
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Molecular Systems Design & Engineering (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- Nrf2 activators, Keap1, aerosol deposition, pulmonary drug delivery, acute lung injury, chronic obstructive pulmonary disease, pulmonary hypertension, lung inflammation
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