Cited by 148Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery

Willis, Lauren, Hayes, Don, Mansour, Heidi M.·2012·Lung

Abstract

Therapeutic liposomal powders (i.e., lipospheres and proliposomes) for dry powder inhalation aerosol delivery, formulated with phospholipids similar to endogenous lung surfactant, offer unique opportunities in pulmonary nanomedicine while offering controlled release and enhanced stability. Many pulmonary diseases such as lung cancer, tuberculosis (TB), cystic fibrosis (CF), bacterial and fungal lung infections, asthma, and chronic obstructive pulmonary disease (COPD) could greatly benefit from this type of pulmonary nanomedicine approach that can be delivered in a targeted manner by dry powder inhalers (DPIs). These delivery systems may require smaller doses for efficacy, exhibit reduced toxicity, fewer side effects, controlled drug release over a prolonged time period, and increased formulation stability as inhaled powders. This state-of-the-art review presents these novel aspects in depth.

Integrity signals

Registry

Crossref · 10.1007/s00408-011-9360-x

Cites

115 of 115 references verified0 citation errors · 0 not checkable

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  • The inhalation route is advantageous for pulmonary delivery of anti-TB drugs and requires lower doses to achieve therapeutic effects.

    “In this context, the inhalation route is advantageous for the pulmonary delivery of anti-TB drugs and requires lower doses to achieve therapeutic effects. The pulmonary delivery of drugs is a convenient and effective approach for the treatment of TB.202”

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Authors
Willis, L., Hayes, D., & Mansour, H. M.
Affiliations
  • University of Kentucky (US)
  • Nationwide Children's Hospital (US)
Corresponding author
Mansour, Heidi M.
Venue
Lung
Published
2012-01-25
Volume
190
Issue
3
Pages
251-262
ISSN
  • 0341-2040 (ISSN-L)
  • 1432-1750
OpenAlex
W2081617033
Cited by
148
References
117
Citations by year
2026: 8 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 22 · 2013: 11 · 2012: 2
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Locations
  • Lung (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
lipospheres, proliposomes, dry powder inhaler, phospholipids, pulmonary surfactant, controlled drug release, formulation stability, lung disease, lung cancer, tuberculosis, cystic fibrosis, chronic obstructive pulmonary disease, asthma, pulmonary infection
MeSH terms
Administration, Inhalation, Aerosols, Pharmaceutical Preparations, Humans, Liposomes, Lung, Lung Diseases, Powders, Nanocapsules

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