Cited by 455Electrostatics and Colloid InteractionsAdvanced Polymer Synthesis and CharacterizationHydrogels: synthesis, properties, applications

The pH-responsive behaviour of poly(acrylic acid) in aqueous solution is dependent on molar mass

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Swift, Thomas, Swanson, Linda, Geoghegan, Mark, Rimmer, Stephen·2016·Soft Matter

Abstract

Fluorescence spectroscopy on a series of aqueous solutions of poly(acrylic acid) containing a luminescent label showed that polymers with molar mass, Mn < 16.5 kDa did not exhibit a pH responsive conformational change, which is typical of higher molar mass poly(acrylic acid). Below this molar mass, polymers remained in an extended conformation, regardless of pH. Above this molar mass, a pH-dependent conformational change was observed. Diffusion-ordered nuclear magnetic resonance spectroscopy confirmed that low molar mass polymers did not undergo a conformational transition, although large molar mass polymers did exhibit pH-dependent diffusion.

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Crossref · 10.1039/c5sm02693h

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  • PAA is an anionic synthetic compound, can form pH-responsive hydrogel, swells or dissolves at pH higher than its pKa, and remains collapsed at acidic pH (pH < pKa).

    “Polyacrylic acid (PAA), which is an anionic synthetic compound, can form pH-responsive hydrogel, swells/dissolves at pH higher than its pKa, and remains collapsed at acidic pH (pH < pKa) [123].”

    From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [123]

    The Introduction (page not provided) describes PAA as a pH-responsive polymer that becomes more ionized and expands as pH rises. But the paper studies chains in aqueous solution, not a hydrogel or its dissolution; it also says low-pH PAA is compact but not fully collapsed. The Discussion (page not provided) explicitly says it remains soluble in water at low pH, and the response varies with molar mass. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Swift, T., Swanson, L., Geoghegan, M., & Rimmer, S.
Affiliations
  • University of Bradford (GB)
  • University of Sheffield (GB)
Corresponding author
  • Geoghegan, Mark
  • Rimmer, Stephen
Venue
Soft Matter
Published
2016
Volume
12
Issue
9
Pages
2542-2549
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2288268375
Cited by
455
References
48
Citations by year
2026: 43 · 2025: 48 · 2024: 52 · 2023: 49 · 2022: 46 · 2021: 57 · 2020: 47 · 2019: 46 · 2018: 30 · 2017: 31 · 2016: 6
FWCI
25.76
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Soft Matter (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • Bradford Scholars (University of Bradford) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Engineering and Physical Sciences Research Council
Topics
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
poly(acrylic acid), pH-responsive polymers, molar mass dependence, conformational change, chain conformation, polymer diffusion, aqueous polymer solutions

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