The pH-responsive behaviour of poly(acrylic acid) in aqueous solution is dependent on molar mass
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Fluorescence spectroscopy on a series of aqueous solutions of poly(acrylic acid) containing a luminescent label showed that polymers with molar mass, Mn < 16.5 kDa did not exhibit a pH responsive conformational change, which is typical of higher molar mass poly(acrylic acid). Below this molar mass, polymers remained in an extended conformation, regardless of pH. Above this molar mass, a pH-dependent conformational change was observed. Diffusion-ordered nuclear magnetic resonance spectroscopy confirmed that low molar mass polymers did not undergo a conformational transition, although large molar mass polymers did exhibit pH-dependent diffusion.
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PAA is an anionic synthetic compound, can form pH-responsive hydrogel, swells or dissolves at pH higher than its pKa, and remains collapsed at acidic pH (pH < pKa).
“Polyacrylic acid (PAA), which is an anionic synthetic compound, can form pH-responsive hydrogel, swells/dissolves at pH higher than its pKa, and remains collapsed at acidic pH (pH < pKa) [123].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [123]
The Introduction (page not provided) describes PAA as a pH-responsive polymer that becomes more ionized and expands as pH rises. But the paper studies chains in aqueous solution, not a hydrogel or its dissolution; it also says low-pH PAA is compact but not fully collapsed. The Discussion (page not provided) explicitly says it remains soluble in water at low pH, and the response varies with molar mass. (LLM, conf=0.88)
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- Authors
- Swift, T., Swanson, L., Geoghegan, M., & Rimmer, S.
- Affiliations
- University of Bradford (GB)
- University of Sheffield (GB)
- Corresponding author
- Geoghegan, Mark
- Rimmer, Stephen
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 12
- Issue
- 9
- Pages
- 2542-2549
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2288268375
- Cited by
- 455
- References
- 48
- Citations by year
- 2026: 43 · 2025: 48 · 2024: 52 · 2023: 49 · 2022: 46 · 2021: 57 · 2020: 47 · 2019: 46 · 2018: 30 · 2017: 31 · 2016: 6
- FWCI
- 25.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Soft Matter (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Bradford Scholars (University of Bradford) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Engineering and Physical Sciences Research Council
- Topics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- poly(acrylic acid), pH-responsive polymers, molar mass dependence, conformational change, chain conformation, polymer diffusion, aqueous polymer solutions
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