The DOI matches its Crossref record; 434 of the 434 references it cites were found in a registry or an index.
Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications
Abstract
Iron oxide nanoparticles (NPs) hold great promise for future biomedical applications because of their magnetic properties as well as other intrinsic properties such as low toxicity, colloidal stability, and surface engineering capability. Numerous related studies on iron oxide NPs have been conducted. Recent progress in nanochemistry has enabled fine control over the size, crystallinity, uniformity, and surface properties of iron oxide NPs. This review examines various synthetic approaches and surface engineering strategies for preparing naked and functional iron oxide NPs with different physicochemical properties. Growing interest in designed and surface-engineered iron oxide NPs with multifunctionalities was explored in in vitro/in vivo biomedical applications, focusing on their combined roles in bioseparation, as a biosensor, targeted-drug delivery, MR contrast agents, and magnetic fluid hyperthermia. This review outlines the limitations of extant surface engineering strategies and several developing strategies that may overcome these limitations. This study also details the promising future directions of this active research field.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Zhang, S., Li, J., Wen, T., Xu, J., & Wang, X. (2012) · RSC Advances · doi:10.1039/c2ra22495j · Cited by 74
RetractedControlled growth of monodisperse silica spheres in the micron size range
Stöber, W., Fink, A., & Bohn, E. (1968) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(68)90272-5 · Cited by 14,532
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application
Lu, A., Salabas, E. L., & Schüth, F. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200602866 · Cited by 6,777
The Iron Oxides: Structure, Properties, Reactions, Occurences and Uses
Cornell, R. M., & Schwertmann, U. (2003) · doi:10.1002/3527602097 · Cited by 4,422
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633
Size-Controlled Synthesis of Magnetite Nanoparticles
Sun, S., & Zeng, H. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026501x · Cited by 2,829
Preparation of aqueous magnetic liquids in alkaline and acidic media
Massart, R. (1981) · IEEE Transactions on Magnetics · doi:10.1109/tmag.1981.1061188 · Cited by 2,817
Cao, S.-W., & Zhu, Y.-J. (2010) · Nanoscale Research Letters · doi:10.1007/s11671-010-9742-7 · Cited by 2,357
Cited by
A Promising Approach: Magnetic Nanosystems for Alzheimer’s Disease Theranostics
Chaparro, C. I. P., Simões, B. T., Borges, J. P., Castanho, M. A. R. B., Soares, P. I. P., & Neves, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092316 · Cited by 40
Metadata
- Authors
- Wu, W., Jiang, C. Z., & Roy, V. A. L.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 8
- Issue
- 47
- Pages
- 19421-19474
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2536788706
- Cited by
- 417
- References
- 434
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications. https://app.cochat.ai/papers/10.1039/c6nr07542h
- The paper
- Wu, W., Jiang, C. Z., & Roy, V. A. L. (2016). Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications. Nanoscale. https://doi.org/10.1039/c6nr07542h
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
