Cited by 41Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesAlzheimer's disease research and treatments

A Promising Approach: Magnetic Nanosystems for Alzheimer’s Disease Theranostics

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Chaparro, Catarina I. P., Simões, Beatriz T., Borges, João P., Castanho, Miguel A. R. B., Soares, Paula I. P., Neves, Vera·2023·Pharmaceutics

Abstract

Among central nervous system (CNS) disorders, Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and a major cause of dementia worldwide. The yet unclear etiology of AD and the high impenetrability of the blood–brain barrier (BBB) limit most therapeutic compounds from reaching the brain. Although many efforts have been made to effectively deliver drugs to the CNS, both invasive and noninvasive strategies employed often come with associated side effects. Nanotechnology-based approaches such as nanoparticles (NPs), which can act as multifunctional platforms in a single system, emerged as a potential solution for current AD theranostics. Among these, magnetic nanoparticles (MNPs) are an appealing strategy since they can act as contrast agents for magnetic resonance imaging (MRI) and as drug delivery systems. The nanocarrier functionalization with specific moieties, such as peptides, proteins, and antibodies, influences the particles’ interaction with brain endothelial cell constituents, facilitating transport across the BBB and possibly increasing brain penetration. In this review, we introduce MNP-based systems, combining surface modifications with the particles’ physical properties for molecular imaging, as a novel neuro-targeted strategy for AD theranostics. The main goal is to highlight the potential of multifunctional MNPs and their advances as a dual nanotechnological diagnosis and treatment platform for neurodegenerative disorders.

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Authors
Chaparro, C. I. P., Simões, B. T., Borges, J. P., Castanho, M. A. R. B., Soares, P. I. P., & Neves, V.
Affiliations
University of Lisbon (PT)
Corresponding author
  • Soares, Paula I. P.
  • Neves, Vera
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2023-09-13
Volume
15
Issue
9
Pages
2316
ISSN
1999-4923 (ISSN-L)
OpenAlex
W4386748988
Cited by
40
References
165
Citations by year
2026: 15 · 2025: 14 · 2024: 11
FWCI
0.70
Type
journal article
Language
en
Open access
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Funders
  • FCT—Portuguese Foundation for Science and Technology (PTDC/BTM-MAT/2472/2021, LA/P/0037/2020, UIDP/50025/2020, UIDB/50025/2020, SFRH/BD/148588/2019)
  • Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N (PTDC/BTM-MAT/2472/2021, LA/P/0037/2020, UIDP/50025/2020, UIDB/50025/2020, SFRH/BD/148588/2019)
  • Portuguese Foundation for Science and Technology (FCT) (PTDC/BTM-MAT/2472/2021, LA/P/0037/2020, UIDP/50025/2020, UIDB/50025/2020, SFRH/BD/148588/2019)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, magnetic nanoparticles, theranostics, blood-brain barrier, drug delivery, MRI contrast agents, molecular imaging, surface functionalization, neurodegenerative diseases, multifunctional nanocarriers

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