Cancer chemoprevention with dietary phytochemicals

Surh, Young-Joon

doi:10.1038/nrc1189

Cited by 2,955Phytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stressBioactive natural compounds

Cancer chemoprevention with dietary phytochemicals

Surh, Young-Joon·2003·Nature reviews. Cancer

DOI 10.1038/nrc1189

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Abstract

Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals.

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Formononetin, biochanin A, coumestans, genistein, and daidzein, which are low-potency estrogenic molecules known as phytoestrogens, can compete with endogenous estrogens in binding to the estrogen receptors, and thus block their mitogenic effects.
“In particular, formononetin, biochanin A, coumestans, genistein, and daidzein (found in beans and in particular fava beans and lupin), which are low-potency estrogenic molecules (i.e., phytoestrogens), can compete with endogenous estrogens in binding to the estrogen receptors, and thus blocking its mitogenic effects (72).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [72]

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Authors: Surh, Y.-J.
Affiliations: Seoul National University (KR)
Corresponding author: Surh, Young-Joon
ORCID: Surh, Young-Joon
Venue: Nature reviews. Cancer
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 3
Issue: 10
Pages: 768-780
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1189
OpenAlex: W2002801265
Cited by: 2,955
References: 138
Citations by year: 2026: 39 · 2025: 48 · 2024: 66 · 2023: 83 · 2022: 81 · 2021: 127 · 2020: 143 · 2019: 119 · 2018: 115 · 2017: 151 · 2016: 178 · 2015: 194 · 2014: 207 · 2013: 214 · 2012: 194
FWCI: 8.70
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: Conquer Cancer Foundation
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords: chemoprevention, dietary phytochemicals, anticarcinogenic mechanisms, carcinogenesis, edible plants
MeSH terms: Humans, Phytotherapy, Neoplasms, Signal Transduction, Anticarcinogenic Agents, Chemoprevention

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Cancer chemoprevention with dietary phytochemicals

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