Purification, characterization, synthesis, in vivo and in vitro antihypertensive activity of bioactive peptides derived from coconut (Cocos nucifera L.) cake globulin hydrolysates
Abstract
This paper reports the purification, characterization, in vivo and in vitro antihypertensive activity of two novel peptides derived from coconut cake globulin hydrolysates.
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The peptides Pro-Gln-Phe-Tyr-Trp and Val-Val-Leu-Tyr-Arg showed stability against gastrointestinal enzyme digestion and suppressed endothelin-1 content and protected vascular endothelial cells from oxidative damage.
“They also showed relatively good stability against gastrointestinal enzyme digestion and demonstrated the ability to suppress endothelin-1 content and protect vascular endothelial cells from oxidative damage.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [105]
Li et al. identified two antioxidant peptides from defatted coconut cake albumin hydrolysate: Pro-Gln-Phe-Tyr-Trp (739.84 Da) and Val-Val-Leu-Tyr-Arg (648.81 Da).
“Li et al. [105] identified two antioxidant peptides from defatted CCA hydrolysate: Pro-Gln-Phe-Tyr-Trp (739.84 Da) and Val-Val-Leu-Tyr-Arg (648.81 Da).”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [105]
The peptides Pro-Gln-Phe-Tyr-Trp and Val-Val-Leu-Tyr-Arg exhibited non-competitive ACE inhibition with IC50 values of 0.104 ± 0.012 and 0.244 ± 0.026 mg/ml, respectively.
“These peptides exhibited potent non-competitive ACE inhibition with IC50 values of 0.104 ± 0.012 and 0.244 ± 0.026 mg/ml, respectively.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [105]
Cites
An antifungal peptide from the coconut
Wang, H. X., & Ng, T. B. (2005) · Peptides · doi:10.1016/j.peptides.2005.05.009 · Cited by 40 · see citing works
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Zheng, Y., Li, Y., & Li, G. (2019) · RSC Advances · doi:10.1039/c8ra10269d · Cited by 37 · see citing works
Self-citationAjibola, O. O. (2025) · Discover Food · doi:10.1007/s44187-025-00746-3 · Cited by 3 · see citing works
“Li et al. [105] identified two antioxidant peptides from defatted CCA hydrolysate: Pro-Gln-Phe-Tyr-Trp (739.84 Da) and Val-Val-Leu-Tyr-Arg (648.81 Da).”
Influential
- Authors
- Li, Y., Zheng, Y., Zhang, Y., Liu, L., & Zhao, S.
- Affiliations
- Coconut Research Institute (CN)
- Corresponding author
- Zheng, Yajun
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 6
- Issue
- 95
- Pages
- 92688-92698
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W2523624218
- Cited by
- 21
- References
- 1
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- RSC Advances (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- bioactive peptides, antihypertensive effect, protein hydrolysates, peptide purification, peptide characterization, Cocos nucifera
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