Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients
Abstract
Promising effects of fisetin on the inflammation status in colorectal cancer.
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A 100 mg dose of fisetin has been used in a colorectal cancer chemotherapy study and has been shown to reduce inflammatory markers, although numbers were small and no clinical cancer end points were assessed.
“In terms of clinical trials, this 100 mg dose has been used in a colorectal cancer chemotherapy study and has been shown to reduce inflammatory markers, although numbers were small and no clinical cancer end points were assessed [121].”
From Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies (2020) · cites this paper as [121]
There were no safety issues at the 100 mg dose of fisetin in the colorectal cancer chemotherapy study.
“There were no safety issues at this dose”
From Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies (2020) · cites this paper as [121]
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Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
Wyld, L., Bellantuono, I., Tchkonia, T., Morgan, J., Turner, O., Foss, F., George, J., Danson, S., & Kirkland, J. L. (2020) · Cancers · doi:10.3390/cancers12082134 · Cited by 235 · see citing works
“, 2018 [121] Randomised clinical trial of dietary supplement dose of Fisetin Oxaliplatin and capecitabine chemotherapy ± Fisetin 100 mg daily for 7 weeks Colorectal cancer Reduced levels of inflammatory mediators (IL8, CRP and MMP7) in Fisetin group.”
BackgroundThe Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression
Wang, Z., Wang, X., Zou, H., Dai, Z., Feng, S., Zhang, M., Xiao, G., Liu, Z., & Cheng, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01757 · Cited by 73 · see citing works
- Authors
- Farsad-Naeimi, A., Alizadeh, M., Esfahani, A., & Darvish Aminabad, E.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Department of Biology
- Corresponding author
- Alizadeh, Mohammad
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 9
- Issue
- 4
- Pages
- 2025-2031
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2789182618
- Cited by
- 95
- References
- 48
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 12 · 2023: 20 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 7 · 2018: 1
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tabriz University of Medical Sciences
- Topics
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
- Keywords
- fisetin, colorectal cancer, flavonoids, dietary supplementation, inflammation, matrix metalloproteinases, MMP-7, MMP-9, interleukin-8, IL-10, C-reactive protein, chemotherapy, complementary therapy, anticancer agents
- MeSH terms
- Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Antineoplastic Combined Chemotherapy Protocols, Antineoplastic Agents, Phytogenic, C-Reactive Protein, Double-Blind Method, Female, Flavonoids, Humans, Iran, Male, Middle Aged, Neoplasm Staging, Colorectal Neoplasms, Down-Regulation, Interleukin-8, Interleukin-10, Chemotherapy, Adjuvant, Dietary Supplements, Matrix Metalloproteinase 9, Matrix Metalloproteinase 7, Flavonols
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