A polymeric temozolomide nanocomposite against orthotopic glioblastoma xenograft: tumor-specific homing directed by nestin
Abstract
Nanocomposite for comprehensive pharmacokinetic and antitumor potential using transferrin for bypassing BBB and anti-nestin antibody as a homing moiety against glioma.
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Nanocomposites with transferrin and anti-nestin targeting ligands can deliver TMZ to intracerebral glioblastoma xenografts and present favorable pharmacokinetics and anti-cancer potential.
“Such nanocomposites having targeting ligands could deliver TMZ to intracerebral glioblastoma xenografts and present favorable pharmacokinetics and anti-cancer potential.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [169]
Cites
Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609 · see citing works
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273 · see citing works
Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders
Mills, E., Dong, X.-P., Wang, F., & Xu, H. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.09.140 · Cited by 309 · see citing works
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases
Anthony, D. P., Hegde, M., Shetty, S. S., Rafic, T., Mutalik, S., & Rao, B. S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119326 · Cited by 110 · see citing works
Self-citation
- Authors
- Prabhu, S., Goda, J. S., Mutalik, S., Mohanty, B. S., Chaudhari, P., Rai, S., Udupa, N., & Rao, B. S. S.
- Affiliations
- Manipal Academy of Higher Education (IN)
- Tata Memorial Hospital (IN)
- Corresponding author
- Rao, Bola Sadashiva Satish
- ORCID
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 9
- Issue
- 30
- Pages
- 10919-10932
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2727346589
- Cited by
- 54
- References
- 3
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 5 · 2018: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- glioblastoma, temozolomide, polymer nanocomposites, superparamagnetic iron oxide nanoparticles, targeted drug delivery, blood-brain barrier permeability, transferrin, Tween 80, orthotopic xenograft, sustained drug release, tumor targeting, magnetic nanoparticles, SPECT/CT imaging
- MeSH terms
- Temozolomide, Animals, Blood-Brain Barrier, Brain Neoplasms, Dacarbazine, Ferric Compounds, Glioblastoma, Humans, Mice, Inbred BALB C, Mice, SCID, Mice, Inbred NOD, Xenograft Model Antitumor Assays, Cell Line, Tumor, Nanoparticles, Nanocomposites, Nestin, Heterografts
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