Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders
Open accessAbstract
Trace metals such as iron, copper, zinc, manganese, and cobalt are essential cofactors for many cellular enzymes. Extensive research on iron, the most abundant transition metal in biology, has contributed to an increased understanding of the molecular machinery involved in maintaining its homeostasis in mammalian peripheral tissues. However, the cellular and intercellular iron transport mechanisms in the central nervous system (CNS) are still poorly understood. Accumulating evidence suggests that impaired iron metabolism is an initial cause of neurodegeneration, and several common genetic and sporadic neurodegenerative disorders have been proposed to be associated with dysregulated CNS iron homeostasis. This review aims to provide a summary of the molecular mechanisms of brain iron transport. Our discussion is focused on iron transport across endothelial cells of the blood-brain barrier and within the neuro- and glial-vascular units of the brain, with the aim of revealing novel therapeutic targets for neurodegenerative and CNS disorders.
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Evidence from inherited disorders of iron metabolism indicates that neurodegeneration occurs with iron accumulation.
“Evidence from studies on inherited disorders of iron metabolism indicates that neurodegeneration occurs with iron accumulation (Mills et al., 2010).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Mills et al., 2010
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Gu, X., Lai, D., Liu, S., Chen, K., Zhang, P., Chen, B., Huang, G., Cheng, X., & Lu, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.949083 · Cited by 40 · see citing works
- Authors
- Mills, E., Dong, X.-P., Wang, F., & Xu, H.
- Affiliations
- University of Michigan (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Xu, Haoxing
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2009-12-22
- Volume
- 2
- Issue
- 1
- Pages
- 51-64
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- PMC
- PMC2812924
- OpenAlex
- W2140073946
- Cited by
- 309
- References
- 98
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 30 · 2023: 24 · 2022: 21 · 2021: 25 · 2020: 29 · 2019: 22 · 2018: 26 · 2017: 11 · 2016: 14 · 2015: 20 · 2014: 20 · 2013: 20 · 2012: 13
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Future Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS062792)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron homeostasis, neurodegeneration, central nervous system disorders, blood-brain barrier, endothelial cells, neurovascular unit, glial cells, trace metals, therapeutic target
- MeSH terms
- Animals, Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System Diseases, Homeostasis, Humans, Iron, Neuroglia, Neurons, Trace Elements, Oxidative Stress, Neurodegenerative Diseases
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