Cited by 310Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders

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Mills, Eric, Dong, Xian-ping, Wang, Fudi, Xu, Haoxing·2010·Future Medicinal Chemistry

Abstract

Trace metals such as iron, copper, zinc, manganese, and cobalt are essential cofactors for many cellular enzymes. Extensive research on iron, the most abundant transition metal in biology, has contributed to an increased understanding of the molecular machinery involved in maintaining its homeostasis in mammalian peripheral tissues. However, the cellular and intercellular iron transport mechanisms in the central nervous system (CNS) are still poorly understood. Accumulating evidence suggests that impaired iron metabolism is an initial cause of neurodegeneration, and several common genetic and sporadic neurodegenerative disorders have been proposed to be associated with dysregulated CNS iron homeostasis. This review aims to provide a summary of the molecular mechanisms of brain iron transport. Our discussion is focused on iron transport across endothelial cells of the blood-brain barrier and within the neuro- and glial-vascular units of the brain, with the aim of revealing novel therapeutic targets for neurodegenerative and CNS disorders.

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  • Evidence from inherited disorders of iron metabolism indicates that neurodegeneration occurs with iron accumulation.

    “Evidence from studies on inherited disorders of iron metabolism indicates that neurodegeneration occurs with iron accumulation (Mills et al., 2010).”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Mills et al., 2010

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Research works printed but not linked: 2

  1. [33]Sayre LM Perry G Smith MA Redox metals and neurodegenerative disease Curr Opin Chem Biol 1999 3 2 220 225 10226049
  2. [64]Moos T Morgan EH Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid J Neurosci Res 1998 54 4 486 494 9822159

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Authors
Mills, E., Dong, X.-P., Wang, F., & Xu, H.
Affiliations
  • University of Michigan (US)
  • Chinese Academy of Sciences (CN)
Corresponding author
Xu, Haoxing
Venue
Future Medicinal Chemistry
Published
2009-12-22
Volume
2
Issue
1
Pages
51-64
ISSN
  • 1756-8919 (ISSN-L)
  • 1756-8927
OpenAlex
W2140073946
Cited by
309
References
98
Citations by year
2026: 8 · 2025: 15 · 2024: 30 · 2023: 24 · 2022: 21 · 2021: 25 · 2020: 29 · 2019: 22 · 2018: 26 · 2017: 11 · 2016: 14 · 2015: 20 · 2014: 20 · 2013: 20 · 2012: 13
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Future Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (NS062792)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
iron homeostasis, neurodegeneration, central nervous system disorders, blood-brain barrier, endothelial cells, neurovascular unit, glial cells, trace metals, therapeutic target
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System Diseases, Homeostasis, Humans, Iron, Neuroglia, Neurons, Trace Elements, Oxidative Stress, Neurodegenerative Diseases

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