The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration
Abstract
The regeneration of articular cartilage, which scarcely shows innate self-healing ability, is a great challenge in clinical treatment. Stem cell-derived exosomes (SC-Exos), an important type of extracellular nanovesicle, exhibit great potential for cartilage regeneration to replace stem cell-based therapy. Cartilage regeneration often takes a relatively long time and there is currently no effective administration method to durably retain exosomes at cartilage defect sites to effectively exert their reparative effect. Therefore, in this study, we exploited a photoinduced imine crosslinking hydrogel glue, which presents excellent operation ability, biocompatibility and most importantly, cartilage-integration, as an exosome scaffold to prepare an acellular tissue patch (EHG) for cartilage regeneration. It was found that EHG can retain SC-Exos and positively regulate both chondrocytes and hBMSCs in vitro. Furthermore, EHG can integrate with native cartilage matrix and promote cell deposition at cartilage defect sites, finally resulting in the promotion of cartilage defect repair. The EHG tissue patch therefore provides a novel, cell-free scaffold material for wound repair.
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Cites
Repair and tissue engineering techniques for articular cartilage
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Unlike Bone, Cartilage Regeneration Remains Elusive
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Self-citationMultifunctional chondroitin sulphate for cartilage tissue–biomaterial integration
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Cited by
Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2019) · Theranostics · doi:10.7150/thno.29766 · Cited by 908
Yang, J., Chen, Z., Pan, D., Li, H., & Shen, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s249129 · Cited by 522
Chen, P., Zheng, L., Wang, Y., Tao, M., Xie, Z., Xia, C., Gu, C., Chen, J., Qiu, P., Mei, S., et al. (2019) · Theranostics · doi:10.7150/thno.31017 · Cited by 462
Self-citationBrennan, M. Á., Layrolle, P., & Mooney, D. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909125 · Cited by 396
Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370
Metadata
- Authors
- Liu, X., Yang, Y., Li, Y., Niu, X., Zhao, B., Wang, Y., Bao, C., Xie, Z., Lin, Q., & Zhu, L.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 9
- Issue
- 13
- Pages
- 4430-4438
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2593512238
- Cited by
- 465
- References
- 32
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, X., Yang, Y., Li, Y., Niu, X., Zhao, B., Wang, Y., Bao, C., Xie, Z., Lin, Q., & Zhu, L. (2017). Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration. Nanoscale. https://doi.org/10.1039/c7nr00352h
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