The DOI matches its Crossref record.
Unlike Bone, Cartilage Regeneration Remains Elusive
Open accessAbstract
Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Yang, J., Zhang, Y. S., Yue, K., & Khademhosseini, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.036 · Cited by 652
Silk fibroin as a functional biomaterial for tissue engineering
Sun, W., Gregory, D. A., Tomeh, M. A., & Zhao, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031499 · Cited by 552
Injectable alginate hydrogels for cell delivery in tissue engineering
Bidarra, S. J., Barrias, C. C., & Granja, P. L. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.12.006 · Cited by 534
Gao, F., Xu, Z., Liang, Q., Li, H., Peng, L., Wu, M., Zhao, X., Cui, X., Ruan, C., & Liu, W. (2019) · Advanced Science · doi:10.1002/advs.201900867 · Cited by 365
Metadata
- Authors
- Huey, D. J., Hu, J. C., & Athanasiou, K. A.
- Venue
- Science
- Published
- 2012-11-16
- Volume
- 338
- Issue
- 6109
- Pages
- 917-921
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054250836
- Cited by
- 1,182
- References
- 0
- FWCI
- 35.05
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Unlike Bone, Cartilage Regeneration Remains Elusive. https://app.cochat.ai/papers/10.1126/science.1222454
- The paper
- Huey, D. J., Hu, J. C., & Athanasiou, K. A. (2012). Unlike Bone, Cartilage Regeneration Remains Elusive. Science. https://doi.org/10.1126/science.1222454
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
