The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration
Open accessAbstract
PURPOSE: Chronic refractory wounds are a multifactorial comorbidity of diabetes mellitus with the characteristic of impaired vascular networks. Currently, there is a lack of effective treatments for such wounds. Various types of mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to exert multiple therapeutic effects on skin regeneration. We aimed to determine whether a constructed combination of human umbilical cord MSC (hUCMSC)-derived exosomes (hUCMSC-exos) and Pluronic F-127 (PF-127) hydrogel could improve wound healing. MATERIALS AND METHODS: We topically applied human umbilical cord-derived MSC (hUCMSC)-derived exosomes (hUCMSC-exos) encapsulated in a thermosensitive PF-127 hydrogel to a full-thickness cutaneous wound in a streptozotocin-induced diabetic rat model. The material properties and wound healing ability of the hydrogel and cellular responses were analyzed. RESULTS: Compared with hUCMSC-exos, PF-127-only or control treatment, the combination of PF-127 and hUCMSC-exos resulted in a significantly accelerated wound closure rate, increased expression of CD31 and Ki67, enhanced regeneration of granulation tissue and upregulated expression of vascular endothelial growth factor (VEGF) and factor transforming growth factor beta-1 (TGFβ-1). CONCLUSION: The efficient delivery of hUCMSC-exos in PF-127 gel and improved exosome ability could promote diabetic wound healing. Thus, this biomaterial-based exosome therapy may represent a new therapeutic approach for cutaneous regeneration of chronic wounds.
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Cites
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HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing
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Cited by
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications
Feng, P., Luo, Y., Ke, C., Qiu, H., Wang, W., Zhu, Y., Hou, R., Xu, L., & Wu, S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.650598 · Cited by 491
Sabit, H., Pawlik, T. M., Radwan, F., Abdel-Hakeem, M., Abdel-Ghany, S., Wadan, A.-H. S., Elzawahri, M., El-Hashash, A., & Arneth, B. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02357-z · Cited by 239
Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context
Esmaeili, A., Alini, M., Baghaban Eslaminejad, M., & Hosseini, S. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02806-2 · Cited by 94
Saadh, M. J., Ramírez-Coronel, A. A., Saini, R. S., Arias-Gonzáles, J. L., Amin, A. H., Gavilán, J. C. O., & Sârbu, I. (2023) · Human Cell · doi:10.1007/s13577-023-00904-8 · Cited by 30
Metadata
- Authors
- Yang, J., Chen, Z., Pan, D., Li, H., & Shen, J.
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2020-08
- Volume
- Volume 15
- Pages
- 5911-5926
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W3047746754
- Cited by
- 522
- References
- 62
- FWCI
- 27.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, J., Chen, Z., Pan, D., Li, H., & Shen, J. (2020). Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s249129
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