Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity
Abstract
Three new stilbenoids with potential reverse cholesterol transport activity were isolated from the leaves of hemp ( Cannabis sativa L.).
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Cannabis stilbenes are numerous, and many are unique to Cannabis, namely canniprene, cannastilbenes (I, IIa, and IIb), and many spiroindans, including cannabispirone.
“Cannabis stilbenes are numerous, and many are, to date, unique to Cannabis, namely canniprene, cannastilbenes (I, IIa, and IIb), and many spiroindans, including cannabispirone.”
Stilbenes have been reported to be less abundant but contribute to the plant's antioxidative profile and may enhance pharmacological effects of cannabinoids through synergistic interactions.
“Although stilbenes have been reported to be less abundant, they contribute to the plant’s antioxidative profile and may enhance the pharmacological effects of cannabinoids through synergistic interactions [18,19].”
To date, 38 stilbenes have been identified in Cannabis: 7 phenanthrenes, 15 dihydrostilbenes, and 16 spiroindans.
“To date, a total of thirty-eight stilbenes have been identified: seven phenanthrenes, fifteen dihydrostilbenes, and sixteen spiroindans [5,12,19].”
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Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis
Radwan, M. M., Chandra, S., Gul, S., & ElSohly, M. A. (2021) · Molecules · doi:10.3390/molecules26092774 · Cited by 397 · see citing works
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Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa
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- Authors
- Guo, T., Liu, Q., Hou, P., Li, F., Guo, S., Song, W., Zhang, H., Liu, X., Zhang, S., Zhang, J., Ho, C.-T., & Bai, N.
- Affiliations
- Northwest University (CN)
- Weifang Medical University (CN)
- Air Force Medical University (CN)
- China-hemp Research Center
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Liu, Qingchao
- Song, Weiguo
- Bai, Naisheng
- ORCID
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 9
- Issue
- 12
- Pages
- 6608-6617
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2899432163
- Cited by
- 36
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81770463, 31300639)
- Shaanxi University of Science and Technology (2015KJXX-28)
- Education Department of Shaanxi Province (15JK1717, 16JK1768)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Keywords
- stilbenoids, cannabinoids, Cannabis sativa, hemp leaves, reverse cholesterol transport, cytotoxicity, ABCG1, scavenger receptor class B type I, ABCA1, LDL receptor, macrophages, MCF-7 cells, A549 cells, anticancer activity, structure elucidation, natural product isolation, cholesterol efflux, high-density lipoprotein
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily G, Member 1, Biological Transport, Cannabinoids, Cannabis, Cholesterol, Drugs, Chinese Herbal, Humans, Macrophages, Stilbenes, Molecular Structure, Plant Leaves, Cell Line, Tumor, Cell Proliferation, Scavenger Receptors, Class B
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