Multivalent aptamer-modified tetrahedral DNA nanocage demonstrates high selectivity and safety for anti-tumor therapy
Abstract
Multivalent aptamer-modified tetrahedral DNA nanocage demonstrates high selectivity and safety for anti-tumor therapy in vivo .
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MUC1 aptamer-modified tetrahedral DNA nanocages loading doxorubicin reduce uptake in normal cells, improve uptake in breast cancer cells, reduce systemic toxicity, and have tumor suppressor effect.
“Han et al. used complementary base pairing to modify the MUC1 aptamer into tetrahedral DNA nanocages (Td) for self-assembly to load doxorubicin. The complex reduces the uptake rate in normal cells and improves the uptake efficiency in breast cancer cells. This high specificity reduces systemic toxicity and has an effective tumor suppressor effect.252”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [252]
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Han, X., Jiang, Y., Li, S., Zhang, Y., Ma, X., Wu, Z., Wu, Z., & Qi, X.
- Affiliations
- China Pharmaceutical University (CN)
- Nanjing Normal University (CN)
- Corresponding author
- Wu, Zhenghong
- Qi, Xiaole
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 11
- Issue
- 1
- Pages
- 339-347
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2903024684
- Cited by
- 77
- References
- 31
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 6 · 2023: 14 · 2022: 13 · 2021: 6 · 2020: 17 · 2019: 5
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81402859, 51472115)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- DNA nanocages, tetrahedral DNA nanostructures, MUC1 aptamer, DNA origami, doxorubicin delivery, tumor targeting, cellular uptake, MCF-7 cells, systemic toxicity, anti-tumor therapy, nucleic acid self-assembly
- MeSH terms
- Animals, Antineoplastic Agents, DNA, Doxorubicin, Female, Humans, Mice, Nude, Neoplasm Transplantation, Nucleic Acid Conformation, Drug Delivery Systems, Microscopy, Atomic Force, Cell Line, Tumor, Nanostructures, Mice, Aptamers, Nucleotide, Molecular Targeted Therapy, MCF-7 Cells
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