Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging
Abstract
A novel NIR-II small-molecule fluorophore HQL2 for in vivo NIR-IIa and NIR-IIb vascular and tumor vessel imaging.
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The π-spacer plays an important role in tuning the energy levels of D-π-A-π-D chromophores by extending π-conjugation that promotes/stabilizes the quinoid structure or by introducing steric effects to control the overall twist affecting ICT properties.
“As stated above, the π-spacer also plays an important role in tuning the energy levels of the D-π-A-π-D type of chromophores, as it extends the π-conjugation that promotes/stabilizes the quinoid structure or introduces steric effects to control the overall twist affecting the ICT properties of the system.56,58−61”
Cites
Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01682 · Cited by 215 · see citing works
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Perfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394 · see citing works
Liu, S., Ou, H., Li, Y., Zhang, H., Liu, J., Lu, X., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07193 · Cited by 277 · see citing works
Self-citationLiu, S., Chen, R., Zhang, J., Li, Y., He, M., Fan, X., Zhang, H., Lu, X., Kwok, R. T. K., Lin, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c07527 · Cited by 129 · see citing works
Self-citationPiwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
- Authors
- Li, Q., Ding, Q., Li, Y., Zeng, X., Liu, Y., Lu, S., Zhou, H., Wang, X., Wu, J., Meng, X., Deng, Z., & Xiao, Y.
- Affiliations
- Tibet University (CN)
- Wuhan University (CN)
- Hubei Provincial Key Laboratory of Developmentally Originated Disease
- Chengdu University of Traditional Chinese Medicine (CN)
- Corresponding author
- Xiao, Yuling
- ORCID
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 56
- Issue
- 22
- Pages
- 3289-3292
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W3005106864
- Cited by
- 90
- References
- 1
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 23 · 2021: 20 · 2020: 15
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81773674, 21473041, 81573383)
- Chengdu University of Traditional Chinese Medicine (CZYJC1903)
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Hubei Province (2017CFA024, 2016ACA126, 2017CFB711)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- NIR-II fluorescence imaging, small-molecule fluorophores, aggregation-induced emission, vascular imaging, water-soluble nanoparticles, biocompatibility
- MeSH terms
- Animals, Biocompatible Materials, Blood Vessels, Female, Fluorescent Dyes, Humans, Mice, Inbred C57BL, Mice, Nude, Neoplasms, Quantum Theory, Transplantation, Heterologous, Spectroscopy, Near-Infrared, Cell Line, Tumor, Mice, Nanoparticles, Optical Imaging
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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