Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells
Open accessAbstract
DNA origami is a promising molecular delivery system for a variety of therapeutic applications including cancer therapy, given its capability to fabricate homogeneous nanostructures whose physicochemical properties (size, shape, surface chemistry) can be precisely tailored. However, the correlation between DNA-origami design and internalization efficiency in different cancer cell lines remains elusive. We investigated the cellular uptake of four DNA-origami nanostructures (DONs) with programmed sizes and shapes in multiple human cancer cell lines. The cellular uptake efficiency of DONs was influenced by size, shape, and cell line. Scavenger receptors were responsible for the internalization of DONs into cancer cells. We observed distinct stages of the internalization process of a gold nanoparticle (AuNP)-tagged rod-shape DON, using high-resolution transmission electron microscopy. This study provides detailed understanding of cellular uptake and intracellular trafficking of DONs in cancer cells, and offers new insights for future optimization of DON-based drug delivery systems for cancer treatment.
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EM is better suited to the examination of hybrid structures in which DNA is used to create barcodes made of gold nanoparticles.
“As such, EM is better suited to the examination of hybrid structures, wherein the DNA is used to create “barcodes” made of gold nanoparticles,129 for example.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [129]
Different barcodes can be used to track the cellular uptake of various nanostructures because EM allows for the identification of subcellular compartments.
“Different barcodes can then be used to track the cellular uptake of various nanostructures because EM allows for the identification of subcellular compartments.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [129]
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- Authors
- Wang, P., Rahman, M. A., Zhao, Z., Weiss, K., Zhang, C., Chen, Z., Hurwitz, S. J., Chen, Z. G., Shin, D. M., & Ke, Y.
- Affiliations
- Georgia Institute of Technology (US)
- Emory University (US)
- Central South University (CN)
- Corresponding author
- Shin, Dong M.
- Ke, Yonggang
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-12
- Volume
- 140
- Issue
- 7
- Pages
- 2478-2484
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC7261494
- OpenAlex
- W2786092482
- Cited by
- 269
- References
- 45
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 38 · 2023: 38 · 2022: 29 · 2021: 45 · 2020: 28 · 2019: 31 · 2018: 13
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R21EB022828-01A1)
- American Cancer Society (IRG-14-188-0)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- DNA origami, cellular uptake, intracellular trafficking, cancer cells, scavenger receptors, gold nanoparticle labeling, drug delivery systems, cancer therapy, cell line differences
- MeSH terms
- DNA, Gold, Humans, Particle Size, Drug Delivery Systems, Cell Line, Tumor, Metal Nanoparticles
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