Understanding the good and poor cell targeting activity of gold nanostructures functionalized with molecular units for the epidermal growth factor receptor
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The key role of polyethylene glycol is demonstrated.
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We developed a methodology for detecting cancer cells based on sub-nanomolar concentration of nanocolloids functionalized with monoclonal antibodies or engineered targeting peptides.
“We developed a methodology for detecting cancer cells based on sub-nanomolar concentration of nanocolloids functionalized with monoclonal antibodies [147,148] or with engineered targeting peptides [172,180,181,182,183].”
From Nanoparticles Engineering by Pulsed Laser Ablation in Liquids: Concepts and Applications (2020) · cites this paper as [181]
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“We have prepared nanostructures with the following peptides: GE11, which targets epidermal growth factor receptors (EGFRs) expressed in different types of tumors [172,181], RGD for v3 integrin, an adhesion receptor found in tumors at metastatic level [182], targeting and PreS1 for SerpinB3, a protein overexpressed by…”
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Self-citation
- Authors
- Mazzuca, C., Di Napoli, B., Biscaglia, F., Ripani, G., Rajendran, S., Braga, A., Benna, C., Mocellin, S., Gobbo, M., Meneghetti, M., & Palleschi, A.
- Affiliations
- University of Rome Tor Vergata (IT)
- Department of Chemical Science and Technology
- University of Padua (IT)
- Department of Surgery, Oncology and Gastroenterology
- Corresponding author
- Meneghetti, Moreno
- Palleschi, Antonio
- ORCID
- Venue
- Nanoscale Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 1
- Issue
- 5
- Pages
- 1970-1979
- ISSN
- 2516-0230 (ISSN-L)
- PMC
- PMC9417547
- OpenAlex
- W2932173494
- Cited by
- 16
- References
- 44
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nanoscale Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Funders
- Università degli Studi di Padova (04BIRD2016-UNIPD, 08SID2017-UNIPD)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- gold nanoparticles, epidermal growth factor receptor, peptide targeting, GE11 peptide, nanoparticle-cell interactions, cancer theranostics, molecular dynamics simulation, surface functionalization, targeting specificity
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