On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

Fleming, Aaron M.; Burrows, Cynthia J.

doi:10.1039/d0cs00579g

Cited by 136DNA and Nucleic Acid ChemistryRedox biology and oxidative stressFree Radicals and Antioxidants

On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

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Fleming, Aaron M., Burrows, Cynthia J.·2020·Chemical Society Reviews

DOI 10.1039/d0cs00579gPMC PMC7522918

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Carbonate radical anion, not hydroxyl radical, is the principal reactive oxygen species generated from endogenous oxidative stress endowing epigenetic features to guanine oxidation products in DNA.

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CO3·− can be formed via reaction between nitric oxide, NO·, and superoxide radical anion, O2·−, forming peroxynitrite reacting further with CO2.
“Alternatively, CO3·− can be formed via the reaction between nitric oxide, NO·, and superoxide radical anion, O2·−, forming peroxynitrite reacting further with CO2 (see Fig. 2) (Fleming and Burrows 2020; Samuni et al. 2022).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Fleming and Burrows 2020

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Authors: Fleming, A. M., & Burrows, C. J.
Affiliations: University of Utah (US)
Corresponding author: Burrows, Cynthia J.
ORCID: Fleming, Aaron M.
Burrows, Cynthia J.
Venue: Chemical Society Reviews
Publisher: Royal Society of Chemistry (RSC)
Published: 2020
Volume: 49
Issue: 18
Pages: 6524-6528
ISSN: 0306-0012 (ISSN-L)
1460-4744
DOI: 10.1039/d0cs00579g
PMC: PMC7522918
OpenAlex: W3048412391
Cited by: 136
References: 22
Citations by year: 2026: 18 · 2025: 27 · 2024: 24 · 2023: 19 · 2022: 25 · 2021: 22 · 2020: 1
FWCI: 1.60
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: rsc.li/journals-terms-of-use (am, 589 d)
Locations: Chemical Society Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01 CA090689)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: hydroxyl radicals, oxidative DNA damage, carbonate radical anion, Fenton reaction, inflammation, 8-oxo-7,8-dihydroguanine, G-quadruplex, oxidative stress sensing, epigenetic modifications, DNA repair, one-electron oxidation
MeSH terms: DNA, DNA Damage, Hydroxyl Radical, Oxidative Stress, Epigenomics

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On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

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