Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

Vorobyeva, A., Stanton, M., Godinat, A., Lund, K. B., Karateev, G., Francis, K. P., Allen, E., Gelovani, J. G., McCormack, E., Tangney, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131037 · Cited by 46

A fluorescent turn-on probe for nitroreductase imaging in living cells and tissues under hypoxia conditions

Xia, L., Hu, F., Huang, J., Li, N., Gu, Y., & Wang, P. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.04.100 · Cited by 45

A lysosomes-targeted ratio fluorescent probe for real-time monitoring of micropolarity in cancer cells

Wang, Y., Wang, G., Wang, K., Wang, Z., Guo, Y., & Zhang, H. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.01.132 · Cited by 44

A super-sensitive ratiometric fluorescent probe for monitoring intracellular subtle pH fluctuation

Liu, M., Lv, Y., Jie, X., Meng, Z., Wang, X., Huang, J., Peng, A., & Tian, Z. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.06.048 · Cited by 44

A new pH-sensitive fluorescent probe for visualization of endoplasmic reticulum acidification during stress

Xiao, H., Zhang, R., Wu, C., Li, P., Zhang, W., & Tang, B. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.07.059 · Cited by 44

Tracking lysosomal polarity variation in inflamed, obese, and cancer mice guided by a fluorescence sensing strategy

Yin, J., Peng, M., & Lin, W. (2019) · Chemical Communications · doi:10.1039/c9cc04739e · Cited by 44

A near-infrared frequency upconversion probe for nitroreductase detection and hypoxia tumor in vivo imaging

Li, Y., Deng, Y., Liu, J., Fu, J., Sun, Y., Ouyang, R., & Miao, Y. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.02.002 · Cited by 43

A family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarity

Li, L., Xu, Y., Chen, Y., Zheng, J., Zhang, J., Li, R., Wan, H., Yin, J., Yuan, Z., & Chen, H. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.10.061 · Cited by 42

Locked-flavylium fluorescent dyes with tunable emission wavelengths based on intramolecular charge transfer for multi-color ratiometric fluorescence imaging

Chen, H., Lin, W., Jiang, W., Dong, B., Cui, H., & Tang, Y. (2015) · Chemical Communications · doi:10.1039/c5cc01242b · Cited by 41

Endoplasmic reticulum-targeted two-photon turn-on fluorescent probe for nitroreductase in tumor cells and tissues

Xu, A., Tang, Y., & Lin, W. (2018) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2018.05.092 · Cited by 40

A neutral pH probe of rhodamine derivatives inspired by effect of hydrogen bond on pKa and its organelle-targetable fluorescent imaging

Yu, H., Li, G., Zhang, B., Zhang, X., Xiao, Y., Wang, J., & Song, Y. (2016) · Dyes and Pigments · doi:10.1016/j.dyepig.2016.05.028 · Cited by 39

Two-photon fluorescent probe for detection of nitroreductase and hypoxia-specific microenvironment of cancer stem cell

Liu, Y., Liu, W., Li, H., Yan, W., Yang, X., Liu, D., Wang, S., & Zhang, J. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.03.030 · Cited by 39

Fluorescence detection of intracellular pH changes in the mitochondria-associated process of mitophagy using a hemicyanine-based fluorescent probe

Niu, L., Huang, J., Yan, Z.-J., Men, Y., Luo, Y., Zhou, X., Wang, J., & Wang, J. (2018) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2018.09.015 · Cited by 39

A two-photon fluorescent probe for detecting lipid droplet viscosity in living cells and zebra fish

Peng, M., Yin, J., & Lin, W. (2018) · New Journal of Chemistry · doi:10.1039/c8nj04918a · Cited by 39

An activatable NIR fluorescent rosol for selectively imaging nitroreductase activity

Klockow, J., Hettie, K. S., LaGory, E. L., Moon, E. J., Giaccia, A. J., Graves, E. E., & Chin, F. T. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.127446 · Cited by 39

History and Morphology of the Lysosome

Lüllmann‐Rauch, R. (2007) · Springer eBooks · doi:10.1007/0-387-28957-7_1 · Cited by 38

In vitro and in vivo assays to assess the functions of calnexin and calreticulin in ER protein folding and quality control

Paquet, M.-È., Leach, M. R., & Williams, D. B. (2005) · Methods · doi:10.1016/j.ymeth.2004.10.005 · Cited by 37

A photostable AIE fluorogen for lysosome-targetable imaging of living cells

Lou, X., Zhang, M., Zhao, Z., Min, X., Hakeem, A., Huang, F., Gao, P., Xia, F., & Tang, B. Z. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01293k · Cited by 37

Discriminating normal and inflammatory models by viscosity changes with a mitochondria-targetable fluorescent probe

Wang, W., Liu, Y., Niu, J., & Lin, W. (2019) · The Analyst · doi:10.1039/c9an01573f · Cited by 37

Dual-functioning IQ-LVs as lysosomal viscosity probes with red-shifted emission and inhibitors of autophagic flux

Park, J., Lim, B., Lee, N. K., Lee, J. H., Jang, K., Kang, S. W., Kim, S., Kim, I., Hwang, H., & Lee, J. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.127764 · Cited by 37

Dicyanoboron diketonate dyes: Synthesis, photophysical properties and bioimaging

Zhou, Y., Chen, Y., Cao, J.-H., Yang, Q., Wu, L., Tung, C., & Wu, D. (2014) · Dyes and Pigments · doi:10.1016/j.dyepig.2014.07.001 · Cited by 34

A Carborane‐Containing Fluorophore as a Stain of Cellular Lipid Droplets

Wu, A., Kolanowski, J. L., Boumelhem, B. B., Yang, K., Lee, R., Kaur, A., Fraser, S. T., New, E. J., & Rendina, L. M. (2017) · Chemistry - An Asian Journal · doi:10.1002/asia.201700423 · Cited by 34

A new aggregation-induced emission fluorescent probe for rapid detection of nitroreductase and its application in living cells

Xu, G., Tang, Y., Ma, Y., Xu, A., & Lin, W. (2017) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2017.06.065 · Cited by 34

A triazine-based BODIPY trimer as a molecular viscometer

Raut, S., Kimball, J., Fudala, R., Bora, I., Chib, R., Jaafari, H., Castillo, M., Smith, N. W., Gryczyński, I., Dzyuba, S. V., et al. (2016) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp07214j · Cited by 33

Rationally Designed Solvatochromic Fluorescent Indoline Derivatives for Probing Mitochondrial Environment

Pal, K., & Koner, A. L. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201701425 · Cited by 33

Bioluminescent Probe for Tumor Hypoxia Detection via CYP450 Reductase in Living Animals

Gao, Y., Lin, Y., Liu, T., Chen, H., Yang, X., Tian, C., Du, L., & Li, M. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03597 · Cited by 31

A high-selectivity fluorescent probe for hypoxia imaging in cells and a tumor-bearing mouse model

Wang, Y., Han, X., Zhang, X., Zhang, L., & Chen, L. (2020) · The Analyst · doi:10.1039/c9an02436k · Cited by 29

Hemicyanine based naked-eye ratiometric fluorescent probe for monitoring lysosomal pH and its application

Zhang, Y., Zhao, Y., Wu, Y., Zhao, B., Wang, L., & Song, B. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117767 · Cited by 28

A new ratiometric two-photon fluorescent probe for imaging of lysosomes in living cells and tissues

Zhou, L., Liu, Y., Hu, S., Wang, H., Sun, H., & Zhang, X. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.06.038 · Cited by 27

A fast-responsive two-photon fluorescent turn-on probe for nitroreductase and its bioimaging application in living tissues

Xu, A., Tang, Y., Ma, Y., Xu, G., Gao, S., Zhao, Y., & Lin, W. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.06.043 · Cited by 27

Rational design of a novel mitochondrial-targeted near-infrared fluorescent pH probe for imaging in living cells and in vivo

Wang, P., Huang, J., & Gu, Y. (2016) · RSC Advances · doi:10.1039/c6ra22470a · Cited by 26

Two-dimensional carbazole-based derivatives as versatile chemosensors for colorimetric detection of cyanide and two-photon fluorescence imaging of viscosity in vitro

Zhang, W., Xu, K., Yue, L., Shao, Z., Feng, Y., & Fang, M. (2016) · Dyes and Pigments · doi:10.1016/j.dyepig.2016.11.002 · Cited by 26

A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation

Ti, Y., Yu, L., Tang, Y., Jin, T., Ming, Y., Wang, R., Xu, Y. F., & Zhu, W. P. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.02.122 · Cited by 25

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

Liang, H., Bi, Q., Hu, A., Chen, X., Jin, R., Song, X., Ke, B., Barz, M., & Nie, Y. (2020) · Chemical Communications · doi:10.1039/c9cc10071g · Cited by 25

Characteristics of new bioreductive fluorescent probes based on the xanthene fluorophore: Detection of nitroreductase and imaging of hypoxic cells

More, K. N., Lim, T.-H., Kim, S., Kang, J., Inn, K., & Chang, D. (2018) · Dyes and Pigments · doi:10.1016/j.dyepig.2018.01.008 · Cited by 23

A series of water-soluble pyridinium derivatives with two-photon absorption in the near infrared region for mitochondria targeting under stimulated emission depletion (STED) nanoscopy

Tian, X., Hussain, S., Wang, H., Zhang, Q., Zhao, M., Chen, J., Zhang, H., Zhou, H., Chen, Y., & Tian, Y. (2017) · Dyes and Pigments · doi:10.1016/j.dyepig.2017.07.025 · Cited by 22

Deciphering interior polarity of lysosome in live cancer and normal cells using spectral scanning microscopy

Pal, K., Kumar, P., & Koner, A. L. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111848 · Cited by 22

New AIE-active terpyridyl-based pyridinium salt with good water-soluble: Membrane-permeable probe for cellular endoplasmic reticulum imaging

Rao, Q., Yang, M., Liu, G., Zhang, H., Xu, H., Wang, J., Tian, Y., Yu, J., Wang, A., & Zhou, H. (2019) · Dyes and Pigments · doi:10.1016/j.dyepig.2019.04.035 · Cited by 21

A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells

Kim, H. R., Kumar, R., Kim, W., et al. (2016) · Chemical Communications · doi:10.1039/c6cc02330d · Cited by 20

Construction of an efficient two-photon fluorescent probe for imaging nitroreductase in live cells and tissues

Zhou, L., Gong, L., & Hu, S. (2018) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2018.03.073 · Cited by 20

Dual site‐controlled two‐photon fluorescent probe for the imaging of lysosomal pH in living cells

Wang, C., Dong, B., Kong, X., Zhang, N., Song, W., & Lin, W. (2018) · Luminescence · doi:10.1002/bio.3546 · Cited by 20

A benzothiazole-based water soluble and pH-independent probe for nitroreductase with a dramatic change of chromogenic and fluorogenic properties

Na, S., Park, S., Kim, S., & Kim, H.-J. (2018) · Dyes and Pigments · doi:10.1016/j.dyepig.2018.09.053 · Cited by 20

A bright two-photon fluorescent probe for real-time monitoring autophagy in living cells

Jiang, C., Li, L., Jiang, J., Hou, L., Fang, G., Yu, H., & Meng, X. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.07.046 · Cited by 20

Two-Photon Probes for Golgi Apparatus: Detection of Golgi Apparatus in Live Tissue by Two-Photon Microscopy

Choi, J.-W., Hong, S. T., Kim, M. S., Paik, K. C., Han, M. S., & Cho, B. R. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00607 · Cited by 19

BODIPY/Nile‐Red‐Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity

Yang, Z., Wi, Y., Yoon, Y., Verwilst, P., Jang, J. H., Kim, T. W., Kang, C., & Kim, J. S. (2015) · Chemistry - An Asian Journal · doi:10.1002/asia.201501060 · Cited by 18

Visualization of intracellular lipid droplets using lipophilic benzothiazole-based push-pull fluorophores at ultralow concentration

Filho, M. S., Dao, P., Martin, A. R., & Benhida, R. (2019) · Dyes and Pigments · doi:10.1016/j.dyepig.2019.04.003 · Cited by 16

Dynamic cyclic behaviors of lipid droplets monitored by two-photon fluorescence probe with high photostability

Liu, G., Wang, J., Zhang, G., Zhang, H., Zhu, Y., Xu, H., Kong, L., Tian, Y., Zhu, X., & Zhou, H. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117766 · Cited by 14

Coumarin‐based Fluorescent Probes for Selectively Targeting and Imaging the Endoplasmic Reticulum in Mammalian Cells

Wijesooriya, C. S., Nieszala, M., Stafford, A., Zimmerman, J. R., & Smith, E. A. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12985 · Cited by 8

A molecular probe based on pyrimidine imidazole derivatives for stable super-resolution endoplasmic reticulum imaging in living cells

Hu, L., Hussain, S., Liu, T., Yue, Y., Liu, J., Tian, Y., & Tian, X. (2018) · New Journal of Chemistry · doi:10.1039/c8nj03986k · Cited by 6

Synthesis of azonia cyanine derivatives as NIR fluorescent probes for nucleic acid detection and cell imaging

Chen, Y., Wei, X.-R., Sun, R., Xu, Y.-J., & Ge, J. (2019) · Analytical Methods · doi:10.1039/c9ay00982e · Cited by 6

Preparation and application of pH-responsive drug delivery systems

Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.056 · Cited by 645

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341

Advances on fluorescence bioimaging and photo-mediated therapy of NIR-II small molecule dyes

Zhang, W., Laraib, Huo, F., & Yin, C. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216587 · Cited by 26

Multiplex Cellular Microenvironment Detection Based on Surface-Enhanced Raman Scattering Patch

Wu, X., Zhang, Z., Zhu, F., Kuang, Y., Chen, S., Sun, C., Liu, B., & Wang, Y. (2025) · Chemistry–Methods · doi:10.1002/cmtd.202400083