Preparation and application of pH-responsive drug delivery systems

New developments in liposomal drug delivery

Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600 · see citing works

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works

pH-Sensitive nano-systems for drug delivery in cancer therapy

Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121 · see citing works

Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing

Liang, Y., Li, Z., Huang, Y. P., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,091 · see citing works

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004 · see citing works

Tumour acidosis: from the passenger to the driver's seat

Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 998 · see citing works

Ph sensitive hydrogels in drug delivery: brief history, properties, swelling, and release mechanism, material selection and applications

Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844 · see citing works

Mesoporous silica nanoparticles for drug and gene delivery

Zhou, Y., Quan, G., Wu, Q., Zhang, X., Niu, B., Wu, B., Huang, Y., Pan, X., & Wu, C. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.01.007 · Cited by 712 · see citing works

Polymeric Conjugates for Drug Delivery

Larson, N., & Ghandehari, H. (2012) · Chemistry of Materials · doi:10.1021/cm2031569 · Cited by 580 · see citing works

Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions

Yin, J., Huang, L., Wu, L., Li, J., James, T. D., & Lin, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00645b · Cited by 548 · see citing works

Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics

Radovic‐Moreno, A. F., Lu, T. K., Puscasu, V. A., Yoon, S.-S., Langer, R., & Farokhzad, O. C. (2012) · ACS Nano · doi:10.1021/nn3008383 · Cited by 542 · see citing works

A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

Mi, P., Kokuryo, D., Cabral, H., Wu, H., Terada, Y., Saga, T., Aoki, I., Nishiyama, N., & Kataoka, K. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.72 · Cited by 513 · see citing works

Polyphenol-Mediated Assembly for Particle Engineering

Zhou, J., Lin, Z., Ju, Y., Rahim, M. A., Richardson, J. J., & Caruso, F. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00150 · Cited by 503 · see citing works

Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms

Hu, D., Deng, Y., Jia, F., Jin, Q., & Ji, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b05493 · Cited by 490 · see citing works

Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy

Li, J., Rao, J., & Pu, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.025 · Cited by 469 · see citing works

Injectable antibacterial conductive hydrogels with dual response to an electric field and pH for localized “smart” drug release

Qu, J., Zhao, X., Ma, P. X., & Guo, B. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.018 · Cited by 468 · see citing works

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

Aibani, N., Rai, R., Patel, P., Cuddihy, G., & Wasan, E. K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101686 · Cited by 406 · see citing works

Recent advances in dendrimer-based nanovectors for tumor-targeted drug and gene delivery

Kesharwani, P., & Iyer, A. K. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.12.012 · Cited by 382 · see citing works

pH- and ion-sensitive polymers for drug delivery

Yoshida, T., Lai, T. C., Kwon, G. S., & Sako, K. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.821978 · Cited by 367 · see citing works

Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

Wang, Y., Wu, Y., Long, L., Yang, L., Fu, D., Hu, C., Kong, Q., & Wang, Y. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c09889 · Cited by 356 · see citing works

Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis

Lei, Y., Wang, Y., Shen, J., Cai, Z., Zhao, C., Chen, H., Luo, X., Hu, N., Cui, W., & Huang, W. (2022) · Science Advances · doi:10.1126/sciadv.abl6449 · Cited by 346 · see citing works

Facile synthesis of pH-responsive sodium alginate/carboxymethyl chitosan hydrogel beads promoted by hydrogen bond

Jing, H., Huang, X., Du, X., Mo, L., Ma, C., & Wang, H. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118993 · Cited by 321 · see citing works

Nanoparticle-mediated targeted drug delivery for breast cancer treatment

Liyanage, P. Y., Hettiarachchi, S. D., Zhou, Y., Ouhtit, A., Seven, E. S., Oztan, C. Y., Çelik, E., & Leblanc, R. M. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.006 · Cited by 287 · see citing works

Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

Zhao, Z., Wang, Z., Li, G., Cai, Z., Wu, J., Wang, L., Deng, L., Cai, M., & Cui, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103339 · Cited by 282 · see citing works

Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer

Zhang, Y., Yang, C., Wang, W., Liu, J., Liu, Q., Huang, F., Chu, L., Gao, H., Liu, Q., Kong, D., et al. (2016) · Scientific Reports · doi:10.1038/srep21225 · Cited by 273 · see citing works

Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review

Wang, Z., Deng, X., Ding, J., Zhou, W., Zheng, X., & Tang, G. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.003 · Cited by 271 · see citing works

New Advances in General Biomedical Applications of PAMAM Dendrimers

de Araújo, R. V., Santos, S. D. S., Ferreira, E. I., & Giarolla, J. (2018) · Molecules · doi:10.3390/molecules23112849 · Cited by 269 · see citing works

Hyaluronic acid and albumin based nanoparticles for drug delivery

Lei, C., Liu, X.-R., Chen, Q., Li, Y., Zhou, J., Zhou, L.-Y., & Zou, T. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.033 · Cited by 267 · see citing works

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Cook, A. B., & Decuzzi, P. (2021) · ACS Nano · doi:10.1021/acsnano.0c09115 · Cited by 266 · see citing works

Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation

Ruan, S., Hu, C., Tang, X., Cun, X., Xiao, W., Shi, K., He, Q., & Gao, H. (2016) · ACS Nano · doi:10.1021/acsnano.6b05070 · Cited by 263 · see citing works

Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Liput, K. P., Lepczyński, A., Ogłuszka, M., Nawrocka, A., Poławska, E., Grzesiak, A., Ślaska, B., Pareek, C. S., Czarnik, U., & Pierzchała, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136965 · Cited by 256 · see citing works

Facile Access to Multisensitive and Self-Healing Hydrogels with Reversible and Dynamic Boronic Ester and Disulfide Linkages

Guo, R., Su, Q., Zhang, J., Dong, A., Lin, C., & Zhang, J. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00089 · Cited by 254 · see citing works

pH-sensitive biomaterials for drug delivery

Zhuo, S., Zhang, F., Yu, J., Zhang, X., Yang, G., & Liu, X. (2020) · Molecules · doi:10.3390/molecules25235649 · Cited by 247 · see citing works

Biofilm‐Sensitive Photodynamic Nanoparticles for Enhanced Penetration and Antibacterial Efficiency

Wu, S., Chen, X., Zhu, Y., Zheng, L., Zhang, L., Hu, Y., Yu, B., Wang, Y., & Xu, F. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103591 · Cited by 243 · see citing works

Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

Sadhukhan, P., Kundu, M., Chatterjee, S., Ghosh, N., Manna, P., Das, J., & Sil, P. C. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.02.096 · Cited by 226 · see citing works

Macromolecular metamorphosis via stimulus-induced transformations of polymer architecture

Sun, H., Kabb, C. P., Dai, Y., Hill, M. R., Ghiviriga, I., Bapat, A. P., & Sumerlin, B. S. (2017) · Nature Chemistry · doi:10.1038/nchem.2730 · Cited by 220 · see citing works

Imaging small molecule-induced endosomal escape of siRNA

Rietz, H. D., Hedlund, H., Wilhelmson, S., Nordenfelt, P., & Wittrup, A. (2020) · Nature Communications · doi:10.1038/s41467-020-15300-1 · Cited by 203 · see citing works

Injectable and Self-Healing Nanocomposite Hydrogels with Ultrasensitive pH-Responsiveness and Tunable Mechanical Properties: Implications for Controlled Drug Delivery

Wu, M. Y., Chen, J., Huang, W., Yan, B., Peng, Q., Liu, J., Chen, L., & Zeng, H. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00347 · Cited by 201 · see citing works

Biologically derived metal organic frameworks

Anderson, S. L., & Stylianou, K. C. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.07.012 · Cited by 197 · see citing works

Paclitaxel-loaded pH responsive hydrogel based on self-assembled peptides for tumor targeting

Raza, F., Zhu, Y., Chen, L., You, X., Zhang, J., Asifullah, K., Khan, M. W., Hasnat, M., Zafar, H., Wu, J., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm00139e · Cited by 194 · see citing works

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Jiang, L., Zhou, S., Zhang, X., Li, C., Ji, S., Mao, H. Z., & Jiang, X. (2021) · Nature Communications · doi:10.1038/s41467-021-22594-2 · Cited by 192 · see citing works

pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy

Shi, Z., Li, Q., & Mei, L. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.001 · Cited by 188 · see citing works

pH-Sensitive nanogels for drug delivery in cancer therapy

Li, Z., Huang, J. C., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01729a · Cited by 186 · see citing works

PEG- b -PCL Copolymer Micelles with the Ability of pH-Controlled Negative-to-Positive Charge Reversal for Intracellular Delivery of Doxorubicin

Deng, H., Liu, J., Zhao, X., Zhang, Y., Liu, J., Xu, S., Deng, L., Dong, A., & Zhang, J. (2014) · Biomacromolecules · doi:10.1021/bm501290t · Cited by 185 · see citing works

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

Khiev, D., Mohamed, Z. A., Vichare, R., Paulson, R. J., Bhatia, S., Mohapatra, S., Lobo, G. P., Valapala, M., Kerur, N., Passaglia, C. L., et al. (2021) · Nanomaterials · doi:10.3390/nano11010173 · Cited by 182 · see citing works

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Ramírez-García, P. D., Retamal, J. S., Shenoy, P. A., Imlach, W. L., Sykes, M., Truong, N. P., Constandil, L., Pélissier, T., Nowell, C. J., Khor, S. Y., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0568-x · Cited by 161 · see citing works

NMR Insights into Dendrimer-Based Host–Guest Systems

Hu, J., Xu, T., & Cheng, Y. (2012) · Chemical Reviews · doi:10.1021/cr200333h · Cited by 160 · see citing works

Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin

Kim, A. R., Lee, S. L., & Park, S. N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.06.061 · Cited by 159 · see citing works

Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin

Qiu, L., Qiao, M., Chen, Q., Tian, C., Long, M., Wang, M., Li, Z., Hu, W. S., Li, G., Cheng, L., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.008 · Cited by 153 · see citing works

Facile preparation of pH-sensitive chitosan microspheres for delivery of curcumin; characterization, drug release kinetics and evaluation of anticancer activity

Pooresmaeil, M., & Namazi, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.183 · Cited by 153 · see citing works

Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release

Gu, Z., Dong, Y., Xu, S., Wang, L., & Liu, Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202012956 · Cited by 147 · see citing works

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

Luo, L., Qi, Y., Zhong, H., Jiang, S., Zhang, H., Cai, H., Wu, Y., Gu, Z., Gong, Q., & Luo, K. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.05.003 · Cited by 143 · see citing works

pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury

Zhang, C. Y., Lin, W., Gao, J., Shi, X., Davaritouchaee, M., Nielsen, A. E., Mancini, R. J., & Wang, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b04051 · Cited by 142 · see citing works

A pH/ROS dual-responsive and targeting nanotherapy for vascular inflammatory diseases

Zhang, R., Liu, R., Liu, C., Pan, L., Qi, Y., Cheng, J., Guo, J., Jia, Y., Ding, J., Zhang, J., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119605 · Cited by 142 · see citing works

Acetal containing polymers as pH-responsive nano-drug delivery systems

Gannimani, R., Walvekar, P., Naidu, V. R., Aminabhavi, T. M., & Govender, T. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.044 · Cited by 142 · see citing works

A transistor-like pH-sensitive nanodetergent for selective cancer therapy

Liu, M., Huang, L., Zhang, W., Wang, X., Geng, Y., Zhang, Y., Wang, L., Zhang, W., Zhang, Y., Xiao, S., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01085-5 · Cited by 140 · see citing works

Graphene quantum dot cross-linked carboxymethyl cellulose nanocomposite hydrogel for pH-sensitive oral anticancer drug delivery with potential bioimaging properties

Rakhshaei, R., Namazi, H., Hamishehkar, H., & Rahimi, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.118 · Cited by 136 · see citing works

pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma

Ling, D., Xia, H., Park, W., Hackett, M., Song, C., Na, K., Hui, K. M., & Hyeon, T. (2014) · ACS Nano · doi:10.1021/nn502074x · Cited by 135 · see citing works

Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma

Zhang, C., An, T., Wang, D., Wan, G., Zhang, M., Wang, H., Zhang, S., Li, R., Yang, X., & Wang, Y. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.030 · Cited by 133 · see citing works

Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

Zhang, M., Zhu, J., Zheng, Y. F., Guo, R., Wang, S., Mignani, S. M., Caminade, A., Majoral, J., & Shi, X. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030162 · Cited by 129 · see citing works

pH-responsive cationic liposome for endosomal escape mediated drug delivery

Rayamajhi, S., Marchitto, J., Nguyen, T. D. T., Marasini, R., Celia, C., & Aryal, S. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110804 · Cited by 125 · see citing works

Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF

Xu, R. F., Yang, J., Qian, Y., Deng, H., Wang, Z., Ma, S., Wei, Y., Yang, N., & Shen, Q. (2021) · Nanoscale Horizons · doi:10.1039/d0nh00674b · Cited by 125 · see citing works

Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia

Li, Z., Clemens, D. L., Lee, B., Dillon, B. J., Horwitz, M. A., & Zink, J. I. (2015) · ACS Nano · doi:10.1021/acsnano.5b04306 · Cited by 123 · see citing works

Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer

Hou, Y., Jin, J., Duan, H., Liu, C., Chen, L., Huang, W., Gao, Z., & Jin, M. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121440 · Cited by 123 · see citing works

Incorporating Cu-based metal-organic framework/drug nanohybrids into gelatin microsphere for ibuprofen oral delivery

Javanbakht, S., Nezhad‐Mokhtari, P., Shaabani, A., Arsalani, N., & Ghorbani, M. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.11.028 · Cited by 122 · see citing works

Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

Tao, W., Wang, J., Parak, W. J., Farokhzad, O. C., & Shi, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b01696 · Cited by 119 · see citing works

Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker

Omidi, S., Pirhayati, M., & Kakanejadifard, A. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115745 · Cited by 118 · see citing works

Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment

Li, J., & Burgess, D. J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.05.008 · Cited by 118 · see citing works

Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

Xie, J., Gonzalez‐Carter, D., Tockary, T. A., Nakamura, N., Xue, Y., Nakakido, M., Akiba, H., Dirisala, A., Liu, X., Toh, K., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b09991 · Cited by 116 · see citing works

Mineralization of pH-Sensitive Doxorubicin Prodrug in ZIF-8 to Enable Targeted Delivery to Solid Tumors

Yan, J., Liu, C., Wu, Q., Zhou, J., Xu, X., Zhang, L., Wang, D., Yang, F., & Zhang, H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02599 · Cited by 116 · see citing works

Dimeric prodrug-based nanomedicines for cancer therapy

Li, S., Shan, X., Wang, Y., Chen, Q., Sun, J., He, Z., Sun, B., & Luo, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.036 · Cited by 116 · see citing works

ZnO-Based Nanoplatforms for Labeling and Treatment of Mouse Tumors without Detectable Toxic Side Effects

Ye, D.-X., Ma, Y., Zhao, W., Cao, H., Kong, J., Xiong, H., & Möhwald, H. (2016) · ACS Nano · doi:10.1021/acsnano.5b07846 · Cited by 115 · see citing works

Dendrimer-Au Nanoparticle Network Covered Alumina Membrane for Ion Rectification and Enhanced Bioanalysis

Wang, C., Zhao, X., Liu, F., Chen, Y., Xia, X., & Li, J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b05066 · Cited by 115 · see citing works

An update on actively targeted liposomes in advanced drug delivery to glioma

Mojarad-Jabali, S., Farshbaf, M., Walker, P. R., Hemmati, S., Fatahi, Y., Zakeri‐Milani, P., Sarfraz, M., & Valizadeh, H. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120645 · Cited by 115 · see citing works

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment – Synergistic effect of thrombolysis and antioxidant –

Mei, T., Kim, A., Vong, L. B., Marushima, A., Puentes, S., Matsumaru, Y., Matsumura, A., & Nagasaki, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.05.020 · Cited by 114 · see citing works

Stimuli-responsive polymeric prodrug-based nanomedicine delivering nifuroxazide and doxorubicin against primary breast cancer and pulmonary metastasis

Luo, L., Xu, F., Peng, H., Luo, Y., Tian, X., Battaglia, G., Zhang, H., Gong, Q., Gu, Z., & Luo, K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.017 · Cited by 113 · see citing works

Advances in pH‐Sensitive Polymers for Smart Insulin Delivery

Xie, J., Li, A., & Li, J. (2017) · Macromolecular Rapid Communications · doi:10.1002/marc.201700413 · Cited by 108 · see citing works

A natural drug entry channel in the ferritin nanocage

Jiang, B., Chen, X., Sun, G., Chen, X., Yin, Y., Jin, Y., Mi, Q., Ma, L., Yang, Y., Yan, X., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100948 · Cited by 108 · see citing works

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Mou, J., Liu, Z., Liu, J., Lu, J., Zhu, W.-T., & Pei, D. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1571121 · Cited by 106 · see citing works

Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment

He, W., Mei, Q., Li, J., Zhai, Y., Chen, Y., Wang, R., Lu, E., Zhang, X., Zhang, Z., & Sha, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00231 · Cited by 106 · see citing works

A pH‐Mediated Electronic Wound Dressing for Controlled Drug Delivery

Kiaee, G., Mostafalu, P., Samandari, M., & Sonkusale, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800396 · Cited by 105 · see citing works

Non-small cell lung cancer combination therapy: Hyaluronic acid modified, epidermal growth factor receptor targeted, pH sensitive lipid-polymer hybrid nanoparticles for the delivery of erlotinib plus bevacizumab

Pang, J., Xing, H., Sun, Y., Feng, S., & Wang, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109861 · Cited by 105 · see citing works

Construction of an environmentally friendly octenylsuccinic anhydride modified pH-sensitive chitosan nanoparticle drug delivery system to alleviate inflammation and oxidative stress

Yu, Z., Ma, L., Ye, S., Li, G., & Zhang, M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115972 · Cited by 104 · see citing works

Self-healable hydrogel on tumor cell as drug delivery system for localized and effective therapy

Chang, G., Chen, Y., Li, Y., Li, S., Huang, F., Shen, Y., & Xie, A. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.12.077 · Cited by 100 · see citing works

pH and thermal dual-responsive poly(NIPAM-co-GMA)-coated magnetic nanoparticles via surface-initiated RAFT polymerization for controlled drug delivery

Pourjavadi, A., Kohestanian, M., & Streb, C. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110418 · Cited by 100 · see citing works

pH-Responsive nanoparticles based on cholesterol/imidazole modified oxidized-starch for targeted anticancer drug delivery

Xu, Y., Zi, Y., Lei, J., Mo, X., Shao, Z., Wu, Y., Tian, Y., Li, D., & Mu, C. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115858 · Cited by 100 · see citing works

Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

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pH-Sensitive carboxymethyl chitosan-modified cationic liposomes for sorafenib and siRNA co-delivery

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DOX-Conjugated keratin nanoparticles for pH-Sensitive drug delivery

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Pharmacological mechanisms and drug delivery systems of ginsenoside Rg3: A comprehensive review

Yao, Z.-W., & Zhu, H. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107799 · Cited by 44 · see citing works

Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy

Zhang, Y., Zhou, J., Chen, X., Li, Z., Gu, L., Pan, D., Zheng, X., Zhang, Q., Chen, R., Zhang, H., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.015 · Cited by 43 · see citing works

Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Zhang, J., Zhou, J., Tang, L., Ma, J., Wang, Y., Yang, H. Y., Wang, X., & Fan, W. (2024) · Small · doi:10.1002/smll.202400353 · Cited by 45 · see citing works

pH-responsive polymeric nanomaterials for the treatment of oral biofilm infections

Jeong, G., Rather, M. A., Khan, F., Tabassum, N., Mandal, M., & Kim, Y. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113727 · Cited by 42 · see citing works

Research progress in nano-drug delivery systems based on the characteristics of the liver cancer microenvironment

Lu, S., Zhang, C., Wang, J., Zhao, L., & Li, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116059 · Cited by 42 · see citing works

Recent advances in injectable hydrogel therapies for periodontitis

Ran, S., Xue, L., Wei, X., Huang, J., Yan, X., He, T., Tang, Z., Zhang, H., & Gu, M. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb03070a · Cited by 42 · see citing works

A review of pH-responsive chitosan-based hydrogels for drug delivery applications

Rodríguez‐Rodríguez, R., Carreón‐Álvarez, C., Cruz-Medina, C. A., Knauth, P., López, Z., Fletes-Vargas, G., & Sahagún, M. R. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.114173 · Cited by 42 · see citing works

Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy

Li, S., Mok, G. S. P., & Dai, Y. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115110 · Cited by 41 · see citing works

Design and development of pH-responsive alginate-based nanogel carriers for etoposide delivery

Geyik, G., Güncüm, E., & Işıklan, N. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126242 · Cited by 40 · see citing works

Enzyme‐Responsive Branched Glycopolymer‐Based Nanoassembly for Co‐Delivery of Paclitaxel and Akt Inhibitor toward Synergistic Therapy of Gastric Cancer

Song, X., Cai, H., Shi, Z.-C., Li, Z., Zheng, X., Yang, K.-H., Gong, Q.-Y., Gu, Z., Hu, J.-K., & Luo, K. (2023) · Advancement of science · doi:10.1002/advs.202306230 · Cited by 37 · see citing works

Advancements in chitosan-based nanocomposites with ZIF-8 nanoparticles: multifunctional platforms for wound healing applications

Tarin, M., Oryani, M. A., Javid, H., Hashemzadeh, A., & Karimi‐Shahri, M. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123656 · Cited by 40 · see citing works

NO-releasing double-crosslinked responsive hydrogels accelerate the treatment and repair of ischemic stroke

Guo, W. P., Hu, C., Wang, Y., Zhang, W., Zhang, S., Peng, J., Wang, Y., & Wu, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.01.005 · Cited by 39 · see citing works

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi, S. R., Wang, Y., Ashaolu, T. J., Sharma, M., Rawal, S. U., Patel, K., Askari, G., Javanmard, S. H., & Rostamabadi, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202209419 · Cited by 38 · see citing works

Machine Learning‐Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug–Drug Self‐Assembly

Zhang, C., Yuan, Y., Xia, Q., Wang, J., Xu, K., Gong, Z., Lou, J., Li, G., Wang, L., Zhou, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202415902 · Cited by 38 · see citing works

Multifunctional hydrogel for synergistic reoxygenation and chemo/photothermal therapy in metastatic breast cancer recurrence and wound infection

Chen, J., Zhang, X., Zhang, J., Wang, Z., Zhu, G., Geng, M., Zhu, J., Chen, Y., Wang, W., & Xu, Y. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.11.024 · Cited by 37 · see citing works

Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer

Zhang, J., Ali, K., & Wang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s466490 · Cited by 38 · see citing works

Engineering therapeutic scaffolds: integrating drug delivery with tissue regeneration

Moghaddam, M. M., Aghajanzadeh, M. S., & Imani, R. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01338k · Cited by 37 · see citing works

Antiviral drug discovery and development: challenges and future directions

Du, S., Hu, X., Li, P., Xu, S., Kim, M., Liu, X., & Zhan, P. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02539-7 · Cited by 37 · see citing works

Exploration of Ultrasound‐Sensitive Biomaterials in Cancer Theranostics

Yang, Y., Liang, H., Tang, C. Y., Cheng, Y., & Cheng, L. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202313454 · Cited by 36 · see citing works

Stimuli‐Responsive Nanocarriers for Transcytosis‐Based Cancer Drug Delivery

Wang, Z., Sun, Y., Shen, Y., & Zhou, Z. (2024) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300125 · Cited by 36 · see citing works

Self-healing and injectable chitosan/konjac glucomannan hydrogel with pH response for controlled protein release

Lin, C. X., Yang, K., Li, P. C., Gao, L. T., Aziz, Y., Li, J. H., Miyatake, H., Ito, Y., & Chen, Y. M. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114089 · Cited by 36 · see citing works

Overcoming Biopotency Barriers: Advanced Oral Delivery Strategies for Enhancing the Efficacy of Bioactive Food Ingredients

Liu, L., McClements, D. J., Liu, X., & Liu, F. (2024) · Advanced Science · doi:10.1002/advs.202401172 · Cited by 39 · see citing works

pH-Responsive Metal–Organic Framework Thin Film for Drug Delivery

Guillen, S. G., Parres-Gold, J., Ruiz, A., Lucsik, E., Dao, B., Hang, T. K. L., Chang, M., Garcia, A., Wang, Y., & Tian, F. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c02497 · Cited by 35 · see citing works

Multifunctional hydrogels: advanced therapeutic tools for osteochondral regeneration

Zhang, W., Zha, K., Hu, W., Xiong, Y., Knoedler, S. A., Obed, D., Panayi, A. C., Lin, Z., Cao, F., Mi, B., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00411-9 · Cited by 37 · see citing works

Tumor‐Targeted Catalytic Immunotherapy

Yang, E., Wang, W., Liu, Y., Yi, H., Lei, A., & Sun, Z. (2024) · Advanced Materials · doi:10.1002/adma.202413210 · Cited by 35 · see citing works

Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy

Xu, Z., Liu, J., Hu, H., Ma, J., Yang, H., Chen, J., Xu, H., Hu, H., Luo, H., & Chen, G. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1539566 · Cited by 35 · see citing works

Surfactant-Enabled Nanocarriers in Breast Cancer Therapy: Targeted Delivery and Multidrug Resistance Reversal

Jadhav, A., & Nagaraj, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060779 · Cited by 35 · see citing works

Targeted drug delivery systems for elemene in cancer therapy: The story thus far

Tian, H., Zhao, F., Qi, Q.-R., Yue, B., & Zhai, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115331 · Cited by 35 · see citing works

Acid-sensitive prodrugs; a promising approach for site-specific and targeted drug release

Nazli, A., Khan, M. Z. I., Rácz, Á., & Béni, S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116699 · Cited by 34 · see citing works

Poly(lactic-co-glycolic acid) nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment

Ding, Q., Luo, Y., Wu, H., Tao, J., Zhang, Y., Yin, G., Qian, K., Chen, Y., Mei, L., Cheng, Z., et al. (2025) · Science China Chemistry · doi:10.1007/s11426-025-2889-2 · Cited by 34 · see citing works

Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms

Cheng, G., Xie, A., Yan, Z., Zhu, X., Song, Y., & Chen, T. (2023) · Brain‐X · doi:10.1002/brx2.27 · Cited by 34 · see citing works

Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review

Liu, Y., Zhao, Z., Guo, C. F., Huang, Z., Zhang, W., Ma, F., Wang, Z., Kong, Q., & Wang, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1286223 · Cited by 33 · see citing works

Advancements in Stimulus-Responsive Co-Delivery Nanocarriers for Enhanced Cancer Immunotherapy

Zhang, M.-R., Fang, L., Guo, Y., Wang, Q., Li, Y., Sun, H., Xie, S., & Liang, Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s454004 · Cited by 33 · see citing works

Next-Generation Drug Delivery for Neurotherapeutics: The Promise of Stimuli-Triggered Nanocarriers

Boyuklieva, R., Zahariev, N., Simeonov, P., Penkov, D., & Katsarov, P. (2025) · Biomedicines · doi:10.3390/biomedicines13061464 · Cited by 33 · see citing works

Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery

Othman, R. S., Zarei, S., Haghighat, H. R., Taromi, A. A., & Khonakdar, H. A. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70180 · Cited by 32 · see citing works

Advances in nanocarrier-mediated cancer therapy: Progress in immunotherapy, chemotherapy, and radiotherapy

Yue, P., Yu, M., Li, B., Zhang, S., Cheng, J., Wu, F., Du, S., Miao, J., Hu, B., Olkhovsky, I. A., et al. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003703 · Cited by 32 · see citing works

A review on polysaccharide-based delivery systems for edible bioactives: pH responsive, controlled release, and emerging applications

Guo, J., Qiu, Y., Zhang, J., Xue, C., & Zhu, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139178 · Cited by 31 · see citing works

Disulfidptosis Nanoinducer Interrupts Tumor Metabolic Privilege to Boost Sustained Immunotherapy

Xu, Y., Ming, X., Qi, J., Huang, Z., Zhu, H., Wu, M., Feng, S., & Wan, Y. (2025) · ACS Nano · doi:10.1021/acsnano.5c08432 · Cited by 31 · see citing works

Smart Nanoarchitectures for Precision RNA Delivery: Harnessing Endogenous and Exogenous Stimuli in Cancer Treatment

Hao, J., Li, Y., Huang, L., Qi, N., Sun, Y., He, C., Yang, S., Niu, Z.-Y., Qi, X., & Xiang, B. (2025) · Theranostics · doi:10.7150/thno.112492 · Cited by 32 · see citing works

Reversible Chemistry for Cancer Therapy and Diagnosis

Xu, H., Hong, H., Kim, C., Lee, Y., Li, Y., Zhang, Y. S., Makvandi, P., Song, G., Zhang, H., Kang, H., et al. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00549 · Cited by 31 · see citing works

Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

Shukla, M. K., Parihar, A., Karthikeyan, C., Kumar, D., & Khan, R. (2023) · Nanoscale · doi:10.1039/d3nr03161f · Cited by 30 · see citing works

pH-Responsive Micro/Nano Drug Delivery

Nouri, B., Montazer, M., & Malek, R. M. A. (2024) · CRC Press eBooks · doi:10.1201/9781003468424-15

pH-sensitive drug delivery systems

Ghaffar, A., Yameen, B., Latif, M., & Malik, M. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816960-5.00014-8 · Cited by 23 · see citing works

Ph-responsive drug delivery systems as intelligent carriers for targeted drug therapy: brief history, properties, synthesis, mechanism and application

Bami, M. S., Raeisi Estabragh, M. A., Khazaeli, P., Ohadi, M., & Dehghannoudeh, G. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102987 · Cited by 101 · see citing works

Microenvironment-Activated Smart Drug Delivery System: An Integrated Review of pH-Responsive Polymers, Nanocarriers and Dual-Stimuli Innovation

Vanitha S*, B. A. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.20839250

pH-Sensitive Nanomaterials for Smart Release of Drugs

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