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Cited by 16Analytical chemistry methods developmentForensic Toxicology and Drug AnalysisMass Spectrometry Techniques and Applications

Polydopamine coated hypodermic needles as a microextraction device for the determination of tricyclic antidepressants in oral fluid by direct infusion MS/MS

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Vejar-Vivar, Carmina, García-Valverde, María Teresa, Mardones, Claudia, Lucena, Rafael, Cárdenas, Soledad·2021·RSC Advances
DOI 10.1039/d1ra02721bPMC PMC9034363
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Abstract

for all analytes. The precision, expressed as relative standard deviation (RSD), is better than 10% for all analytes. Accuracy was calculated as recovery, and the obtained values are between 84% and 107%. A single-blind assay was also performed to evaluate the suitability of the method for real application.

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  • When integrated with disposable microfluidic chambers, the PDA-modified screen-printed carbon electrode platform enables on-site quantification of bacterial load.

    “When integrated with disposable microfluidic chambers, this platform enables on-site quantification of bacterial load.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [93]

    The Introduction and Experimental ‘Microextraction procedure’ (page not provided) identify the platform as polydopamine-coated hypodermic needles attached to a syringe or micropipette, not screen-printed carbon electrodes integrated with microfluidic chambers. The Conclusion says it extracts tricyclic antidepressants from oral fluid for mass-spectrometric analysis, rather than quantifying bacterial load on site. (LLM, conf=0.88)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured

  • Urease and glucose oxidase co-immobilized on the sensing interface allow simultaneous acquisition of urea hydrolysis rates and lactic acid production rates by differential potentiometry.

    “In parallel, urease and glucose oxidase are co-immobilized on the sensing interface, allowing simultaneous acquisition of urea hydrolysis rates and lactic acid production rates by differential potentiometry.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [93]

    The Experimental section (Direct infusion MS analysis; page not provided) describes mass-spectrometric detection, while Results and discussion (Method validation; page not provided) concerns tricyclic antidepressants in oral fluid. Searches for urease and glucose oxidase co-immobilization, urea hydrolysis, lactic acid production, and differential potentiometry found no passage addressing the claim. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • Based on these measurements, the time required for the local pH to reach the critical threshold of 5.5 can be estimated, providing quantitative support for individualized caries risk assessment and personalized fluoride intervention strategies.

    “Based on these measurements, the time required for the local pH to reach the critical threshold of 5.5 can be estimated, thereby providing quantitative support for individualized caries risk assessment and personalized fluoride intervention strategies.44,93,94”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [93]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.

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References 54 · Cited by 16

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Authors
Vejar-Vivar, C., García-Valverde, M. T., Mardones, C., Lucena, R., & Cárdenas, S.
Affiliations
  • Universidad de Córdoba (CO)
  • University of Concepción (CL)
Corresponding author
Lucena, Rafael
ORCID
Venue
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Published
2021
Volume
11
Issue
37
Pages
22683-22690
ISSN
2046-2069 (ISSN-L)
DOI
10.1039/d1ra02721b
PMC
PMC9034363
OpenAlex
W3175852265
Cited by
16
References
54
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 1
FWCI
1.63
Type
journal article
Language
en
Open access
Licence
Locations
  • RSC Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Ministerio de Economía y Competitividad (CTQ2017-83175R)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Keywords
polydopamine coating, hypodermic needle, microextraction, tricyclic antidepressants, oral fluid, drug monitoring

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