A pH-sensitive T7 peptide-decorated liposome system for HER2 inhibitor extracellular delivery: an application for the efficient suppression of HER2+ breast cancer
Abstract
An in vivo active-targeted transportation of T7-LP@LAP and acid-triggered drug release on the outer surface of HER2+ breast cancer cells.
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T7-modified liposomes actively target breast cancer tumors and reduce toxicity to normal tissues.
“Zhang et al. used T7 peptide modified liposomes as a carrier for transporting HER2 inhibitors, which can actively target breast cancer tumors and reduce the toxicity to normal tissues.227”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [227]
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- Authors
- Zhang, S., Sun, Q., Peng, X., Gan, N., Zhao, L., Suo, Z., Zhao, G., & Li, H.
- Affiliations
- Sichuan University (CN)
- Laboratory Animal Center, Sichuan University, Chengdu 610065, Sichuan, China
- Corresponding author
- Sun, Qiaomei
- Zhao, Gang
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 9
- Issue
- 42
- Pages
- 8768-8778
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W3198934794
- Cited by
- 16
- References
- 38
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 2 · 2022: 4
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities (2018SCU12043)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- HER2-positive breast cancer, lapatinib, T7 peptide, pH-sensitive liposomes, targeted drug delivery, sustained drug release, tumor acidosis, nanoparticle drug delivery, HER2 inhibitors
- MeSH terms
- Lapatinib, Animals, Antineoplastic Agents, Breast Neoplasms, Cells, Cultured, Drug Screening Assays, Antitumor, Female, Humans, Liposomes, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Mice, Nude, Peptide Fragments, Molecular Structure, Rats, Sprague-Dawley, Erb-b2 Receptor Tyrosine Kinases, Collagen Type IV, Protein Kinase Inhibitors, Cell Proliferation, Mice, Rats, Optical Imaging
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