Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Segmented cell analyses to measure redox states of autofluorescent NAD(P)H, FAD & Trp in cancer cells by FLIM

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γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging

Obara, R., Kamiya, M., Tanaka, Y., Abe, A., Kojima, R., Kawaguchi, T., Sugawara, M., Takahashi, A., Noda, T., & Urano, Y. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202013265 · Cited by 120

Oxidative deoximation reaction induced recognition of hypochlorite based on a new fluorescent lanthanide-organic framework

Zhou, Z., Li, X., Tang, Y., Zhang, C. C., Fu, H., Wu, N., Ma, L., Gao, J., & Wang, Q. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.06.123 · Cited by 119

Evaluating Drug-Induced Liver Injury and Its Remission via Discrimination and Imaging of HClO and H2S with a Two-Photon Fluorescent Probe

Jiao, X., Xiao, Y., Li, Y., Liang, M., Xie, X., Wang, X., & Tang, B. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01106 · Cited by 118

Upconversion Luminescent Chemodosimeter Based on NIR Organic Dye for Monitoring Methylmercury In Vivo

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Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis

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A two-photon NIR-to-NIR fluorescent probe for imaging hydrogen peroxide in living cells

Li, H., Yao, Q., Fan, J., Du, J., Wang, J., & Peng, X. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.03.039 · Cited by 116

A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing

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Recent progress in small molecule fluorescent probes for nitroreductase

Qin, W., Xu, C., Zhao, Y., Yu, C., Shen, S., Li, L., & Huang, W. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.04.007 · Cited by 113

A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

Lee, E., Li, X., Oh, J., Kwon, N., Kim, G., Kim, D., & Yoon, J. (2020) · Chemical Science · doi:10.1039/d0sc01351j · Cited by 113

Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca 2+ -activated K + channels and smooth muscle Ca 2+ sparks

Jackson‐Weaver, O., Osmond, J. M., Riddle, M. A., Naik, J. S., Bosc, L. V. G., Walker, B. R., & Kanagy, N. L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00506.2012 · Cited by 112

New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells

Yapici, N., Jockusch, S., Moscatelli, A., Mandalapu, S. R., Itagaki, Y., Bates, D. K., Wiseman, S. L., Gibson, K. M., Turro, N. J., & Bi, L. (2011) · Organic Letters · doi:10.1021/ol202816m · Cited by 112

A Self‐Transformable pH‐Driven Membrane‐Anchoring Photosensitizer for Effective Photodynamic Therapy to Inhibit Tumor Growth and Metastasis

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Astroglia-Derived ATP Modulates CNS Neuronal Circuits

Illés, P., Burnstock, G., & Tang, Y. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.006 · Cited by 110

Imaging γ-Glutamyltranspeptidase for tumor identification and resection guidance via enzyme-triggered fluorescent probe

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Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

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Atp7b −/− mice as a model for studies of Wilson's disease

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Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer

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Development of a novel anti-tumor theranostic platform: a near-infrared molecular upconversion sensitizer for deep-seated cancer photodynamic therapy

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Quantification of hydroxyl radicals in photocatalysis and acoustic cavitation: Utility of coumarin as a chemical probe

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Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine

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Engineering a Reversible Fluorescent Probe for Real-Time Live-Cell Imaging and Quantification of Mitochondrial ATP

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An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging

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Small-molecule fluorogenic probes for mitochondrial nanoscale imaging

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A H-bond strategy to develop acid-resistant photoswitchable rhodamine spirolactams for super-resolution single-molecule localization microscopy

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A new rhodamine derivative bearing benzothiazole and thiocarbonyl moieties as a highly selective fluorescent and colorimetric chemodosimeter for Hg2+

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Enhancing the ROS generation ability of a rhodamine-decorated iridium( iii ) complex by ligand regulation for endoplasmic reticulum-targeted photodynamic therapy

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A multifunctional heptamethine near-infrared dye for cancer theranosis

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Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy

Liu, C., Zhou, L., Wei, F., Li, L., Zhao, S., Gong, P., Cai, L., & Wong, K. M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b20224 · Cited by 97

Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine

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Bioluminescence-Activated Deep-Tissue Photodynamic Therapy of Cancer

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Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases

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Dual‐Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic‐Chemodynamic Therapy

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Platinum(II)–Gadolinium(III) Complexes as Potential Single‐Molecular Theranostic Agents for Cancer Treatment

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An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells

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Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation

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Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy

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Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer’s disease

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A Mitochondria-Targeted and Viscosity-Sensitive Near-Infrared Fluorescent Probe for Visualization of Fatty Liver, Inflammation and Photodynamic Cancer Therapy

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Simultaneous Sensing of H2S and ATP with a Two-Photon Fluorescent Probe in Alzheimer’s Disease: toward Understanding Why H2S Regulates Glutamate-Induced ATP Dysregulation

Sun, P., Chen, H., Lu, S., Hai, J., Guo, W., Jing, Y., & Wang, B. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01850 · Cited by 90

Activation of apoptosis by rationally constructing NIR amphiphilic AIEgens: surmounting the shackle of mitochondrial membrane potential for amplified tumor ablation

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Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

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One probe for multiple targets: A NIR fluorescent rhodamine-based probe for ONOO− and lysosomal pH detection in live cells

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Resolving subcellular pH with a quantitative fluorescent lifetime biosensor

Rennick, J. J., Nowell, C. J., Pouton, C. W., & Johnston, A. P. R. (2022) · Nature Communications · doi:10.1038/s41467-022-33348-z · Cited by 85

An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide

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Highly Stable and Multifunctional Aza-BODIPY-Based Phototherapeutic Agent for Anticancer Treatment

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A Small‐Molecule Fluorescence Probe for Nuclear ATP

Tamima, U., Sarkar, S., Islam, M. R., Shil, A., Kim, K. H., Reo, Y. J., Jun, Y. W., Banna, H., Lee, S., & Ahn, K. H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202300580 · Cited by 84

A Single Fluorescent pH Probe for Simultaneous Two-Color Visualization of Nuclei and Mitochondria and Monitoring Cell Apoptosis

Yang, R., He, X., Niu, G., Meng, F., Lu, Q., Liu, Z., & Yu, X. (2021) · ACS Sensors · doi:10.1021/acssensors.0c02372 · Cited by 83

Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

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Development of Polyene-Bridged Hybrid Rhodamine Fluorophores for High-Resolution NIR-II Imaging

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Development of an Activity‐Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase‐α in Brain

Baggelaar, M. P., Janssen, F. J., van Esbroeck, A. C. M., den Dulk, H., Allarà, M., Hoogendoorn, S., McGuire, R., Florea, B. I., Meeuwenoord, N. J., van den Elst, H., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306295 · Cited by 79

A Photosensitizer Discretely Loaded Nanoaggregate with Robust Photodynamic Effect for Local Treatment Triggers Systemic Antitumor Responses

Zhao, H., Xu, J., Wang, Y., Sun, C., Bao, L., Zhao, Y., Yang, X., & Zhao, Y. (2022) · ACS Nano · doi:10.1021/acsnano.1c10590 · Cited by 78

Fluorescence anisotropy imaging in drug discovery

Vinegoni, C., Feruglio, P. F., Gryczyński, I., Mazitschek, R., & Weissleder, R. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.01.019 · Cited by 77

Targeted Myocardial Hypoxia Imaging Using a Nitroreductase-Activatable Near-Infrared Fluorescent Nanoprobe

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Red and Near-Infrared Fluorescent Probe for Distinguishing Cysteine and Homocysteine through Single-Wavelength Excitation with Distinctly Dual Emissions

Guo, T., Chen, X., Qu, W., Yang, B., Tian, R., Geng, Z., & Wang, Z. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04895 · Cited by 75

Oxidation contributes to low glutathione in the airways of children with cystic fibrosis

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Donor–Acceptor–Donor NIR II Emissive Rhodindolizine Dye Synthesized by C–H Bond Functionalization

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SERS nanoprobes for the monitoring of endogenous nitric oxide in living cells

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A NIR fluorescent probe for the detection and visualization of hydrogen sulfide using the aldehyde group assisted thiolysis of dinitrophenyl ether strategy

Qian, M., Zhang, L., Pu, Z., Xia, J., Chen, L., Xia, Y., Cui, H., Wang, J., & Peng, X. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb02218f · Cited by 72

A protease-activated, near-infrared fluorescent probe for early endoscopic detection of premalignant gastrointestinal lesions

Yim, J. J., Harmsen, S., Flisikowski, K., Flisikowska, T., Namkoong, H., Garland, M., van den Berg, N. S., Vilches-Moure, J. G., Schnieke, A., Saur, D., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008072118 · Cited by 72

Visualizing glioma margins by real-time tracking of γ-glutamyltranspeptidase activity

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Golgi-Targeted Fluorescent Probe for Imaging NO in Alzheimer’s Disease

He, Z., Liu, D., Liu, Y., Li, X., Shi, W. S., & Ma, H. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01885 · Cited by 70

Halo-fluorescein for photodynamic bacteria inactivation in extremely acidic conditions

Wang, Y., Li, J., Zhou, Z., Zhou, R., Sun, Q., & Wu, P. (2021) · Nature Communications · doi:10.1038/s41467-020-20869-8 · Cited by 68

A Substituted‐Rhodamine‐Based Reversible Fluorescent Probe for In Vivo Quantification of Glutathione

Li, N., Wang, T., Wang, N., Fan, M., & Cui, X. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202217326 · Cited by 68

Detection of endogenous hydrogen peroxide in living cells with para-nitrophenyl oxoacetyl rhodamine as turn-on mitochondria-targeted fluorescent probe

Gu, T., Mo, S., Mu, Y., Huang, X., & Hu, L. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.127731 · Cited by 67

Intracellular chemiluminescence activates targeted photodynamic destruction of leukaemic cells

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An Edaravone-Guided Design of a Rhodamine-Based Turn-on Fluorescent Probe for Detecting Hydroxyl Radicals in Living Systems

Chen, L., Wu, X., Yu, H., Wu, L., Wang, Q., Zhang, J., Liu, X., Li, Z., & Yang, X. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03877 · Cited by 63

Nitric oxide mediates glial-induced neurodegeneration in Alexander disease

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Rational Engineering of Bioinspired Anthocyanidin Fluorophores with Excellent Two-Photon Properties for Sensing and Imaging

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A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

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A lysosome-localized thionaphthalimide as a potential heavy-atom-free photosensitizer for selective photodynamic therapy

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Accurate Fluorescence Diagnosis of Cancer Based on Sequential Detection of Hydrogen Sulfide and pH

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Simultaneous Monitoring of Mitochondrial Temperature and ATP Fluctuation Using Fluorescent Probes in Living Cells

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Novel live imaging techniques of cellular functions and in vivo tumors based on precise design of small molecule-based ‘Activatable’ fluorescence probes

Urano, Y. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.10.023 · Cited by 58

Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress

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Environmentally Robust Rhodamine Reporters for Probe-based Cellular Detection of the Cancer-linked Oxidoreductase hNQO1

Best, Q. A., Johnson, A. E., Prasai, B., Rouillere, A., & McCarley, R. L. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00792 · Cited by 57

Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous Acid

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An Activatable NIR Fluorescent Probe for NAD(P)H and Its Application to the Real‐Time Monitoring of p53 Abnormalities In Vivo

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A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression

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A singlet oxygen self-reporting photosensitizer for cancer phototherapy

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Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells

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Construction of Rhodamine‐Based AIE Photosensitizer Hydrogel with Clinical Potential for Selective Ablation of Drug‐Resistant Gram‐Positive Bacteria In Vivo

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γ-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

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Assembly of catalase-based bioconjugates for enhanced anticancer efficiency of photodynamic therapy in vitro

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A rhodamine-based fluorescent probe with high water solubility and its application in the detection of glutathione with unique specificity

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Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor‐Mediated Bioorthogonal Activation Approach

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Fluorogenic and Mitochondria-Localizable Probe Enables Selective Labeling and Imaging of Nitroreductase

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A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery

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Direct Monitoring of γ‐Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized 13C‐Labeled Molecular Probe

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A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities

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A dual-functional chemosensor for fluorescent on-off and ratiometric detection of Cu2+ and Hg2+ and its application in cell imaging

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Self-assembled, covalently linked, hollow phthalocyanine nanospheres

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Design strategies to rhodamine analogue fluorophores for near-infrared II biological imaging applications

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Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy

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Nitroso-Caged Rhodamine: A Superior Green Light-Activatable Fluorophore for Single-Molecule Localization Super-Resolution Imaging

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Emergent Fluorous Molecules and Their Uses in Molecular Imaging

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Prospects of coupled iron-based nanostructures in preclinical antibacterial therapy

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Ultrasensitive and Portable Assay for Lead(II) Ions by Electronic Balance as a Readout

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Nonpeptide-Based Small-Molecule Probe for Fluorogenic and Chromogenic Detection of Chymotrypsin

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Logic gate-based Rhodamine-methionine conjugate highly sensitive fluorescent probe for Hg 2+ ion and its application: An experimental and theoretical study

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Magnetic–Photoacoustic Dual-Mode Probe for the Visualization of H2S in Colorectal Cancer

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A New Ratiometric Design Strategy Based on Modulation of π-Conjugation Unit for Developing Fluorescent Probe and Imaging of Cellular Peroxynitrite

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Single mRNA Imaging with Fluorogenic RNA Aptamers and Small‐molecule Fluorophores

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Fabrication of a new fluorogenic probe for detection of phosgene in solution and vapor phase

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Comparative proteomics reveal distinct chaperone–client interactions in supporting bacterial acid resistance

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Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging

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Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

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Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy

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Enzyme-targeted fluorescent small-molecule probes for bacterial imaging

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Amphiphilic Rhodamine Nano-assembly as a Type I Supramolecular Photosensitizer for Photodynamic Therapy

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Strategies in the Design of Small‐Molecule Fluorescent Probes for Peptidases

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Rhodamine-triazine based probes for Cu2+ in aqueous media and living cells

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Super Light‐Sensitive Photosensitizer Nanoparticles for Improved Photodynamic Therapy against Solid Tumors

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Utilization of Nonradiative Excited-State Dissipation for Promoted Phototheranostics Based on an AIE-Active Type I ROS Generator

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Si-rhodamine fluorescent probe for monitoring of hypochlorous acid in the brains of mice afflicted with neuroinflammation

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Discovery of Nonpeptide, Reversible HER1/HER2 Dual-Targeting Small-Molecule Inhibitors as Near-Infrared Fluorescent Probes for Efficient Tumor Detection, Diagnostic Imaging, and Drug Screening

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A multifunctional near-infrared fluorescent probe for in vitro and in vivo imaging of γ-glutamyltranspeptidase and photodynamic cancer therapy

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Development of Probes with High Signal-to-Noise Ratios Based on the Facile Modification of Xanthene Dyes for Imaging Peroxynitrite during the Liver Ischemia/Reperfusion Process

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An ultrasensitive bioluminogenic probe of γ-Glutamyltranspeptidase in vivo and in human serum for tumor diagnosis

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Effects of acute oral lead exposure on the levels of essential elements of mice: a metallomics and dose-dependent study

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An SMVT-targeting and peroxynitrite-activating fluorescent probe for head and neck cancer imaging and peroxynitrite detection

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Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane–Erythrosin B Conjugate

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Immobilization of hemoglobin on chitosan films as mimetic peroxidase

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Dual hepatocyte-targeting fluorescent probe with high sensitivity to tumorous pH: Precise detection of hepatocellular carcinoma cells

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A rhodamine derivative-based fluorescent probe for visual monitoring of pH changes in the Golgi apparatus

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Synthesis of Small‐Molecule Fluorescent Probes for the In Vitro Imaging of Calcium‐Activated Potassium Channel KCa3.1

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A tunable pH probe scaffold based on sulfonamide rhodamine and its application in mitochondrial pH research

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Aluminium content of foods originating from aluminium-containing food additives

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A rhodamine-based single-molecular theranostic agent for multiple-functionality tumor therapy

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A nucleolus-targeting hill-type pH probe

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Rhodamine‐thiourea Linked Naphthalimide Derivative to Image ATP in Mitochondria using Two Channels

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Design and Synthesis of Quenched Activity‐based Probes for Diacylglycerol Lipase and α,β‐Hydrolase Domain Containing Protein 6

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Asymmetric bismuth-rhodamines as an activatable fluorogenic photosensitizer

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Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach

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Ratiometric real-time monitoring of hydroxyapatite–doxorubicin nanotheranostic agents for on-demand tumor targeted chemotherapy

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Subtle Structural Translation Magically Modulates the Super-Resolution Imaging of Self-Blinking Rhodamines

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Ultrasensitive near-infrared fluorescence probe activated by nitroreductase for in vivo hypoxia detection

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One-step activated fluorescence bioimaging of γ-glutamyltransferase activity in living cancer cells based on chloro-rhodamine probe

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Discrimination of Invasive Human Skin Tumor Using an Ultrafast ATP–Proton AND-Gate Probe

Jun, Y. W., Kim, K. H., Yang, Y. J., Jung, Y., Kim, K., Kim, H., Oh, B. H., & Ahn, K. H. (2022) · ACS Sensors · doi:10.1021/acssensors.1c02712 · Cited by 8

Synthesis of quinoline based molecular probes for detection of nitric oxide

Kaushik, D., Kaur, M., Mutreja, V., Pathania, K., Salunke, D. B., Sahoo, S. C., Saini, V., Pawar, S. V., Kansal, S. K., & Mehta, S. K. (2022) · Dyes and Pigments · doi:10.1016/j.dyepig.2022.110226 · Cited by 8

Self-Assembled Nanostructured Tin Oxide Thin Films at the Air–Water Interface for Selective H 2 S Detection

Bellare, P., Sakhuja, N., Kundu, S., Bhat, N., & Ravishankar, N. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c00412 · Cited by 6

Cellular membrane imaging of the dynamic binding-dissociation of rhodamine-benzenesulfonamide bioconjugate with carbonic anhydrase IX for inhibitor screening

Zhou, W., Qiao, Q., Tao, Y., Jiang, W., Fang, X., Li, J., Xu, N., & Xu, Z. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132980 · Cited by 6

An activatable fluorescence probe for visualization of DAGL activity in hippocampal tissue of brain-injured mice

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