Development of Polyene-Bridged Hybrid Rhodamine Fluorophores for High-Resolution NIR-II Imaging
Abstract
This work presents a polyene bridging strategy on Rhodamine-type dye analogues (Rh824, Rh926, and Rh1029) for tuning absorption and emission wavelengths from the first near-infrared window (NIR-I; 750–900 nm) to the unprecedented second near-infrared window (NIR-II; 1000–1700 nm). Phosphatidylcholine (PC) enclosures of the dyes improve water solubility and triple the fluorescent quantum yields. The representative NIR-II fluorophore Rh1029-PC presents significantly higher spatial resolution, compared to NIR-I fluorophore Rh824-PC, when performing in vivo vascular imaging. We construct a mouse vascular hemorrhage model and apply Rh1029-PC as the angiography agent in NIR-II window for the first time. The images show superior clarity of the hemorrhage positions in the NIR-II window, suggesting the successful application of the hybrid Rhodamine-derived dye in NIR-II fluorescent bioimaging.
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Rigidification of the polymethine unit by polyene bridge linkage in hybrid Rhodamine-benz[c,d]indolium dye analogues (Rh824, Rh926, Rh1029) gives absorption peaks ranging from 824 to 1029 nm and emission peaks ranging from 872 to 1093 nm.
“In another approach, the rigidification of the polymethine unit was achieved by the polyene bridge linkage in hybrid Rhodamine-benz[c,d]indolium dye analogues (Rh824, Rh926, and Rh1029) with absorption peaks ranging from 824 to 1029 nm and emission peaks ranging from 872 to 1093 nm.45”
Cites
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386 · see citing works
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NIR-II bioimaging of small organic molecule
Su, Y., Yu, B., Wang, S., Cong, H., & Shen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120717 · Cited by 251 · see citing works
Establishing design principles for emissive organic SWIR chromophores from energy gap laws
Friedman, H. C., Cosco, E. D., Atallah, T. L., Jia, S., Sletten, E. M., & Caram, J. R. (2021) · Chem · doi:10.1016/j.chempr.2021.09.001 · Cited by 145 · see citing works
Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works
Photophysical Properties of Indocyanine Green in the Shortwave Infrared Region
Cosco, E. D., Lim, I., & Sletten, E. M. (2021) · ChemPhotoChem · doi:10.1002/cptc.202100045 · Cited by 79 · see citing works
NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications
Li, C., Guan, X., Zhang, X., Zhou, D., Son, S., Xu, Y., Deng, M., Guo, Z., Sun, Y., & Kim, J. S. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114620 · Cited by 49 · see citing works
Piwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging
Lin, J., Li, Q., Zeng, X., Chen, Z., Ding, Q., Li, Y., Zhou, H., Meng, X., Chen, D., Deng, Z., et al. (2020) · Science China Chemistry · doi:10.1007/s11426-019-9685-6 · Cited by 29 · see citing works
Gao, X., Wang, J.-Y., Qin, Y., Zhu, Y., Liu, Y.-J., Zhou, K., & Cui, M. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05794 · Cited by 20 · see citing works
Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque
Xu, X., Ma, Y., Cao, H., Xu, L., Chen, H., Liu, S., Sun, W., Song, G., & Zhang, X.-B. (2025) · Science China Chemistry · doi:10.1007/s11426-024-2361-x · Cited by 21 · see citing works
- Authors
- Shi, Y., Yuan, W., Liu, Q., Kong, M., Li, Z., Feng, W., Hu, K., & Li, F.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Hu, Ke
- Li, Fuyou
- Venue
- ACS Materials Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-08-29
- Volume
- 1
- Issue
- 4
- Pages
- 418-424
- ISSN
- 2639-4979 (ISSN-L)
- OpenAlex
- W2970334092
- Cited by
- 80
- References
- 2
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 13 · 2023: 12 · 2022: 12 · 2021: 12 · 2020: 9
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Materials Letters (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2017YFA0205100, 2016YFC1303100)
- China Postdoctoral Science Foundation (2018M632006)
- Ministry of Human Resources and Social Security (BX20190073)
- National Natural Science Foundation of China (21872037)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- rhodamine dyes, NIR-II imaging, near-infrared fluorescent dyes, aqueous solubility enhancement, quantum yield, vascular imaging, angiography, in vivo imaging, spatial resolution
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